What is Quercetin
Quercetin, or quercetin if you prefer, is a ubiquitous flavonoid present in a great variety of fruits (apples, grapes, olives, citrus fruits, berries), vegetables (tomatoes, onions, broccoli, capers), drinks (tea and red wine) and herbal extracts.
In nature, quercetin is not present in the isolated form but as an aglycone (non-sugar part) of various glycosides, including rutin and quercitrin; in this form it abounds, in particular, in extracts of horse chestnut, gingko biloba, calendula, hawthorn, chamomile, lovage and hypericum.
Property
Known to the general public for its high antioxidant and anti-inflammatory power, quercetin is proposed as a dietary supplement within antiaging and antioxidant formulations.
Various and numerous studies demonstrate its potential usefulness in the treatment and prevention of various morbid and non-morbid conditions.
Premature skin aging
action attributable to the ability - expressed both orally and by topical application - to counteract the negative activity of solar radiation; the latter, in fact, lead to the synthesis of reactive oxygen species (free radicals) capable of producing structural alterations in the synthesis of collagen and elastin by dermal fibroblasts;
Diseases in which oxidative stress and chronic inflammation play a leading role
allergies, insulin resistance, atherosclerosis, arthritis, Alzheimer's disease, psoriasis, lupus and many of the diseases related to aging; quercetin inhibits numerous phases that lead to the release of histamine and the production of pro-inflammatory prostaglandins and leukotrienes, as well as the enzymes 5-lipoxygenase and phospholipase A2. At the same time it exerts a powerful direct and indirect antioxidant action, protecting the activity of the endogenous antioxidant enzymatic systems: catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase.
The reduction of cardiovascular risk can be favored by the antiplatelet and antithrombotic activity of quercetin.
Quercetin may also help prevent cancer (can be used alongside chemotherapy as an adjunct; consult your doctor). In vitro and on animal models it has in fact been shown to be able to arrest the growth or even lead to apoptosis (cell death) colonies of tumor cells of different origins in different stages of replication.
Hemorrhoids, venous insufficiency and capillary fragility
well known is the ability of glucosides such as rutin to act as anti-haemorrhagic and anti-edema with an important therapeutic role in the presence of haemorrhoids, varicose veins and typical manifestations of venous insufficiency (night cramps, pains, heaviness and swelling in the legs).
Effectiveness
The supplementation with quercetin can therefore help to reduce the formation of free radicals and pro-inflammatory substances, revealing itself to be a precious help for our health. animals - there are no wide-ranging clinical studies that confirm the usefulness of quercetin in the treatment of the aforementioned diseases. The research activities, however, are particularly intense, given the numerous publications, including recent ones, which can be found on pubmed.
How to use
The recommended intake doses are around 500 mg / day. The daily dietary intake is estimated at about 30 mg for subjects with Western dietary habits. The glycosylated forms are more absorbed than isolated quercetin; the study of the pharmacokinetics and bioavailability of the various administrable forms will play a crucial role in the development of therapeutic potential of the molecule.
Contraindications
The antiplatelet and antithrombotic activity requires caution in the use of quercetin by patients treated with antiplatelet agents (Aspirinetta, CardioAspirin) and oral anticoagulants (Coumadin, Sintrom). Some in vitro studies have ascribed a "mutagenic activity to quercetin, not confirmed by long-term in vivo studies."
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