Arginine Pyroglutamate

What's this

Arginine Pyroglutamate is the Pyroglutamate salt of the amino acid Arginine.
This salification would improve the central tropism of Arginine and of the same Pyroglutamate, being useful in safeguarding some important brain functions.

Indications

Why is Arginine Pyroglutamate used? What is it used for?

Arginine Pyroglutamate - Chemical Structure

Thanks to the better ability of Arginine Pyroglutamate, compared to Arginine itself, to cross the blood-brain barrier and reach the central nervous system, Arginine Pyroglutamate supplements are used above all to improve cognitive performance.
Mainly for this reason, Arginine Pyroglutamate is distinguished from the other salts of Arginine, formulated instead to improve the general bioavailability of the amino acid.

Properties and Effectiveness

What benefit has Arginine Pyroglutamate shown during the studies?

According to some experts, the supposed central activity of Arginine Pyroglutamate derives from the chemical similarity with the piracetam molecule, an active principle known for its high neurological tropism.
According to some studies, mostly experimental, the use of Arginine Pyroglutamate would protect the central nervous system (especially some higher functions such as memory and reasoning skills), from the decline linked to aging or damage induced by alcohol.
Despite some very encouraging work, there is still a lack of particularly relevant evidence.

Dosage and method of use

How to use Arginine Pyroglutamate

The recommended daily dosages of Arginine Pyroglutamate are generally between 500 and 1,000 mg.
The salification of Arginine with Pyroglutamate should both improve the intestinal absorption of the active principle and increase its nervous tropism, allowing the Pyroglutamate to cross the blood brain barrier.

Side effects

The use of Arginine Pyroglutamate, at the above dosages, is generally well tolerated and free from clinically relevant side effects.

Contraindications

When should Arginine Pyroglumate not be used?

The use of Arginine Pyroglutamate is contraindicated in case of ascertained hypersensitivity to the active ingredient, during pregnancy and breastfeeding and in children.

Pharmacological interactions

What drugs or foods can modify the effect of Arginine Pyroglutamate?

As for L-Arginine, the contextual use of Cyclosporine, Ibuprofen, organic Nitrates, Sildenafil and plant extracts such as Yohimbe, could contribute to the onset of pharmacokinetic and pharmacodynamic variations in the activity of Arginine Pyroglutamate.