serum glutamic oxaloacetic), is an intracellular, cytoplasmic and mitochondrial enzyme, detectable in many tissues.
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The higher concentrations of aspartate transaminase are especially appreciated in the heart and liver; On the other hand, AST concentrations are lower in skeletal muscle, and even more so in the brain, kidney, pancreas, lung and red blood cells. Consequently, the blood content of GOT increases whenever cell damage occurs, up to necrosis, of the mentioned tissues.
In particular, the blood aspartate transaminase assay is widely used to evaluate liver function.
accumulated by the ability to catalyze the conversion of aspartate and alpha-ketoglutarate into oxaloacetate and glutamate, and vice versa:
Oxaloacetate + glutamate ↔ aspartate + α-ketoglutarate
