Mega Ram Plus - Eurosup

About Mega Ram Plus - Eurosup

Mega Ram Plus - Eurosup

Food supplement of branched chain amino acids, with Vitamin B6

FORMAT
Pack of 90/180/300 tablets

INGREDIENTS: L-Leucine - L-Isoleucine - L-Valine - Emulsifier: Microcrystalline Cellulose - Anti-caking agents: silica, Magnesium stearate - Vitamin B6.

For 5 tablets: - L-leucine 2500 mg - L-valine 1250 mg - L-isoleucine 1250 mg - Vitamin B6 0.6 mg

Note: the amino acids present in this supplement are synthesized using the Kyowa protocol, which guarantees high levels of purity and quality of the product.

Branched chain amino acids - Leucine, Isoleucine and Valine: also known as branched-chain amino acids, they are among the essential amino acids and as such must necessarily be introduced through the diet. A healthy diet is able to provide the correct amount of these amino acids with various foods, both of animal and vegetable origin. Like the other amino acids, they are absorbed by the brush border in the apical portion of the enterocyte, through transport mechanisms facilitated by sodium, and introduced into the bloodstream from the basal lateral domain. Unlike the other amino acids, however, they manage to bypass the hepatic metabolism, probably due to the absence of specific enzymes, and reach the muscle tissue where they represent about 1/3 of the total amino acid pull; and it is precisely at the muscle level that the branched amino acids carry out their biological functions:

1. By replenishing the Krebs cycle with oxaloacetate and pyruvate, during prolonged fasting or intense physical activity;
2. Re-entering the synthesis of glucose starting from non-glucidic metabolites;
3. By increasing the levels of alanine and facilitating its transport to the liver;
4. Representing an important substrate for protein synthesis;
5. Restoring the contractile functions of myofibrils;
6. Protecting the muscle from excessive catabolism.

The wide use, and many times the abuse, in sports practice, is due not only to these properties universally recognized by the scientific world, but also to other particular abilities, much debated but which would represent the most precious benefits for the athlete:

1. REDUCTION OF THE FEELING OF FATIGUE;
2. PROMOTION OF ANABOLIC PROCESSES.

BCAA and reduction of the feeling of fatigue

One of the metabolic pathways involved in the onset of the sensation of fatigue is that associated with the production of a neurotransmitter with sedative capacity, which is serotonin. The main precursor of this molecule is an aromatic amino acid, tryptophan, which through specific transporters is in able to cross the blood-brain barrier, facilitating the synthesis of serotonin. The mechanisms that determine the increase in plasma levels of free tryptophan, in addition to dietary intake, are mainly two:

1. Increased proteolysis;
2. Detachment from albumin.

During normal physical activity, and in particular the more lasting one, there is an increase in lipolysis, with the consequent increase in free fatty acids, which can compete with tryptophan for binding to "albumin. This competitive action, together" to proteolysis induced by intense physical exercise, it shifts the balance towards the free form of tryptophan, which can therefore effectively cross the blood-brain barrier and represent a fundamental substrate for the synthesis of serotonin and the consequent onset of fatigue.BCAAs can reduce this effect, on the one hand by preserving the muscle from damage induced by strenuous exercise, and on the other by competing with tryptophan for the blood brain barrier transporter.

BCAAs and promotion of anabolic processes

Starting from the assumption that the various experts seem to agree in considering the BCAAs useful in preserving muscle integrity and in reducing the proteolysis induced by intense physical exercise, preliminary studies conducted in vitro have shown how these can also increase the levels of protein synthesis. Of course, this action is independent of the simple action of substrate against protein synthesis, but calls for more important capabilities, such as hormonal modulation and the regulation of intracellular signaling.
Regarding hormonal modulation, there are several studies in the literature, many of which disagree, which highlight how BCAAs can increase the levels of GH, testosterone and reduce those of cortisol. However, the lack of understanding of a molecular mechanism, and the low reproducibility of the data, make this hypothesis unreliable.

More characterized, although not entirely, is the action on insulin control and on the relative signal transmission. Studies show that BCAAs, thanks to the gluconeogenic role and the ability to increase glucose-alanine flow, can control the profile glycemic and induce insulin secretion, very important in post work-out to facilitate muscle recovery. At the same time, these amino acids, and in particular Leucine, seem to be able to directly, or through metabolites such as hydroxymethylbutyrate, control some signaling pathways intracellular, and thus increase the levels of protein synthesis.

Vitamin B6 - also known as pyridoxine, is transformed and phosphorylated in the liver into pyridoxal phosphate, an important coenzyme involved in numerous key reactions of amino acid metabolism (oxidative transamination and deamination), lipid (synthesis of sphingolipids) and glucose. It is therefore easy to understand the usefulness of this vitamin in supporting the correct oxidation and transamination of branched-chain amino acids, improving their metabolic-nutritional action.
The daily requirement of vitamin B6 is around 1 / 1.5 mg, but even in this case the episodes of deficiency are very rare.

Rationale for use - Mega Ram Plus - Eurosup

Although the experimentation of BCAAs in sports has been underway for years, a conclusion has not yet been reached on the beneficial effects related to their use. In fact, only the metabolic and my protective role of branched-chain amino acids seems to be demonstrated, while the anti-fatigue effect is still to be investigated. Further studies, moreover, will be indispensable to clarify the potential modulator role both on hormonal secretion and on intracellular signaling. given the numerous applications that these can derive not only in the sports world.

Method of use recommended by the company - Mega Ram Plus - Eurosup

5 tablets once a day with water or juice, 20-30 minutes before training.

Method of use in sports - Mega Ram Plus - Eurosup

When it comes to amino acid or protein supplements, it is very important to consider that an effective supplementary protocol inevitably involves the observation of the athlete's physio-pathological, athletic, nutritional and dietary aspects. Despite the presence of repeated and recommended dosages, it therefore becomes difficult to define an effective and valid dose for everyone. The various studies, among other things, use very different dosages, also depending on the objectives to be achieved and the hypotheses to demonstrate: in this regard, they range from 0.2 gr / kg / day for a month to increase the basal levels of GH to 12 gr / day to reduce plasma levels of creatinkinase and lactic dehydrogenase following intense exercise. Various dosages are also recommended in sports: from 83mg / kg / day for amateur sportsmen to 250mg / kg / day for sports competitive cyclist.
Despite the enormous variability, some constants must always be taken into account:

1. Keep the Ile / Leu / Val ratio at 2: 1: 1 as much as possible
2. Prefer to take on an empty stomach
3. Prefer to take about 60 "before training, or in the immediate post work out.

The product in question allows to satisfy the average BCAA requirement of a 70kg man, with only 5 tablets per day, which could be taken before training or distributed between pre and post work-out.

Sinergie Mega Ram Plus - Eurosup

BCAA + Arginine: a study carried out on 8 healthy volunteers shows a significant reduction in phenylalanine levels (marker of muscle proteolysis) following physical exercise preceded by integration with 2 g of BCAA and 0.5 g of arginine.
BCAA + Carbohydrates: some studies show a useful synergy to reduce the feeling of fatigue during athletic performance (potential role of BCAAs), and improve performance (energy role of carbohydrates). In the post work out, however, BCAAs seem to improve insulin sensitivity, therefore the resynthesis of glycogen in the presence of CHO, while high glycemic index carbohydrates, by increasing insulin secretion, can both favor the absorption of the same BCAAs and support the anabolic phase

Mega Ram Plus side effects - Eurosup

Known are the long-term side effects of a diet too rich in protein or amino acids. Damage to the kidney, dehydration induced by increased urinary secretion, lipidemic alterations and associated pathologies, tissue acidosis and bone demineralization, are just some of the consequences of a prolonged unbalanced diet.
Acute BCAA ingestion appears to be well tolerated and free from side effects, even when concentrations rise to 450mg per pound of body mass.

Precautions for using Mega Ram Plus - Eurosup

The product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, in pregnancy, during lactation, under 12 years and in adolescents not yet trained.
In case of prolonged use (over 6/8 weeks) the doctor's opinion is necessary.

This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of Mega Ram Plus - Eurosup.

BIBLIOGRAPHY

J Strength Cond Res. 2010 Apr 7. [Epub ahead of print]
BCAA Supplementation Lowers Perceived Exertion But Does Not Affect Performance in Untrained Males.
Greer BK, White JP, Arguello EM, Haymes EM.
J Strength Cond Res. 2010 Apr; 24: 1125-30.

Amino acid supplements and recovery from high-intensity resistance training.

Sharp CP, Pearson DR.
J Sports Med Phys Fitness. 2009 Dec; 49: 424-31.

Branched-chain amino acid supplementation attenuates muscle soreness, muscle damage and inflammation during an intensive training program.

Matsumoto K, Koba T, Hamada K, Sakurai M, Higuchi T, Miyata H.
J Nutr Sci Vitaminol (Tokyo). 2009 Jun; 55: 288-91.

Effects of squat exercise and branched-chain amino acid supplementation on plasma free amino acid concentrations in young women.

Shimomura Y, Kobayashi H, Mawatari K, Akita K, Inaguma A, Watanabe S, Bajotto G, Sato J.
Int J Sport Nutr Exerc Metab. 2007 Dec; 17: 595-607.

Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise.

Greer BK, Woodard JL, White JP, Arguello EM, Haymes EM.
Int J Sports Med. 2007 Jun; 28: 531-8. Epub 2007 May 11.

Branched-chain amino acids and arginine supplementation attenuates skeletal muscle proteolysis induced by moderate exercise in young individuals.

Matsumoto K, Mizuno M, Mizuno T, Dilling-Hansen B, Lahoz A, Bertelsen V, Münster H, Jordening H, Hamada K, Doi T.
Med Sci Sports Exerc. 1998 Jan; 30: 83-91.

Branched-chain amino acids prolong exercise during heat stress in men and women.

Mittleman KD, Ricci MR, Bailey SP.
Sports Med. 1995 Sep; 20: 160-88.

Exercise and brain neurotransmission.

Meeusen R, De Meirleir K.
Amino Acids. 2001; 20: 1-11.

Plasma lactate, GH and GH-binding protein levels in exercise following BCAA supplementation in athletes.

De Palo EF, Gatti R, Cappellin E, Schiraldi C, De Palo CB, Spinella P.
J Sports Med Phys Fitness. 2000 Sep; 40: 240-6.

Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise.

Coombes JS, McNaughton LR.
Sports Med. 1999 Jun; 27: 347-58.

Leucine supplementation and intensive training.

Mero A.
and to allow maintenance of a high level of performance.
J Cell Biochem. 2010 May 12. [Epub ahead of print]

Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver.

Higuchi N, Kato M, Miyazaki M, Tanaka M, Kohjima M, Ito T, Nakamuta M, Enjoji M, Kotoh K, Takayanagi R.
Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.
Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB.
J Biol Chem. 2010 Apr 9; 285: 11348-56. Epub 2010 Jan 21.
http://jn.nutrition.org/cgi/content/full/135/6/1547S
Int J Sports Med. 2007 Jun; 28: 531-8. Epub 2007 May 11.

Branched-chain amino acids and arginine supplementation attenuates skeletal muscle proteolysis induced by moderate exercise in young individuals.

Matsumoto K, Mizuno M, Mizuno T, Dilling-Hansen B, Lahoz A, Bertelsen V, Münster H, Jordening H, Hamada K, Doi T.