ZINC OXIDE UNGUENTO ® is a drug based on Zinc oxide.
THERAPEUTIC GROUP: Emollient and protective
Indications ZINC OXIDE UNGUENTO ® Zinc oxide
ZINC OXIDE UNGUENTO ® is used in the treatment of small skin disorders such as dermatosis and eczema.
Mechanism of action ZINC OXIDE UNGUENTO ® Zinc oxide
Zinc oxide, suitably mixed with specific buffers and acquired the pharmaceutical form of ointment, can be effectively and easily used in the treatment of minor dermatological pathologies such as eczema and dermatoses in general.
Different studies have demonstrated the therapeutic properties of this compound underlining the cytoprotective action against ultraviolet radiation, anti-irritant, healing and anti-inflammatory.
In spite of the defined therapeutic characteristics, the mechanism of action of zinc oxide has not yet been fully characterized, hypothesizing in addition to the crucial role of cofactor and catalyst also a modulator of gene expression, controlling the expression of the genes involved in inflammation.
Studies carried out and clinical efficacy
MOLECULAR MECHANISMS OF ZINC OXIDE
Nanotoxicology. 2012 Nov; 6: 757-65. doi: 10.3109 / 17435390.2011.620718. Epub 2011 Nov 17.
Independent cytotoxic and inflammatory responses to zinc oxide nanoparticles in human monocytes and macrophages.
Feltis BN, OKeefe SJ, Harford AJ, Piva TJ, Turney TW, Wright PF.
Molecular work that seeks to better characterize the mechanism of action of zinc oxide, highlighting a potential activity represented by the ability to recall and activate cellular elements capable of facilitating wound healing.
ZINC OXIDE INDUCED APOPTOSIS ON MELANOMA CELL LINES
Int J Nanomedicine. 2013; 8: 983-93. doi: 10.2147 / IJN.S42028. Epub 2013 Mar 6.
Induction of oxidative stress, DNA damage, and apoptosis in a malignant human skinmelanoma cell line after exposure to zinc oxide nanoparticles.
Alarifi S, Ali D, Alkahtani S, Verma A, Ahamed M, Ahmed M, Alhadlaq HA.
Yu KN, Yoon TJ, Minai-Tehrani A, Kim JE, Park SJ, Jeong MS, Ha SW, Lee JK, Kim JS, Cho MH.
Beautiful study that demonstrates how the treatment with zinc oxide based nanoparticles can present an important genotoxic action such as to induce apoptosis in melanoma cell lines.
ACUTE PANCREATITIS FROM INGESTION OF ZINC OXIDE
J Appl Toxicol. 2013 Feb 13. doi: 10.1002 / jat.2862. [Epub ahead of print]
Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions.
Seok SH, Cho WS, Park JS, Na Y, Jang A, Kim H, Cho Y, Kim T, You JR, Ko S, Kang BC, Lee JK, Jeong J, Che JH.
Experimental study that demonstrates the potential side effects of zinc oxide ingestion with the consequent appearance of serious adverse reactions such as acute pancreatitis.
Method of use and dosage
ZINC OXIDE UNGUENTO ®
10% zinc oxide ointment for skin use.
Local application of the appropriate amount of ointment is generally recommended, one or more times a day according to clinical needs.
Warnings ZINC OXIDE UNGUENTO ® Zinc oxide
Zinc oxide must only be used topically, therefore taking care to avoid ingestion or contact with mucous membranes.
If the application of the ointment does not determine appreciable results or rather favors the appearance of adverse reactions such as irritation and redness, it would be advisable to consult your doctor considering the possibility of suspending the therapy in progress.
It is recommended to store the drug in a cool, dry place out of the reach of children.
PREGNANCY AND BREASTFEEDING
The use of ZINC OXIDE UNGUENTO ® during pregnancy and breastfeeding should be justified only in cases of real need and take place under strict medical supervision.
Interactions
No clinically relevant drug interactions are currently known.
Contraindications ZINC OXIDE UNGUENTO ® Zinc oxide
The use of ZINC OXIDE UNGUENTO ® is contraindicated in patients hypersensitive to the active substance or to one of its excipients and in patients with peripheral circulatory disorders as well as in children under the age of 1 year.
Undesirable Effects - Side Effects
The use of ZINC OXIDE UNGUENTO ® could determine the appearance of local adverse reactions such as redness, burning and irritation.
Note
ZINC OXIDE UNGUENTO ® is a drug not subject to mandatory medical prescription.
The information on ZINC OXIDE UNGUENTO ® Zinc oxide published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.
