in the blood for the past three months. Therefore, the glycated hemoglobin allows to know if the glycaemia has exceeded the "guard" levels in people with diabetes or at risk of becoming one.
Glycated hemoglobin is formed when too much glucose accumulates in the blood: through a process called glycosylation, a sugar molecule binds to the hemoglobin contained in red blood cells (which have an average life of about 120 days), in proportion to the glycemia.
HbA1c is less effective than normal hemoglobin in oxygen transport. Furthermore, glycation of hemoglobin is a major cause of organ damage during diabetic disease.
The blood glucose test is not routinely ordered, but only in people with suspected diabetes or those with a confirmed diagnosis who are undergoing treatment for hyperglycemia.
However, the most typical application of glycated hemoglobin remains the evaluation of glyco-metabolic control in the medium and long term; several studies have in fact shown a close correlation between the degree of glycemic control, assessed on the basis of HbA1c levels, and the risk of development and progression of chronic complications of diabetes.
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Glycated hemoglobin is formed when too much glucose accumulates in the blood: through a process called glycosylation, a sugar molecule binds to the hemoglobin contained in red blood cells (which have an average life of about 120 days), in proportion to the glycemia.
HbA1c is less effective than normal hemoglobin in oxygen transport. Furthermore, glycation of hemoglobin is a major cause of organ damage during diabetic disease.
The blood glucose test is not routinely ordered, but only in people with suspected diabetes or those with a confirmed diagnosis who are undergoing treatment for hyperglycemia.
Hemoglobin (Hb)
Hemoglobin (Hb) is the protein contained in red blood cells that carries oxygen to the tissues and is responsible for their red color (due to the iron contained in the molecule).
However, the most typical application of glycated hemoglobin remains the evaluation of glyco-metabolic control in the medium and long term; several studies have in fact shown a close correlation between the degree of glycemic control, assessed on the basis of HbA1c levels, and the risk of development and progression of chronic complications of diabetes.
Glycated hemoglobin is used both as an average glycemic index and as an assessment of the risk of developing diabetes complications. It can also be used for diagnostic purposes according to criteria being defined.
In the diabetic, the efficacy of a drug or therapeutic action is assessed through its influence on glycated hemoglobin levels.
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