KESTINE ® is an Ebastine-based drug
THERAPEUTIC GROUP: Antihistamines for systemic use - H1 antagonist
Indications KESTINE ® - Ebastine
KESTINE ® is indicated in the symptomatic treatment of allergic diseases such as allergic rhinitis, allergic conjunctivitis and chronic idiopathic urticaria.
Mechanism of action KESTINE ® - Ebastine
The antihistamine activity of KESTINE ® is guaranteed by the presence of its active ingredient Ebastine, counted among the second generation H1 receptor antagonists, characterized by reduced effects on the central nervous system, therefore by a higher tolerability than its predecessors. first generation.
This difference is due to the inability of Ebastine to cross the blood brain barrier, producing its effects at the nervous level, and to bind only histamine H1 receptors with high affinity, while also reducing the anticholinergic potential, often associated with major cardiovascular disorders.
This mechanism allows Ebastine to exert an important action at the respiratory and skin level, reducing the vascular permeability of the perivenular capillaries with the consequent edema action, and controlling any bronchospasms induced by the activation of histamine receptors present on smooth muscles bronchial.
This is also facilitated by the advantageous pharmacokinetic properties, which allow the active principle taken orally to rapidly reach pharmacologically active concentrations, and to maintain the antihistamine activity for several hours after the suspension of therapy.
Ebastine, after an intense first pass metabolism, and after having completed its therapeutic action is eliminated mainly by the kidney.
Studies carried out and clinical efficacy
EBASTINA AND VENTILATORY CAPACITY
Allergy Asthma Proc. 2007 Sep-Oct; 28: 578-81.
Ebastine improves nasal symptoms and airflow and affects response to decongestion test in patients with persistent allergic rhinitis: a pilot study.
Ciprandi G, Cirillo I, Mora F, La Rosa M.
Study that demonstrates how Ebastine treatment can significantly improve nasal respiratory flow ensuring a significant decongestant action in patients suffering from persistent allergic rhinitis.
EBASTINE IN SOLUBLE TABLETS AND THERAPEUTIC EFFECTIVENESS
Clin Ther. 2007 May; 29: 814-22.
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adults .
Antonijoan R, García-Gea C, Puntes M, Pérez J, Esbrà R, Serra C, Fortea J, Barbanoj MJ.
Work conducted on healthy non-atopic individuals with the aim of characterizing the antihistamine efficacy of active ingredients such as Ebastine, which demonstrates how the use of 20 mg per day of this drug in soluble tablets can guarantee excellent therapeutic results.
EBASTIN AND ANTI T-CELL ACTION
Clin Exp Allergy. 2003 Nov; 33: 1544-54.
Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines.
Nori M, Iwata S, Munakata Y, Kobayashi H, Kobayashi S, Umezawa Y, Hosono O, Kawasaki H, Dang NH, Tanaka H, Shiohara T, Morimoto C.
Interesting cellular study, which demonstrates how Ebastine can have an inhibitory role against the production of cytokines from Th2, thus being able to play an important role in the control of T-cell mediated pathologies such as allergic inflammatory disorders, atopic dermatitis, l "€ ™ asthma and other autoimmune diseases.
Method of use and dosage
KESTINE ®
Ebastine 10 - 20 mg coated tablets.
The therapy with KESTINE ® should be defined, both in the dosages and in the modalities of assumption, by the doctor on the basis of the physiopathological characteristics of the patient and the severity of his clinical picture.
However, the daily dose of 10 mg of Ebastine is generally sufficient in guaranteeing a remission of symptoms both in the course of chronic idiopathic urticaria and in the course of allergic rhinitis, although double doses have been used successfully in the treatment of the most severe rhinitis.
On the other hand, a dosage adjustment would be required in patients with severe liver and kidney disease.
KESTINE ® warnings - Ebastine
Although the use of antihistamines is widespread among citizens, it would be advisable, before taking KESTINE ®, to consult your doctor, evaluating the possible presence of contraindications to the use of medication rather than prescriptive appropriateness.
The administration of KESTINE ® should take place with particular care in patients suffering from hepatic and renal pathologies, in which the metabolic characteristics of Ebastine could be seriously compromised, and in patients with cardiovascular pathologies.
KESTINE ® contains lactose, therefore its use would not be indicated in patients with lactase enzyme deficiency, glucose-galactose malabsorption syndrome and rare hereditary problems of galactose intolerance.
In order to obtain adequate results, it is recommended to stop taking antihistamines at least 48 hours before allergy tests.
Keep this medicine out of the reach of children.
PREGNANCY AND BREASTFEEDING
Given the absence of studies able to ascertain the safety profile of Ebastine for fetal health and the ability of the active ingredient to cross the placental barrier and the mammary filter, it is necessary to extend the aforementioned contraindications to the " € ™ use of KESTINE ® also during pregnancy and the subsequent period of breastfeeding.
Interactions
In order to preserve the safety and efficacy of therapy with KESTINE ®, it would be advisable to avoid the simultaneous intake of active ingredients with cardiotoxic potential or with marked hepatic tropism.
In any case it is necessary to consult your doctor if the simultaneous administration of other active ingredients becomes necessary.
Contraindications KESTINE ® - Ebastine
The use of KESTINE ® is contraindicated in case of hypersensitivity to the active substance or to one of its excipients or to other structurally related molecules, in patients with severe liver disease and in children under 12 years of age.
Undesirable Effects - Side Effects
The use of Ebastine, especially when prolonged over time, could lead to the onset of dyspepsia, abdominal pain, nausea, vomiting, asthenia, edema, impaired liver function, insomnia, nervousness, mental disorders, tachycardia and only rarely dermatological reactions from hypersensitivity to the active ingredient.
Note
KESTINE ® is a prescription drug.
The information on KESTINE ® - Ebastina published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.
