Amfepramone: What is it? How does it work? Warnings and Contraindications

; it is an amphetamine-like molecule, therefore with a stimulating action.

Note: Amfepramone-containing drugs are currently withdrawn from the market.

Examples of Specialty Medicines Containing Amfepramone

• Line ® - Revoked
• Regenon ® - Revoked
• Tepanil ® - Revoked.

both schizophrenic and depressive; after the introduction of psychoeleptic drugs and antidepressants, the use of amphetamines in antipsychotic therapy is no longer justified, it is useless and can be harmful.

In general, the effects of amfepramone can be summarized as follows:

• Stimulation of psychomotor activity
• Disappearance of tiredness, fatigue and asthenia
• Stimulation of alertness with relative difficulty falling asleep or insomnia
• Reduction of appetite with decrease in food consumption and regression of obesity
• Peripheral sympathetic stimulation with vasoconstriction, tachycardia, tendency to hypertension and coronary spasms.

Does amfepramone make you lose weight?

The most recent cases of therapeutic use of amfepramone were for anorectic purposes (suppression of appetite), by virtue of its important central stimulation function. However, starting from August 2011 this molecule was classified as narcotic due to the manifestation of suspicious deaths, probably related to the use of amfepramone.

DECREE 2 August 2011

Updating and completion of the tables containing the indication of narcotic and psychotropic substances, referred to in the decree of the President of the Republic October 9, 1990, n. 309 and subsequent amendments and additions. Relocation to table I of the substances Amfepramone (diethylpropion), Fendimetrazine, Phentermine and Mazindolo. (11A10727) (GU General Series No. 180 of 4 August 2011)

1. In table I referred to in article 14 of the decree of the President of the Republic of 9 October 1990, no. 309, the following substances are added, according to the alphabetical order:
   1. Amfepramone, common name 2- (diethylamino) propiophenone, chemical name Diethylpropion, other name
   2. Phendimetrazine, common name (+) - (2S, 3S) -3,4-dimethyl-2-phenylmorpholine, chemical name Phentermine, common name Alfa, alpha-dimethylphenylethylamine, chemical name Mazindole, common name 5- (para-chlorophenyl) - 2,5-dihydro-3H-imidazo [2,1-a] isoindol-5-ol, chemical name.

there may be an increase in intoxication, therefore an increase in danger. Amfepramone, like other amphetamine-like, can induce an erroneous feeling of security in one's mental faculties, inducing the subject to perform acts not permitted by the state of drunkenness Finally, it should be remembered that amphetamines can cause drug addiction in themselves.

to the use of amphetamine-like - minor for amfepramone compared to other molecules:

• Arterial hypertension, heart disease and coronary heart disease
• All states of hypersympatheticotonia
• Anxious and manic states, psychosis, prepsychotic states.

and serotonergic, but it has a 10 to 20 times higher efficacy in noradrenenrgic mechanisms.

Please note

Amfepramone-based medicines have been revoked and are no longer marketed in Italy; therefore, they can neither be used nor prescribed.

Riccardo Borgacci

Graduated in Exercise Science and Dietetics, he practices as a freelance outpatient activity as a dietician and personal trainer