Creatinine and Creatininemia
Since the one described above is a rather laborious procedure, in many cases it is preferred to use an indirect method, which allows to estimate the extent of glomerular filtration based on some simple parameters: age, sex, weight and creatinine. they will then be inserted in the Cockcroft and Gault formula:
CLEARANCE CREATININE MALE: (140- age) / (72 x Scr) x Weight
CLEARANCE CREATININE FEMALES: males x 0.85
Where: Scr = blood creatinine (mg / 100 mL)
Or in that of MDRD, which gives an estimate of glomerular filtration taking into account age and sex
Renal glomerular filtrate =
186.3 x (Scr -1.154 x age -0.203) x (0.742 if woman)
Analyzing this formula it is clear that creatinine clearance is lower the higher its concentration in the blood; in other words, "eleavata creatininemia indicates a reduced elimination of the metabolite by the kidney.
Creatinine clearance is lower in females, due to the small size of the kidneys, and in the elderly, in relation to glomerulosclerosis associated with aging.
It must also be considered that high levels of creatinine in the blood can be observed in patients who follow a diet excessively rich in meat foods, in athletes who take creatine supplements and especially in those with massive muscle mass. Similarly, very low values are found in the presence of muscle atrophy (senescence, malnutrition) and in pregnancy; for this reason the serum creatinine dosage in an elderly or pregnant patient can easily underestimate the degree of renal insufficiency. Bordering the pathological, elevated levels of creatininemia are found in the presence of polyarthritis, cardiocirculatory decompensation, muscle trauma, hyperthyroidism and acromegaly.
In these cases it is much more reliable to detect creatinine clearance by the classical method.
Normal reference values for creatinine and creatinine clearance
Creatininemia µmol / L
Creatininemia (mg / dL)
Creatinine clearance (mL / min)
<12 years
22 - 75
0,25 - 0,85
50 - 90
Adult males
57 - 92
0,64 - 1,04
97 - 137
Adult females
50 - 81
0,57 - 0,92
88 - 128
Select Blood Tests Blood Tests Uric acid - uricaemia ACTH: adrenocortitotropic hormone Alanine amino transferase, ALT, SGPT Albumin Alcoholism Alphafetoprotein Alphafetoprotein in pregnancy Aldolase Amylase Ammonemia, ammonia in the blood Androstenedione Antibody-endomysial antibodies Anti-gliadicides Nucleus Helicobacter pylori antibodies Embryo carcinoal antigen - CEA Prostate specific antigen PSA Antithrombin III Haptoglobin AST - GOT or aspartate aminotransferase Azotemia Bilirubin (physiology) Direct, indirect and total bilirubin CA 125: tumor antigen 125 CA 15-3: tumor antigen 19-9 as tumor marker Calcemia Ceruloplasmin Cystatin C CK-MB - Creatine kinase MB Cholesterolemia Cholinesterase (pseudcholinesterase) Plasma concentration Creatine kinase Creatinine Creatinine Creatinine clearance Chromogranin A D-dimer Hematocrit Blood culture Hemocrome Hemoglobin Glycated hemoglobin a Blood tests Blood tests, Down syndrome screening Ferritin Rheumatoid factor Fibrin and its degradation products Fibrinogen Leukocyte formula Alkaline phosphatase (ALP) Fructosamine and glycated hemoglobin GGT - Gamma-gt Gastrinemia GCT Glycemia Red blood cells Granulocytes HE4 and Cancer at "Ova" Immunoglobulins INR Insulinemia Lactate dehydrogenase LDH Leukocytes - white blood cells Lymphocytes Lipases Tissue damage markers MCH MCHC MCV Metanephrines MPO - Myeloperoxidase Myoglobin Monocytes MPV - average platelet volume Natremia Neutrophils Homocysteine Thyroid hormones OGTT Osmocyte Plasma protein A associated with pregnancy Peptide C Pepsin and pepsinogen PCT - platelet or platelet hematocrit PDW - distribution width of platelet volumes Platelets Plateletpenia PLT - number of platelets in blood Preparation for blood tests Prist Test Total IgEk Protein C (PC) - Protein C Activated (PCA) C Reactive Protein Rast Protein Test Specific IgE Reticulocytes Renin Reuma-Test Oxygen Saturation Sideremia BAC, BAC TBG - Thyroxine Binding Globulin Prothrombin Time Partial Thromblopastin Time (PTT) Activated Partial Thromboplastin Time (aPTT) Testosterone Testosterone: free and bioavailable fraction Thyroglobulin Thyroxine in the blood - Total T4, free T4 Transaminases High transaminases Transglutaminase Transferrin - TIBC - TIBC - UIBC - saturation of transferrin Transtyretin Triglyceridemia Triiodothyronine in the blood - Total T3, free T3 Troponin TRH and Troponins of s thymol to TRH TSH - Thyrotropin Uremia Liver values ESR VDRL and TPHA: serological tests for syphlis Volemia Conversion of bilirubin from mg / dL to µmol / L Conversion of cholesterol and triglyceridemia from mg / dL to mmol / L Conversion of creatinine from mg / dL to µmol / L Conversion of blood glucose from mg / dL to mmol / L Conversion of testosteronemia from ng / dL - nmol / L Conversion of uricemia from mg / dL to mmol / L
