Fluoroquinolones exert a broad spectrum bactericidal action, therefore, they are effective in counteracting infections sustained by both Gram-positive and Gram-negative bacteria.
Depending on the case, fluoroquinolones can be administered orally, parenterally, inhaled, ocular (eye drops, ophthalmic ointment) or auricular (ear drops). Medicines containing fluoroquinolones can only be dispensed upon presentation of a specific medical prescription. Depending on the pharmaceutical formulation and the type of active ingredient contained in the medicinal product, the medical prescription can be repeatable or limited (sold to the public on prescription from hospitals or specialists). Furthermore, it should be remembered that some fluoroquinolone-based medicines are for hospital use only.
, both Gram-positive and Gram-negative (broad spectrum of action).
The discovery of fluoroquinolones aroused immediate enthusiasm due to their wide spectrum of action; enthusiasm which, however, has gradually faded due to the appearance of resistance phenomena and the discovery of problems regarding their safety of use. (more detailed information is given in the dedicated chapters "Toxicity" and "Resistance"). Despite this, there are several active ingredients belonging to the group of fluoroquinolones still used in therapy today.
