CONNETTIVINA PLUS ® is a drug based on Hyaluronic Acid + Silver Sulfadiazine
THERAPEUTIC GROUP: Antibiotics and chemotherapy for topical use
Indications CONNETTIVINA PLUS ® - Hyaluronic acid + Silver sulfadiazine
CONNETTIVINA PLUS ® is a medicine indicated in the local treatment of sores, burns, ulcers and dermatological lesions susceptible to bacterial infections.
Mechanism of action CONNETTIVINA PLUS ® - Hyaluronic acid + Silver sulfadiazine
CONNETTIVINA PLUS ® is a medicinal specialty particularly used in dermatology and surgery, especially in the prophylaxis of bacterial infections of traumatic lesions, burns and skin sores.
Its preventive-therapeutic action is due to the presence of the two active ingredients:
- Hyaluronic acid, a mucopolysaccharide particularly expressed in the connective tissue and in particular in the dermis, is fundamental in structuring the matrix by providing anatomical, functional and nutritional support to the overlying cellular elements. The correct supply of this substance has proved to be fundamental in accelerating the time healing favoring both the reconstitution of the dermis and the re-epithelialization of the lesion;
- Sulfadiazine Argentica, an active ingredient belonging to the family of sulfonamide antibiotics capable of inhibiting bacterial replication, thanks to the ability of the sulfadiazine radical to compete with the paraminobenzoic enzyme and to interfere with the bacterial synthesis of folic acid, and thanks to the presence of the ion Silver, useful in carrying out a broad spectrum bactericidal action, molecularly not yet characterized.
The various studies have underlined the preventive capacity of CONNETTIVINA PLUS ® especially against pathogens such as Pseudomonas aeuriginosa and Enterobacter piogenes, largely responsible for the infections found in wounds and burns.
Studies carried out and clinical efficacy
ARGENTIC SULFADIAZINE IN DIABETIC INJURIES
Minerva Med. 2012 Dec; 103: 533-9.
Impaired wound healing in diabetes: the rationale for clinical use of hyaluronic acid plus silver sulfadiazine.
Prosdocimi M, Bevilacqua C.
An all-Italian work that demonstrates how the topical use of hyaluronic acid and silver sulfadiazine can prove to be effective and safe in the prophylaxis of bacterial infections of diabetic lesions, especially when sustained by microorganisms normally resistant to common antibiotic therapy.
HYALURONIC ACID AND SILVER SULFADIAZINE IN SURGERY
J Cosmet Laser Ther. 2010 Feb; 12: 10-3.
Wound healing after laser skin resurfacing: the effect of a silver sulfadiazine-hyaluronic acid-containing cream under an occlusive dressing.
Kontoes PP, Vrettou CP, Loupatatzi AN, Marayiannis KV, Foukas PG, Vlachos SP.
Experimental study conducted on small laboratory guinea pigs that demonstrated how the use of creams based on hyaluronic acid and silver sulfadiazine can improve wound healing after laser surgery, significantly reducing infectious complications.
THE USE OF SILVER SULFADIAZINE AND HYALURONIC ACID IN BURNS
Curr Med Res Opin. 2005 Aug; 21: 1235-40.
Second-degree burns: a comparative, multicenter, randomized trial of hyaluronic acid plus silver sulfadiazine vs. silver sulfadiazine halo.
Costagliola M, Agrosì M.
Clinical trial that demonstrates how the association of silver sulfadiazine and hyaluronic acid may be more effective than silver sulfadiazine alone in improving the clinical course and prognosis of patients with second degree burns.
Method of use and dosage
CONNECTIVINA PLUS ®
Impregnated gauze 10x10, 10x20, 20x30;
200 mg cream of hyaluronic acid sodium salt + silver sulfadiazine 1 g per 100 g of product.
It is advisable to apply the correct amount of cream or medicated gauze on the lesion at least twice a day.
The use of CONNETTIVINA PLUS ® must be prolonged until the lesion is completely healed.
In order to optimize the therapeutic efficacy it is recommended to thoroughly cleanse the area before and after each application using sterile disposable gloves.
Warnings CONNETTIVINA PLUS ® - Hyaluronic acid + Silver sulfadiazine
Although the systemic absorption of the active ingredients contained in CONNETTIVINA PLUS ® is insignificant, it is advisable that the drug be used with caution in patients suffering from severe kidney diseases rather than hypersensitivity to the active ingredient or to one of its excipients.
It is also recommended to avoid direct exposure to ultraviolet rays during therapy with CONNETTIVINA PLUS ®.
PREGNANCY AND BREASTFEEDING
Given the absence of studies capable of fully characterizing the safety profile of Sulfadiazine Argentica for fetal health, it is recommended to avoid the use of CONNETTIVINA PLUS ® during pregnancy and in the subsequent lactation period unless it is essential.
Interactions
Patients receiving CONNETTIVINA PLUS ® should pay particular attention to the simultaneous on-site application of creams, ointments or solutions based on proteolytic enzymes.
Contraindications CONNETTIVINA PLUS ® - Hyaluronic acid + Silver sulfadiazine
The use of CONNETTIVINA PLUS ® is contraindicated in patients hypersensitive to the active principle or to one of its excipients.
Undesirable Effects - Side Effects
Although the use of CONNETTIVINA PLUS ® is generally safe and well tolerated, sometimes, especially following the continuous and extensive application of the drug, symptoms such as pain and burning on site and local reactions of an allergic nature may occur.
Note
CONNETTIVINA PLUS ® is a drug subject to mandatory medical prescription.
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