Serenoa repens

What is the Serenoa repens

Serenoa (Serenoa repens = Sabal serrulata = Serenoa serrulata) is the name of a palm that grows in the states bordering the southern Atlantic coast of the United States, in southern Europe and in northern Africa. This small palm (no more than 3 meters in height) produces dark red berries, monosem and similar in size to olives, which constitute its drug.

Healing properties

Against benign prostatic hyperplasia

Serenoa repens is now widely used in the treatment of benign prostatic hypertrophy and androgenic alopecia (hair loss sustained by endocrine disorders).Its active ingredients (triglycerides, phytosterols, sitosterol derivatives, flavonoids) give it antiandrogenic properties, which it carries out mainly through a "direct action on the dihydrotestosterone receptors, and indirectly, through the" inhibition of the 5-alpha-reductase enzyme.

So is DHT

Dihydrotestosterone (DHT) is the most powerful androgen hormone in the body and its activity is 4-5 times higher than the testosterone from which it derives.

Dihydrotestosterone is synthesized thanks to the action of the 5-alpha reductase enzyme which makes the double bond existing between carbon 4 and carbon 5 simple. consequently, the business.

The 5-alpha reductase enzyme is highly concentrated in the skin, liver, central nervous system (where the type 1 isoform is mainly present) and in the prostate (where the type 2 isoform is concentrated).

 

If produced in excess, dihydrotestosterone, by virtue of its strong androgenic power, promotes the appearance of acne, accelerates hair loss and causes prostatic hypertrophy. Hence the use of drugs capable of blocking the 5-alpha-reductase enzyme, derived from phytotherapy (such as Serenoa) or synthetic (such as finasteride), in the treatment of these conditions.

Unlike finasteride and dutasteride, which inhibit only one or both isoforms of the 5α-reductase enzyme, serenoa acts at a double level, blocking the enzyme on the one hand and preventing the interaction of DHT with its receptor from "other.

The inhibition of the 5-alpha-reductase enzyme, with consequent blocking of the conversion of testosterone to DHT, and of the binding between dihydrotestosterone and its receptor, have been demonstrated in vitro, but they seem too weak to be realized in vivo. All this is also supported by the fact that, although it is quite effective in solving the symptoms associated with benign prostatic hypertrophy, the drug does not lead to significant reductions in prostate volume.

Against androgenetic alopecia

This observation would also limit its effectiveness in the treatment of baldness of androgenic origin ("seborrheic alopecia") and acne. This does not mean, however, that the serenoa represents a valid adjuvant in the treatment of these conditions, to be used in combination with other products capable of enhancing their action or acting on different fronts.

Additional health applications

The serenoa also has anti-inflammatory and spasmolytic effects on the muscles of the urinary tract, tracing, in this sense, the "action of" another category of drugs used in the treatment of prostate hypertrophy and called alpha-blockers. Muscle contraction. in fact, prostatic gland favors obstruction of the urethra, responsible for urination disorders associated with IBP.
The sum of all these effects would be responsible for the clinical efficacy of serenoa in reducing the symptoms associated with prostatic hypertrophy, with an action comparable to that of finasteride. The tolerability of the drug would seem, however, even higher. The side effects associated with it. "use of serenoa are in fact generally rare and in any case mild; they include: itching, headache, hypertension, erectile dysfunction, decreased libido and gastrointestinal problems (nausea, vomiting, diarrhea, constipation).

Intake dose

The action of serenoa in the most accredited clinical studies was evaluated with extracts titrated and standardized in free fatty acids and phytosterols at 85-95%, at a dosage of 320 mg / day. The serenoa liposterolic extract is also available as a registered medicinal product (Permixon ®). Alternatively, the raw drug can be used in dosages of 1-2 grams per day.

La serenoa is found mainly as a single preparation, but in some products it can be associated with drugs with similar activity, such as pumpkin seeds, nettle or African pigeo.

Other articles on "Serenoa repens, prostate and hair"

1. Prostatic hypertrophy - Herbal medicine
2. Prostatic hypertrophy
3. Drugs for the treatment of Prostatic Hypertrophy
4. Diet for benign prostatic hypertrophy
5. Nettle and prostate health
6. Pumpkin seeds and prostate health
7. African pigeo

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