About α-Lipoic 200 PRO ACTION
α-Lipoic 200 PRO ACTION.
Food supplement based on alpha-lipoic acid.
FORMAT
Bottle of 60 capsules, 388 mg each
COMPOSITION
ALIPURE Alpha Lipoic Acid: patented production method of alpha lipoic acid, free from solvent, which guarantees the highest degree of purity.
Corn starch: excipient able to stabilize the active principle and improve its absorption
Capsule: food gelatin
Dye: titanium dioxide.
Product features α-Lipoic 200 PRO ACTION
Alpha Lipoic Acid 200mg - also known as lipoate or ALA, it is a ubiquitous and essential molecule for proper cellular functioning.
Its many potentials have proved useful in the treatment of diabetic neuropathy, in the altered glucose metabolism in type II diabetics, in improving the lipid profile, in the treatment of hepatic, atheroschlerotic and cardiovascular diseases, and as a chelator of heavy metals.
The Italian research, in particular, has distinguished itself in providing interesting data on the experimentation of this molecule.
Potential benefits for sports use α-Lipoic 200 PRO ACTION
- Increase of the antioxidant capacity of the organism, fundamental in very intense athletic performance;
- Increase in lean mass;
- Accumulation of muscle glycogen stores;
- Increase of energy capacities;
- Reduction of fat mass.
However, the only effects demonstrated and present in the literature are those related to the enhancement of antioxidant capacities, with a significant reduction in markers of oxidative damage and lipoperoxidation, and with an increase in the reduced form, therefore antioxidant, of glutathione, after physical activity.
Method of use recommended by the company - α-Lipoic 200 PRO ACTION
1 capsule a day in a little water on a full stomach.
Method of use in sports α-Lipoic 200 PRO ACTION
There are various dosages proposed by the scientific literature.
In fact, between 200/400 mg per day, it has proved effective as an antioxidant, reducing the level of ROS (powerful oxidizing agents) and reducing the markers of oxidative damage.
In the treatment of diabetic neuropathy, however, its dosages can even exceed the gram, divided during the day.
Studies relating to the antioxidant capacity of lipoic acid in athletic performance show dosages of 600mg / day for 8 days.
An old study from 1996 shows how his blood level drops by 20% when taken on a full stomach compared to fasting; however, in the company presentation form it is recommended to take the capsule on a full stomach, to avoid heartburn.
How to optimize its activity - α-Lipoic 200 PRO ACTION
The potential applications of this molecule may be different, but it must be considered that not all of them have found scientific confirmation, and many have not even been tested.
Surely if you wanted to enhance its antioxidant power, it could be effectively associated with other antioxidants, such as vitamin E, vitamin C, glutathione and coenzyme Q10. The benefits of antioxidant cocktails have been described several times in the scientific literature, and also seem effective in countering the increase in muscle damage following intense physical activity, and facilitate the consequent recovery.
In sports practice, moreover, it is used to associate this molecule with chromium picolinate and with "acetyl L carnitine: this association could optimize the mitochondrial oxidative metabolism, both lipid and carbohydrate, definitely increasing the energy capacity of the muscle, and reducing the mechanisms that lead to lactate formation and the feeling of fatigue.
Attention!!!! The synergy between chromium picolinate and lipoic acid could significantly lower glycaemia (an action also documented by scientific studies), and induce an important hypoglycemia. Furthermore, a study shows how alpha lipoic acid, taken with creatine and sucrose, can increase muscle creatine pull, compared to creatine alone or creatine with sucrose after 5 days.
Rationale for use - α-Lipoic 200 PRO ACTION
The therapeutic effects of alpha lipoic acid in the treatment of numerous pathologies are well demonstrated.
Few studies have been carried out, however, on its application in the sports field: however, from these emerges the antioxidant role, which is carried out in the reduction of markers of muscle oxidative damage, and in the increase of important antioxidants such as glutathione in its reduced form.
On the other hand, regarding the association of antioxidants, the literature considers their activity to be effective in reducing oxidative damage both in pathological conditions and following physical activity, while the association between alpha lipoic acid and acetyl l carnitine has been documented in treatment of neurodegenerative diseases, in the reduction of mitochondrial function associated with age and in cardiovascular diseases, proving effective in reducing oxidative damage, but above all in preserving correct mitochondrial functionality.
Studies on the efficacy of their association in healthy individuals undergoing physical exercise are lacking.
Side effects α-Lipoic 200 PRO ACTION
At doses above 1200mg / day side effects such as itching, tingling and affections of the gastrointestinal tract (diarrhea, vomiting and abdominal cramps) have been documented.
Precautions for use α-Lipoic 200 PRO ACTION
Contraindicated in cases of renal, hepatic, diabetic, pregnancy and lactation pathology.
Interactions
Pharmacological - given the ability of lipoic acid to activate the intake of intracellular glucose, the simultaneous intake of hypoglycemic agents could have an unexpected and marked hypoglycemic effect; it is therefore necessary to consult your doctor before use.
Food - given the very similar structure to biotin, the two molecules could compete for the membrane transporter.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of α-Lipoic 200 PRO ACTION.
Int J Sport Nutr Exerc Metab. 2003 Sep; 13: 294-302.
Effect of alpha-lipoic acid combined with creatine monohydrate on human skeletal muscle creatine and phosphagen concentration.Burke DG, Chilibeck PD, Parise G, Tarnopolsky MA, Candow DG.
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer "s disease.
Shenk JC, Liu J, Fischbach K, Xu K, Puchowicz M, Obrenovich ME, Gasimov E, Alvarez LM, Ames BN, Lamanna JC, Aliev G.
J Neurol Sci. 2009 Aug 15; 283 (1-2): 199-206. Epub 2009 Apr 1.
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.
Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J.
Neurochem Res. 2009 Apr; 34: 755-63. Epub 2008 Oct 10.
Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.
McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF Jr, Vita JA.
J Clin Hypertens (Greenwich). 2007 Apr; 9: 249-55.
Mitochondrial membrane damage during aging process in rat heart: potential efficacy of L-carnitine and DL alpha lipoic acid.
Savitha S, Panneerselvam C.
Mech Aging Dev. 2006 Apr; 127: 349-55. Epub 2006 Jan 20.
Antioxidant therapy in human endocrine disorders.
Golbidi S, Laher I.
Med Sci Monit. 2010 Jan; 16: RA9-24. Review.PMID: 20037503 [PubMed - indexed for MEDLINE] Related citations
Antioxidant properties of an endogenous thiol: Alpha-lipoic acid, useful in the prevention of cardiovascular diseases.
Ghibu S, Richard C, Vergely C, Zeller M, Cottin Y, Rochette L.
J Cardiovasc Pharmacol. 2009 Nov; 54: 391-8. Review.
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM.
Biochim Biophys Acta. 2009 Oct; 1790: 1149-60. Epub 2009 Aug 4. Review.
Nutritional supplementation for type 2 diabetes: a systematic review.
Bartlett HE, Eperjesi F.
Ophthalmic Physiol Opt. 2008 Nov; 28: 503-23. Review.
Alpha-lipoic acid supplementation and diabetes.
Singh U, Jialal I.
Nutr Rev. 2008 Nov; 66: 646-57. Review.
Alpha-lipoic Acid Improves Endothelial Dysfunction in Patients with Subclinical Hypothyroidism.
Gd X, Jh P, Hl S, Ls Z.
Exp Clin Endocrinol Diabetes. 2010 Feb 16. [Epub ahead of print]
Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial.
Heinisch BB, Francesconi M, Mittermayer F, Schaller G, Gouya G, Wolzt M, Pleiner J.
Eur J Clin Invest. 2010 Feb; 40: 148-54. Epub 2009 Dec 27.
Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise.
Zembron-Lacny A, Slowinska-Lisowska M, Szygula Z, Witkowski K, Stefaniak T, Dziubek W.
J Physiol Pharmacol. 2009 Jun; 60: 139-43.
Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome.
Wray DW, Uberoi A, Lawrenson L, Bailey DM, Richardson RS.
Clin Sci (Lond). 2009 Mar; 116: 433-41.
Effects of antioxidant supplementation and exercise training on erythrocyte antioxidant enzymes.
Marsh SA, Laursen PB, Coombes JS.
Int J Vitam Nutr Res. 2006 Sep; 76: 324-31.
Endocr Pract. 2002 Jan-Feb; 8: 29-35.
Evans JL, Heymann CJ, Goldfine ID, Gavin LA.
Eur J Clin Pharmacol. 1996; 50: 513-4.
Gleiter CH, Schug BS, Hermann R, Elze M, Blume HH, Gundert-Remy U.