It is an active ingredient particularly useful for the treatment of mycoses of the skin and mucous membranes (including genital ones).
Nystatin is available in medicines for oral use in the form of an oral suspension. In combination with nifuratel - a synthetic antibacterial chemotherapy - on the other hand, nystatin is available in medicines suitable for the treatment of vulvovaginal diseases. More precisely, these medicines are formulated as vaginal capsules, vaginal pessaries or vaginal creams.
Medicines containing only nystatin for oral use are classified as class A drugs, therefore, their cost can be reimbursed by the National Health System (NHS). Medicines containing nystatin in combination with nifuratel for vaginal use, on the other hand, are classified as class C drugs - therefore, their cost is fully borne by the citizen - and can only be dispensed upon presentation of a repeatable medical prescription. (RR).
Examples of Medicines containing Nystatin
- Mycostatin®
- Inimur Complex® (in association with nifuratel)
- Macmiror Complex® (in association with nifuratel)
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Nystatin is also used in the veterinary field. It can be found in specific medicines - in the form of ear drops and in combination with other active ingredients - for the treatment of external ear infections caused by infections caused by fungi and bacteria sensitive to the active ingredients contained in the medicine.
it's indicated:
- In the prevention and treatment of mouth infections caused by such fungi Candida in both pediatric (from one month of life to 18 years of age) and adult patients;
- In the prevention of oral infections caused by Candida albicans(thrush or oral candidiasis) in infants up to one month old, especially in those whose mothers had positive cultures of the vaginal discharge.
Nystatin in association with local nifuratel, on the other hand, is used in:
- Multipurpose treatment of vulvovaginal diseases caused by pathogenic microorganisms such as fungi belonging to the genus Candida, Trichomonas vaginalis (a protozoan) and bacteria.
If any type of allergic reaction occurs during therapy with nystatin by any route of administration, treatment with the drug should be stopped immediately and the physician immediately alerted.
Good oral hygiene should be maintained before starting oral nystatin treatment for its entire duration.
As regards the use of nystatin in association with nifuratel at the vaginal level, however, we remind you that the use of eggs, soft capsules and vaginal creams - especially if prolonged - can cause sensitization phenomena. Also, while using these medicines, it is necessary to refrain from sexual intercourse.
(OTC), herbal and phytotherapeutic products, homeopathic products, etc. which can manifest themselves with:- Skin rashes;
- Urticaria;
- Angioedema;
- Stevens-Johnson Syndrome.
Unwanted Effects of Nystatin and Nifuratel by the vaginal route
- Sensitization phenomena, especially following prolonged use;
- Allergic reactions that can occur with skin rashes;
- Dermatitis;
- Urticaria;
- Vaginal burning
- Vaginal itching.
PLEASE NOTE
For more detailed information on the specific side effects of nystatin medicines, please refer to the package leaflet of the medicine you are taking.
Oral nystatin overdose
Nausea and disorders of the gastrointestinal system may occur if an excessive dose of nystatin is taken by mouth.
If you suspect or are sure of a nystatin overdose, you should contact your doctor right away or go to the nearest hospital.
mushrooms. This active principle, in fact, has a great affinity for membranes containing ergosterol, such as those of fungi. More specifically, nystatin is capable of inserting itself inside the cell membrane and increasing its permeability. Due to this increase in permeability, the fungal cells lose their essential constituents (such as ions and small organic molecules) and, consequently, , they die.Nifuratel, on the other hand, is an active ingredient with antibacterial action against different types of microorganisms, with antiprotozoal action (also useful against Trichomonas vaginalis) and antifungal action.
. In any case, some information will be provided below.
Oral nystatin
Prevention and treatment of mouth infections caused by Candida in adults, adolescents and children 2 to 18 years of age
The dose usually used is 400,000-600,000 I.U. four times a day. If your doctor deems it necessary, he can increase the dose administered.
Prevention and treatment of mouth infections caused by Candida in infants from one month to two years of age
The dose usually used is 200,000 I.U. four times a day. If necessary, your doctor can increase this dose.
Prevention and treatment of mouth infections caused by Candida (thrush) in infants up to one month of age
The dose usually used is 100,000 I.U. once a day, instill directly into the mouth with the dropper.
Note: shake the oral suspension well before use. The medicine should be administered by placing half the dose in each side of the mouth and holding it for as long as possible before swallowing. For more information on correct method of use and time of use , consult your doctor and read the package leaflet of the medicine carefully.
Nystatin and Nifuratel in vaginal cream
The dose usually used is 2.5 g of cream - once or twice a day - to be introduced into the vagina in the evening and / or in the morning. The cream must be applied using the appropriate dosing syringe.
Nystatin and Nifuratel vaginal suppositories
The dose usually used is one egg per day, or according to medical prescription, to be inserted deeply into the vagina.
Nystatin and Nifuratel soft vaginal capsules
Generally, the recommended dose is one softgel per day, or according to medical prescription, to be inserted deeply into the vagina.
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In any case, both pregnant women and mothers who are breastfeeding should definitely seek advice from their doctor or gynecologist before taking nystatin.
