= number of platelets per volume of blood), MPV can give an "idea of the degree of efficiency of the blood clotting mechanisms; these, in fact, depend on many factors and in any case not only on the number of platelets, but also on the relative volume and by its uniformity (PDW).
Platelets survive in the bloodstream for about 8-10 days and the bone marrow must continually produce new elements to replace those degraded, consumed and / or lost during bleeding.
Mean platelet volume (MPV) is a parameter that indicates the average size of these cells and is typically included in blood tests as part of the blood count.
Several factors can change the normal size of platelets:Heart attack; Arteriopathies; Mediterranean macrothrombocytosis; Removal of the spleen Diabetes; Bernard-Soulier syndrome; Transient medullary hypoplasia; Preeclampsia; Inflammatory bowel diseases. ; Medullary platelet-induced depression (B12 and folate deficiency, chemotherapy, neoplastic infiltration, hypersplenism).
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Platelets survive in the bloodstream for about 8-10 days and the bone marrow must continually produce new elements to replace those degraded, consumed and / or lost during bleeding.
Mean platelet volume (MPV) is a parameter that indicates the average size of these cells and is typically included in blood tests as part of the blood count.
Several factors can change the normal size of platelets:
- In the event that the bone marrow is subject to dysfunction, the volume of platelets produced could be reduced;
- In the event that the amount of synthesized platelets is, however, insufficient, the bone marrow can try to make up for this deficiency by producing larger platelets.
It must also be taken into account that the newly produced platelets are of greater volume, while those that have been in circulation for a few days tend to become smaller in size. In other words, young platelets are characterized by an increased mean volume (> MPV) compared to older ones.
).The parameter can also be related to one or more platelet function tests and / or other analyzes for the evaluation of coagulation, such as PT (Prothrombin Time) and PTT (Partial Thromboplastin Time).
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