Generality
Aldolase is an enzyme normally present in many tissues and organs (skeletal muscle, myocardium, liver and brain). In these areas, it participates in the production of energy from glucose.
The circulating amount of aldolase can be detected with a blood test. An increase in the enzyme values is indicative of some diseases related to skeletal muscle, including Duchenne muscular dystrophy and polymyositis. Aldolase can also increase during myocardial infarction and during some chronic liver diseases.
What's this
Aldolase is a ubiquitous enzyme (ie it is found everywhere in the body). However, it is found in high concentrations especially in muscle tissue, in the form of three different isoforms (aldolase A, B and C).
Aldolase is involved in glycolysis, ie in the utilization of glucose as an energy substrate.
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