Furosemide and liver damage

Furosemide is a drastic diuretic drug. If this drug is taken respecting the recommended doses it produces an "excellent therapeutic action in the face of modest side effects.

However, when these dosages are exceeded in the range of toxicity, severe undesirable effects appear. Furosemide, in fact, is metabolized by Cyt P450 giving a metabolite that has an epoxy group. The metabolite can be deactivated by other different reactions, but unfortunately if the amount of furosemide is high it remains in our body causing necrosis of the liver cells.

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