The cause of gangrenous pyoderma is not known, but this condition is frequently associated with systemic diseases, such as rheumatoid arthritis, hepatitis C, chronic inflammation of the intestine and malignant tumors. The onset of the disease is characterized by the appearance of small bumps or blisters that they develop into one or more open, painful ulcers surrounded by erythema.
The diagnosis of gangrenous pyoderma is based on the typical clinical picture and on the exclusion of other diseases that can manifest themselves in a similar way.
Regarding treatment, the most accredited options for controlling the symptoms of gangrenous pyoderma are represented by systemic corticosteroids and cyclosporine.
of this condition is unknown, but it probably depends on an "abnormal immune-mediated response.
Gangrenous pyoderma is characterized by recurrent skin ulcers and skin necrosis phenomena.
mediated by an abnormal immune response, in which the immune system reacts against the skin itself.Contrary to numerous other skin conditions in which lymphocytes and / or antibodies are involved, it has been observed that neutrophils are also involved in the gangrenous pyoderma and at the origin of the dysfunctional reaction of the immune system, there could be alterations in their chemotaxis.
In support of the hypothesis that the disease is immune-mediated, the overexpression of many mediators, including IL-8, TNF and interferon-γ, has been reported in patients with gangrenous pyoderma.
A characteristic of gangrenous pyoderma is pathergy, that is, the appearance of new lesions, in the trauma sites, due to the excessive reactivity of the skin to common and normally harmless stimuli.
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