Generality
Phosphatidylserine is a structural phospholipid of biological membranes.
First isolated in the central nervous system, it was initially called cephalin.
Made up of two fatty acids linked to a glycerophosphate molecule, phosphatidylserine has carved out a respectable place in the clinical and nutritional fields, representing a molecule capable of supporting the structure and function of the central nervous system.
Indications
Why is Phosphatidylserine used? What is it for?
Phosphatidylserine is used in the clinical and integrative fields mainly for its neurotrophic and mental capacity support activities.
More precisely, phosphatidylserine would have proved useful in the management:
- Alzheimer's disease;
- Age-related memory disorders;
- Of senile dementia.
Still to be characterized would be the alleged ability of phosphatidylserine to counteract the stress induced by intense physical exercise and the resulting high levels of cortisol, responsible for a decline in both performance capabilities and the general state of health of the athlete.
Benefits and Properties
What benefit has phosphatidylserine shown during the studies?
Much of the results relating to the clinical efficacy of phosphatidylserine derive mainly from experimental studies.
However, in recent works the continuous use of phosphatidylserine supplements has been shown to be useful in improving the cognitive and mnemonic abilities of elderly subjects.
This activity seems to be related to the ability of phosphatidylserine to:
- stimulate the secretion of neurotransmitters;
- exert a direct protective action against the cell membranes of neurons.
In a very recent study conducted on 140 subjects with Alzheimer's disease, the use of 200 mg daily of phosphatidylserine would have, in a period of 3 months, statistically significantly improved mental abilities.
Some works, however still scarce in number and statistical scope, would also demonstrate the ability of phosphatidylserine - this time taken at dosages between 400 and 800 mg - to counteract the increase in blood concentrations of cortisol induced by intense physical exercise. It is possible to read this in-depth analysis, bearing in mind that the author adopts an excessively optimistic approach in listing the alleged (and yet to be demonstrated) anti-catabolic properties of phosphatidylserine.
Dosage and method of use
How to use phosphatidylserine
The dosages of phosphatidylserine most used in the various studies, therefore the best characterized, are 100 mg 3 times a day, to be taken preferably with meals.
Currently, much of the phosphatidylserine present in supplements is extracted from soy, by enzymatic conversion processes that allow the conversion of phosphatidylcholine into phosphatidylserine.
Side effects
The use of phosphatidylserine is generally safe and well tolerated.
Occasionally, however, gastrointestinal side effects such as nausea, abdominal cramps and dyspepsia have been observed.
Contraindications
When should phosphatidylserine not be used?
The use of phosphatidylserine is contraindicated in case of hypersensitivity to the active ingredient or to one of the elements present in the preparation.
Pharmacological interactions
What drugs or foods can modify the effect of phosphatidylserine?
There are currently no known active ingredients or foods capable of altering the normal activity of phosphatidylserine.
Precautions for use
What do i need to know before taking phosphatidylserine?
Given the absence of studies on the long-term safety profile of phosphatidylserine, it is not recommended for use in children, during pregnancy and in the subsequent period of breastfeeding.
Particular caution and close medical supervision in the use of phosphatidylserine would also be necessary in patients with antiphospholipid-antibody syndrome.
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