Biguanides and metformin

Oral hypoglycemic drugs of the biguanide class

Biguanides are oral hypoglycemic drugs that can reduce blood glucose even in the absence of pancreatic B cell function. Phenformin (a biguanide) was removed from the US market due to the high incidence of lactic acidosis. In 1995, metformin was introduced. , which is a less toxic biguanide.

Metformin-based drugs:

• METFORAL ® Metformin
• GLUCOPHAGE ® Metformin

Metformin

Like other biguanides, it is prescribed to patients with resistant obesity, whose hyperglycemia is due to insulin ineffectiveness. advantages over insulin or sulfonylureas for the treatment of hyperglycemia in such patients. The most frequent toxic effects of metformin are gastrointestinal: anorexia, nausea, vomiting, abdominal pain, diarrhea. 20% of patients are affected.

Pharmaceutical specialties containing metformin: Glucophage ® Metbay ® Metforal ® Metiguanide ®

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