(or leukocytes) that play several roles in the "context of our immune defenses. Among these tasks the phagocytic capacity stands out, whose activation processes are not only involved in the classic defense against pathogens (infections), but also in the regulation of other physiological activities (coagulation) and / or pathological (atherosclerosis).
Monocytes are produced by the bone marrow and released into the bloodstream, where they remain for only a few hours, before migrating to the tissues where their action is required. At this level, they increase in size, enrich with lysosomes and differentiate into macrophages.
Like neutrophilic granulocytes, macrophages belong to the category of phagocytes; compared to the latter, they have a greater ability to incorporate and digest large or heavy particles. Highly specialized macrophages are present in various tissues, where they take on particular names, such as histiocytes (skin), Kupffer cells (liver), osteoclasts (bones), microglia (brain) and reticulo-endothelial cells (spleen).
Monocytes are distinguished from other white blood cells by their large size and by the oval or kidney-shaped nucleus.
Over the course of life, macrophages are capable of engulfing and digesting more than 100 bacteria; they are also able to remove larger cells (such as aged red blood cells and necrotic neutrophils) and unwanted particles, including coal and asbestos.
Macrophages are not able to immediately recognize all foreign substances, some of which are attacked only after the antibodies are bound to them, highlighting their danger.
Macrophages are part of a category of leukocytes called MHC class II (cells that present the antigen); in practice, after having digested the foreign elements, they process molecular fragments by inserting them on their cell membrane. recognized by particular white blood cells, called T helper lymphocytes, which perceive the danger and increase the body's immune response.
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Monocytes originate in the bone marrow and travel through the bloodstream to tissues throughout the body, where they mature and differentiate into MACROPHAGES. In addition, monocytes and macrophages stimulate other cells of the immune system by releasing enzymes, complement proteins and others. regulatory factors.
Monocytes can be evaluated with the leukocyte formula, a blood test that quantifies the number of white blood cells in one cubic millimeter of blood, also expressing the quantitative and percentage ratio of the various types of leukocytes.
Monocytes are produced by the bone marrow and released into the bloodstream, where they remain for only a few hours, before migrating to the tissues where their action is required. At this level, they increase in size, enrich with lysosomes and differentiate into macrophages.
Like neutrophilic granulocytes, macrophages belong to the category of phagocytes; compared to the latter, they have a greater ability to incorporate and digest large or heavy particles. Highly specialized macrophages are present in various tissues, where they take on particular names, such as histiocytes (skin), Kupffer cells (liver), osteoclasts (bones), microglia (brain) and reticulo-endothelial cells (spleen).
Monocytes are distinguished from other white blood cells by their large size and by the oval or kidney-shaped nucleus.
Over the course of life, macrophages are capable of engulfing and digesting more than 100 bacteria; they are also able to remove larger cells (such as aged red blood cells and necrotic neutrophils) and unwanted particles, including coal and asbestos.
Macrophages are not able to immediately recognize all foreign substances, some of which are attacked only after the antibodies are bound to them, highlighting their danger.
Macrophages are part of a category of leukocytes called MHC class II (cells that present the antigen); in practice, after having digested the foreign elements, they process molecular fragments by inserting them on their cell membrane. recognized by particular white blood cells, called T helper lymphocytes, which perceive the danger and increase the body's immune response.
