, perturbing the mechanisms that regulate its synthesis and differentiation.
The bone marrow is the main hematopoietic organ, therefore responsible for the formation of red blood cells (erythropoiesis), granulocytes (granulopoiesis, forms polymorphonuclear leukocytes - neutrophils, eosinophils and basophils), monocytes (monocytopoiesis, from which tissue macrophages also arise), lymphocytes (lymphocytopoiesis) and platelets (megakaryocytopoiesis).
The bone marrow, as actively proliferating, is very susceptible to DNA damage caused by radiation, cytostatic therapies or environmental toxic factors.
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Due to this mutation, immature neoplastic clones are formed which reproduce rapidly and invasively, replacing normal hematopoietic cells in the bone marrow.
To understand this brief introduction it is necessary to know the basic concepts of hematopoiesis (process that leads to the formation and maturation of blood cells starting from their precursors); let's see them in detail before moving on to the analysis of the causes and symptoms of leukemia .
, in the ribs, in the pelvis, in the skull and in the epiphyses of the long bones).The bone marrow is the main hematopoietic organ, therefore responsible for the formation of red blood cells (erythropoiesis), granulocytes (granulopoiesis, forms polymorphonuclear leukocytes - neutrophils, eosinophils and basophils), monocytes (monocytopoiesis, from which tissue macrophages also arise), lymphocytes (lymphocytopoiesis) and platelets (megakaryocytopoiesis).
The bone marrow, as actively proliferating, is very susceptible to DNA damage caused by radiation, cytostatic therapies or environmental toxic factors.
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