Creatine pyruvate - Scitec Nutrition

About Creatine Pyruvate - Scitec Nutrition

CREATINE-PYRUVATE - SCITEC NUTRITION

Food supplement based on creatine pyruvate

FORMAT
Pack of 100 capsules

COMPOSITION

Pyruvate creatine
Distilled water
Capsule: white gelatin
Anti-caking agent: magnesium stearate and talc

Per capsule: Creatine pyruvate 1400mg

Product Features Creatine Pyruvate - Scitec Nutrition

Creatine pyruvate is a molecule made up of creatine and pyruvic acid, linked together through covalent bonds. Also this form was born with the main objective of improving the solubility in aqueous environment, and reducing both the formation of background bodies and the metabolization to creatinine, both responsible for some of the most common side effects, such as abdominal cramps and diarrhea. Contrary to what happens for other forms of creatine, alternatives to monohydrate, for creatine pyruvate some studies are present in the literature that show an effective advantage deriving from its use, both in pharmacokinetic and ergogenic terms.

Creatine - key molecule for muscle metabolism; it is responsible for the energy supply in the early stages of contraction. Creatine introduced through the diet, or synthesized endogenously, reaches the muscle by penetrating the sarcoplasm, using specific sodium-dependent and insulin-induced membrane transporters. Arrived inside the skeletal muscle fiber. , where it is concentrated for more than 95%, creatine can easily cross the inner mitochondrial membrane and stop in the intermembrane space, where it is phosphorylated by creatine kinase into phosphocreatine. Phosphocreatine will leave the intermembrane space, taking to the myofibrils, where during the first minute of intense physical exercise, it will be able to transfer its phosphate group (high energy reserve) directly to the ADP, mediating the synthesis of ATP necessary to support the process During this process, part of the phosphocreatine will be hydrolyzed by a non-enzymatic mechanism into creatinine, and eliminated in the kidney with a clearance of around 2 grams per day.
The creatine introduced with the diet or through specific supplements, can assist the endogenous one in restoring the depleted muscle stocks. The ingestion of about 20 grams of creatine for at least 5 days, is in fact able to increase the pull of muscle creatine up to 17% and the phosphocreatine content of 7.6%, significantly improving the energy potential of the muscle.

Pyruvate - alpha keto acid also known as pyruvic acid, a fundamental crossroads of cellular energy metabolism. Produced for example following glycolysis, it can continue according to the oxidative path, originating acetyl CoA, necessary to support the Krebs cycle, or in the case of anaerobic conditions be fermented to lactate. As it is involved in the catabolic pathways, pyruvate also plays a key role in the control of anabolic phases, ensuring the synthesis of glucose through a process known as gluconeogenesis. Some studies have experimented its use in sports, obtaining good results in improving aerobic performance and in the resynthesis of glycogen.
At high doses, above 30 g / day, side effects can occur on the gastrointestinal tract.

Rationale for integrating Creatine pyruvate into sports practice - Scitec Nutrition

Among the alternative forms to creatine monohydrate, the one linked to pyruvate seems to be the most promising and the most characterized. In the literature, in fact, there are studies which not only evaluate the ergogenic efficacy of this form, but which even compare it to that of creatine monohydrate.

First, pharmacokinetic tests have shown - in addition to the best solubility in aqueous environment, with the reduction of side effects associated with the presence of insoluble residues - a more consistent plasma peak of creatine than that obtained with creatine monohydrate.

Administration of creatine pyruvate at 5 grams / day for 28 days has been shown to be particularly effective in improving peak strength by approximately 20% and in reducing the feeling of fatigue during interval training, possibly reducing ammonia production. accomplice of the onset of the feeling of fatigue.

Important improvements were obtained in the "adaptation to" anaerobic training and in body composition in the group of professional athletes treated with creatine pyruvate, compared to the group treated with creatine monohydrate.

However, it is necessary to mention 2 studies, in which creatine pyruvate did not produce any improvement in the athletic performance of competitive cyclists.

Method of use recommended by the company - Creatine pyruvate - Scitec Nutrition

It is recommended to take one capsule a day.

Directions for use in sports Creatine pyruvate - Scitec Nutrition

In the case of creatine pyruvate, no specific or in any case different dosages are defined compared to creatine monohydrate. However, in the studies published in the literature, the most replicated dosage is that of 5 grams / day for 28 days, capable of bringing about a significant improvement in aerobic performance. Even in this case, however, it may be possible to carry out a preventive loading phase for about 6 days at 0.3 gr per kg of lean mass / day, followed by prolonged maintenance for at least 3> weeks at 0.06 gr per kg of lean mass / die. In any case, the supplementation cycle should never exceed 4 weeks, as a reduction in the endogenous synthesis of creatine is well documented following prolonged supplementation over time.

Synergies Creatine Pyruvate - Scitec Nutrition

There are no specific studies that test the synergy between creatine pyruvate and other nutrients, therefore also in this case the published data for creatine monohydrate are reported.

Carbohydrates + Creatine: taken in the hour before the race, they guarantee an important energy support. Furthermore, the muscle uptake of creatine seems significantly enhanced by the insulin released following the intake of carbohydrates, with an increase of over 60% compared to the one obtainable with creatine alone.
Furthermore, some evidence shows an increase in the levels of the glucose transporter GLUT 4, on the muscle tissue following the intake of creatine, with an increase in the glycogen resynthesis capacity; this action could be used in the post-workout anabolic window.
Carbohydrates + creatine + proteins: guarantees an increase in absorption comparable to that present for simple carbohydrates only. In this case, however, there would be a potential advantage both on the nutritional intake of the snack and a reduction in the potentially dangerous glycemic peak.
CLA + creatine + proteins: at doses of 6 g, 9 g and 36 g respectively taken for 5 weeks, it has been shown to be effective in improving strength and increasing muscle mass by 3 - 4% in combination with strength training.
Arginine + Creatine: appears to provide a better ergogenic boost with an increase in maximum peak strength.

Side Effects Creatine Pyruvate - Scitec Nutrition

Various studies agree that creatine supplementation in healthy individuals is safe. In particular, studies relating to chronic (3-5 gr / day for a year) and acute (20 gr / day for a week) supplementation do not show any effects. particular collateral.
However, it should be remembered that the ingestion of too high or poorly solubilized doses could be accompanied by abdominal cramps, nausea, vomiting and diarrhea, as well as chronic administration, especially if carried out in conjunction with high-protein diets could significantly increase the renal load.
Finally, even if it does not represent a real side effect, it must be considered that the increase in weight resulting from the accumulation of water inside the cell could have a negative impact on performance.

Precautions for use Creatine pyruvate - Scitec Nutrition

The product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, during pregnancy, during lactation and under the age of 12 and adolescents not yet formed.
In case of prolonged use (over 6/8 weeks) the doctor's opinion is necessary.

This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of Creatine Pyruvate - Scitec Nutrition.