This pathology is caused by an "alteration of the secretion or normal outflow into the duodenum of bile, a dense yellow-green substance, which is produced by the liver to allow digestion and absorption of fats. This involves the pouring into the blood of bile salts and other colophilic compounds, such as bilirubin, normally secreted in the bile.
The main symptom of cholestasis gravidarum is intense and persistent itching. This manifestation is usually early and is not associated with a skin rash. The itch of cholestasis gravidarum can affect any part of the body, but it usually begins in the palms of the hands and soles of the feet, and then generalizes to the whole body. In the presence of this characteristic itchy sensation, confirmation of the diagnosis is obtained with specific blood tests, such as the measurement of bile acids, bilirubin and transaminases.
Left untreated, cholestasis gravidarum can have serious consequences for both the mother and the fetus. These include: increased risk of fetal prematurity, death at birth and respiratory distress syndrome.
The management of gravidic cholestasis involves the intake of drugs useful to avoid the accumulation of bile acids in the bloodstream and the induction of childbirth.
and steatorrhea. In the presence of this disorder, it is also possible to find an alteration in the parameters of liver function.
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