About Thermo X - Sictec Nutrition
THERMO X - SCITEC NUTRITION
Food supplement based on carnitine, tyrosine, caffeine, lipoic acid and Garcinia Cambogia extract.
FORMAT
Pack of 100 capsules
COMPOSITION
L-tyrosine; L-Carnitine; Garcinia Cambogia (66% extract); Alpha-Lipoic Acid; Caffeine; jelly.
Average analysis
For 100 g
per daily dose
% RDA
Product features Thermo X - Sictec Nutrition
Thermogenic: supplements that are born as adjuvants for weight loss, regulating one of the main mechanisms of energy expenditure of the human body: the production of heat. The field of action of these supplements is precisely thermogenesis, which significantly affects the daily energy requirement. the need to maintain a constant body temperature, while preserving the functional integrity of the internal organs, is an essential prerogative for the survival of man, for which one is willing to spend a real energy patrimony. In addition to a thermogenesis induced by cold , there is another "induced by the diet, which contributes about 10% to the total energy expenditure, and another" still - defined as optional - supported by a series of substances with sympathomimetic action. In general, the production of thermal energy is owes to the mitochondrial activity and the presence of futile cycles (a classic example is the thrill: that is, contractions of mus coli that do not lead to any useful movement, or metabolic cycles that do not lead to the production of any organic compounds).
Mitochondrial thermogenesis, particularly intense at the level of brown adipose tissue (preserved exclusively in small anatomical areas in the adult organism), allows the proton gradient normally used to guarantee the production of ATP to be dissipated in thermal energy, thanks to the presence of uncoupling proteins ( UCP) which reduce the efficiency of the mitochondrial chain.
Thermogenesis and overweight
The control of this physiological parameter is becoming increasingly important, as a series of alterations have been observed in pathological conditions such as obesity. More precisely, recent studies have shown that in the obese there is a flattening of induced thermogenesis, and how this can have a significant impact on weight gain, so much so as to induce the various pharmaceutical companies to invest in the search for new active ingredients capable of modulating this type of activity. energy, able to contribute significantly to weight loss The mechanisms through which these processes are carried out are not yet fully known, but today they represent a potential target of anti-obesity therapy.
It can therefore be easily deduced how these supplements find their meaning precisely in the induction of thermogenesis, and how this can be effective in weight loss. studied according to the physiological characteristics of the user.
Product composition in brief:
Thermo X - Sictec Nutrition
L-Carnitine 200mg: is a trimethylated amino acid underivate synthesized mainly in the liver and kidneys, which acts as a carrier of long-chain fatty acids at the level of the mitochondrial matrix to ensure their oxidation. Lipid metabolism plays a key role in the energy balance of the " organism, representing the primary source during mild aerobic activity. In these conditions, in fact, carnitine levels tend to decrease in favor of the acetylated form, indicating an increased need for this molecule. Consequently, an increase in carnitine levels in the muscles could increase the oxidation efficiency of lipids, ensuring an adequate and sustained energy supply. It should be noted, however, that in most cases the studies seem to agree on the absence of a real effect. metabolic in healthy individuals.
At high doses, episodes of insomnia, nausea, abdominal cramps, migraines and gastrointestinal disturbances, although rare, may occur.
L- Tyrosine 400 mg: polar amino acid not essential for humans. It is part of the synthesis of some hormones, such as thyroxine and catecholamines. The positive effect on the hormonal profile - which is found with an increase in the blood levels of these hormones - it seems to have a positive effect on both the psychic and physical spheres. The daily requirement is between 500 and 1500 mg, but an excessive intake could interfere with normal hormonal secretion.
Garcinia Cambogia Extract 200mg: its phytotherapeutic properties are due to the presence of hydroxycitric acid, which seems to interfere with normal lipid metabolism. In particular, by sequestering acetyl CoA, this substance prevents the synthesis of fatty acids, significantly reducing lipogenesis. and shifting the balance towards the glycogen synthesis, of which it induces it. Although there are no noteworthy side effects, the recommended dose of garcinia cambogia is between 500 and 2000 mg, titrated to 50% in hydroxycitric acid.
Alpha lipoic acid 100mg: the pure form, not associated with lysine (such as that found naturally in food), is able to easily cross the intestinal barrier and make itself available for 30/40% of the total amount taken. This cofactor is mainly concentrated in tissues with aerobic metabolism, such as muscles, heart, liver and brain. where it is part of numerous metabolic processes (oxidative decarboxylation, antioxidant and regenerative action) and where it appears, through independent insulin mechanisms, to improve glucose uptake. In sports, lipoic acid has been shown to be able to protect muscle tissue from damage induced by intense physical activity, and in determining a significant reduction in weight, even if this characteristic seems to be associated with the loss of lean mass. The antioxidant action is achieved at contained doses, while the metabolic action at more important doses, equal to 600mg / day; at doses above 1200 mg / day side effects such as itching, tingling and affections of the gastrointestinal tract (diarrhea, vomiting and cramps) have been documented.
Caffeine 200 mg: methylxanthine commonly introduced through coffee; an espresso can in fact contain up to 100mg. After taking, the caffeine is rapidly circulated and used by the various tissues. It therefore acts at different levels, on the stomach, favoring acid secretion, on the heart, increasing its frequency and contractile intensity, on the respiratory system, improving the ventilatory capacity, on muscle tissue, improving its contraction, and on the nervous system, increasing the secretion of catecholamines with consequent activation of the sympathetic system, which is important for supporting thermogenesis. The maximum safe dose used in the studies is 300 mg, beyond which they record tremors, anxiety, tachycardia, insomnia and excitement. Prolonged use, on the other hand, represents an important risk factor for pathologies of the gastrointestinal, cardiovascular and nervous tract (migraine).
Rationale for integrating Thermo X - Sictec Nutrition into sports practice
Unlike other thermogenics, which definitely focus on the effects of nerve and sympathomimetic substances, therefore effective in "increasing the optional induced thermogenesis, this supplement tries to associate a series of active substances on lipid metabolism, trying on the one hand to mobilize the lipid stocks and on the other to prevent their synthesis. In the literature there are no studies that test the synergistic efficacy of all these compounds, but there are some that show a strong antioxidant power of carnitine associated with alpha lipoic acid (so much so that it can be used in the treatment of some neurodegenerative diseases), and others which show an increase in oxidative metabolism following the simultaneous administration of carnitine and caffeine. Despite this, it is still difficult to express a definitive opinion on the real effectiveness of this product.
Method of use recommended by the company - Thermo X - Sictec Nutrition
Take 1 to 2 capsules a day avoiding, preferably before meals.
Method of use in sports - Thermo X - Sictec Nutrition
If the dosage proposed by the company seems to make the most sense in relation to the concentration of the individual active ingredients, it could instead be particularly advantageous to take the product an "hour before" training. This type of intake could guarantee an improved effect on performance, thanks to caffeine, but also greater oxidative protection, thanks to carnitine and alpha lipoic acid, and greater lipid oxidation efficiency in the immediate post-work-out.
Thermo X side effects - Sictec Nutrition
The presence of alkaloids and active ingredients capable of interfering with the hepatic enzyme chain, responsible for drug metabolism, could decisively alter the pharmacokinetic properties of certain active ingredients, enhancing or reducing their effects.
In the literature there is no specific indication about potential side effects associated with the administration of the product in question, therefore these should be traced back to the side effects of the individual components.
Precautions for use Thermo X - Sictec Nutrition
The Thermo X - Sictec Nutrition product is contraindicated in cases of kidney or liver disease, cardiovascular disease and / or hypertension, pregnancy, breastfeeding and under 12 years of age, as well as in adolescents not yet trained.
Thermo X - Sictec Nutrition must be used as part of an adequate low-calorie diet, following a healthy lifestyle with a good level of physical activity. If the diet is followed for prolonged periods of more than 3 weeks, it is advisable to seek medical advice.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical review of Thermo X - Sictec Nutrition.
Effects of carnitine coingested caffeine on carnitine metabolism and endurance capacity in athletes.
Cha YS, Choi SK, Suh H, Lee SN, Cho D, Li K.
Obesity (Silver Spring). 2010 May 6. [Epub ahead of print]
Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, Saito M.
The role and importance of brown adipose tissue in energy homeostasis.
Cypess AM, Kahn CR.
Curr Opin Pediatr. 2010 May 17. [Epub ahead of print]
Cold thermoregulatory responses following exertional fatigue.
Castellani JW, Sawka MN, DeGroot DW, Young AJ.
Front Biosci (Schol Ed). 2010 Jun 1; 2: 854-65.
Cellular bioenergetics as a target for obesity therapy.
Tseng YH, Cypess AM, Kahn CR.
Nat Rev Drug Discov. 2010 Jun; 9: 465-82. Review.
Adaptive reduction in thermogenesis and resistance to lose fat in obese men.
Tremblay A, Chaput JP.
Br J Nutr. 2009 Aug; 102: 488-92.
Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight.
Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL.
Am J Clin Nutr. 2008 Oct; 88: 906-12.
JD, Lovallo WR. Influence of grapefruit juice on caffeine pharmacokinetics and pharmacodynamics. Pharmacotherapy
16:1046-
Effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin
Pharmacol 35: 431-6.
R. K. Bhardwaj, H. Glaeser, L. Becquemont, U. Klotz, S. K. Gupta, M. F. Fromm.Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.. J. Pharmacol. Exp. Ther. 302: 645-5
www.smartdrug.com
Phytotherapy manuals
Effects of ingesting a commercial thermogenic product on hemodynamic function and energy expenditure at rest in males and females.
Wilborn C, Taylor L, Poole C, Bushey B, Williams L, Foster C, Campbell B.
Appl Physiol Nutr Metab. 2009 Dec; 34: 1073-8.
Acute effects of a thermogenic nutritional supplement on energy expenditure and cardiovascular function at rest, during low-intensity exercise, and recovery from exercise.
Ryan ED, Beck TW, Herda TJ, Smith AE, Walter AA, Stout JR, Cramer JT.
J Strength Cond Res. 2009 May; 23: 807-17.
The acute effects of the thermogenic supplement Meltdown on energy expenditure, fat oxidation, and hemodynamic responses in young, healthy males.
Jitomir J, Nassar E, Culbertson J, Moreillon J, Buford T, Hudson G, Cooke M, Kreider R, Willoughby DS.
J Int Soc Sports Nutr. 2008 Dec 16; 5: 23.
Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects.
Belza A, Frandsen E, Kondrup J.
Int J Obes (Lond). 2007 Jan; 31: 121-30. Epub 2006 Apr 25.
Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation.
Belza A, Jessen AB.
Eur J Clin Nutr. 2005 Jun; 59: 733-41.
