RILATEN ® is a rociverine-based drug
THERAPEUTIC GROUP: Spasmolytics / drugs for intestinal function disorders
Indications RILATEN ® Rociverina
RILATEN ® is effective in the symptomatic treatment of spastic-painful manifestations affecting the gastro-enteric, uro-genital and biliary tract.
Mechanism of action RILATEN ® Rociverina
RILATEN ® administered orally or rectally - is effectively absorbed in the gastrointestinal tract, distributed in the various anatomical areas without accumulation phenomena and subsequently excreted via the urinary route. The spasmolytic action of RILATEN ® is due to the presence of its active ingredient Rociverine, capable of combining an important myotropic effect with a neurotropic one. Experimental evidence, in fact, underlines how rociverine can exert a papaverine-like muscle relaxant action (inhibition of intracellular mechanisms of cell contraction), directed exclusively towards the smooth muscle fiber cells of the gastro-enteric and uro-genital system, maintaining the vascular function unaltered and at the same time carrying out an anticholinergic action (through competition with acetylcholine at the level of the receptors muscarinics, responsible for the violent and prolonged contraction that characterizes the spasm).
Studies carried out and clinical efficacy
1. ROCIVERIN AND IRRITABLE COLON SYNDROME
Minerva Med. May 1993; 84: 263-8.
[Treatment of irritable bowel syndrome with] rociverine
L Modena.
This all-Italian study, conducted on 40 patients with irritable bowel syndrome, shows how rociverine at a dose of 60 mg / day (therefore higher than the normally recommended one), can improve the symptoms of these patients with a sensitive and significant reduction of abdominal pain.
2. ROCIVERIN AND URINARY INCONTINENCE
Clin Ther. 1986; 8: 170-4.
Rociverine for nocturia in the elderly.
Daccó L, Intrieri L.
Also in this case an Italian study shows how the administration of only 20 mg / day of rociverine (active ingredient of RILATEN) can significantly reduce the volume and number of nocturnal evacuations due to urinary incontinence (in 40 patients between 50 and 80 years old). The somewhat positive results were even more interesting in light of the absence of clinically significant side effects.
3. ROCIVERINA AND COLIC
Minerva Med. 1982 Sep 8; 73: 2179-82.
[Therapy of acute spastic pain of the biliary and urinary tracts with rociverine]
Marsala F.
In this all-Italian study, the spasmolytic capacity of rociverine at 20 mg intravenously was observed, in reducing painful symptoms in 105 patients suffering from biliary and ureteral colic.
Method of use and dosage
RILATEN ® Rociverina 10mg dragees: it is recommended to take 1 dragee 3/4 times.
In case of acute episodes, and under strict medical supervision, it is possible to administer two confetti in a single dose.
RILATEN ® suppositories of 25mg of Rociverine: it is recommended to take 1 suppository 2/3 times a day.
RILATEN ® 2 ml ampoules with 20 mg of Rociverine: 1 ampoule to be administered intravenously, intramuscularly or by drip to be repeated if necessary at intervals of at least 2 hours.
Warnings RILATEN ® Rociverine
Belonging to the category of anticholinergic spasmolytics, RILATEN ® must also be administered with particular attention and under medical supervision in cardiopathic or arrhythmic patients, hypertensive, in debilitated subjects, in the elderly and in patients with mental disorders.
Cases are described in which the drug has been able to alter sight and normal perceptive abilities, therefore it is not recommended to use it before driving or before carrying out particular work.
PREGNANCY AND BREASTFEEDING
Although the use of RILATEN ® appears to be safe for the health of the woman and the unborn child, it is always advisable to avoid taking it during the first trimester of pregnancy, and to resort to the use of this drug during the entire gestation period. and breastfeeding only in case of real need and only after consulting your doctor.
Interactions
RILATEN ® can interact with various drugs such as tricyclic antidepressants, anticholinergics of various kinds, antihistamines, parasympathomimetics capable of altering their functionality, enhancing their effect and increasing the risk of glaucoma, urinary retention and other side effects.
Contraindications RILATEN ® Rociverine
It would be advisable to avoid taking RILATEN ® in case of hypersensitivity to the drug or to one of its components, glaucoma, pyloric stenosis, prostatic hypertrophy, intestinal atony of the elderly, reflux esophagitis and myasthenic syndromes.
Undesirable Effects - Side Effects
In subjects particularly sensitive to the active ingredient of RILATEN ® it is possible to observe, even at common therapeutic doses, atropinic effects such as:
- Dry mouth,
- Pupil dilation, with impaired normal vision,
- Drowsiness,
- Constipation
and in more serious cases:
- Chills and Tachycardia.
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