About Thermo Stack 2 - Maximize
THERMO STACK 2 - MAXIMIZE
Food supplement based on plant extracts
FORMAT
Pack of 60 capsules
COMPOSITION
White willow (Salix alba, bark) dry extract tit. 27% salicin, shell: edible gelatin; guarana (Paullinia cupana, seeds) dry extract tit. 22% caffeine; Citrus aurantium var. bitter peel of fruits dry extract tit. 20% synephrine; cola nuts (Cola nitida, seeds) dry extract tit. 10% caffeine; dye: E171.
Medium content in characterizing elements
For 2 cps
White Willow dry extract
250 mg
Guarana e.s.
450 mg
intake in Caffeine
99 mg
Citrus Aurantium e.s.
300 mg
intake in synephrine
30 mg
Cola Noci e.s.
300 mg
intake in Caffeine
30 mg
Product features Thermo Stack 2 - Maximize
Thermogenic: they are supplements that are born as adjuvants in the slimming process, acting on one of the crucial mechanisms in weight control. Thermogenesis, in fact, necessary to guarantee body temperature and the correct functionality of internal organs, represents one of the activities that have the greatest impact on the daily energy balance. In fact, it has been estimated that only diet-induced thermogenesis, that is the energy involved in digesting, absorbing and metabolizing nutrients, represents 10% of the daily energy requirement. However, alongside this that we could define as obligatory, there is a "another thermogenesis, called optional, modulated by a series of molecules capable of enhancing the sympathetic activity of the nervous system, and interacting with cell receptors by enhancing the activity of some biological pathways. And this is precisely the target of thermogenic supplements, capable of mimicking the action of catecholamines or inducing their synthesis, and modulating the adrenergic activity by intervening in particular on the Beta 3 receptors, responsible for lipogenesis at the level of adipose tissue. The latter, in fact, and in particular a variety of it known as brown or multilocular adipose tissue - maintained in the axillary, mediastinal, inguinal and cervical areas - thanks to the presence of uncoupling proteins, can dissipate much of the proton gradient generally used in thermal energy. for the synthesis of ATP, thus ensuring an increase in body temperature.
This energy expenditure, if associated with a low-calorie diet and other variables capable of further increasing the daily requirement, can significantly affect the general organic economy, facilitating weight loss.
Although theoretically everything seems somewhat linear, it should be emphasized that the reduction in food intake is read by the body as a "deficiency", which causes it to improve its metabolic efficiency, with negative repercussions on thermogenesis, already reduced in its component linked to diet, counteracting the continuation of weight loss. If we add to this a series of alterations and a flattening of thermogenesis in obese individuals, we can easily understand how in itself, this process represents a limit but at the same time an important field of improvement for the understanding of the complicated mechanisms that control the balance needle.
Product composition in brief:
Thermo Stack 2 - Maximize
White willow: the phytotherapeutic importance is linked to the presence of salicylates in its bark, including salicin, an analogue of acetylsalicylic acid with the same anti-inflammatory, antifebrile and pain-relieving properties, but without its side effects (irritation of the gastric mucosa and increased blood fluidity). Alone, salicin has not proved particularly active in assisting weight loss, but administered together with other substances (xanthines in particular), it seems to be able to promote their anorectic and thermogenic activity.
Particular attention should be paid when using it in subjects allergic to salicylates.
Guarana: the energizing and stimulating effects linked to this plant are due to the presence of guaranine (analogue of caffeine) and of the same caffeine. Of course, all the benefits (increased heart rate and tension, mental clarity, improved digestion, analgesic, diuretic and naturally thermogenic properties) are traceable to those of caffeine, thanks to a "sympathomimetic action. Excessive doses of guarana, considering that on average it contains 4-5% of guaranine, could have repercussions on the cardiovascular system (tachycardia, extrasystoles) and nervous system (anxiety, hyperexcitability and agitation).
Citrus Aurantium: Southeast Asian plant rich in flavonoic glycosides, coumarin, aldehydes and monoterpenes. Synephrine and octopamine are among the most biologically active ingredients. Their effects are realized in:
- Sympathomimetic action: they are able to activate alpha 1 adrenergic receptors and induce peripheral vasoconstriction;
- Thermogenic action: no experimental evidence shows the ability of these principles to act on beta 3 receptors and induce lipogenesis.
Various disorders are associated with the assumption of large doses of synephrine, from tremors to headaches, from tachycardia to hypertension, up to arrhythmias and cardiac arrest; however, the potentially dangerous quantities are not known.
Cola nuts and Caffeine: fruit of the cola plant, belonging to the same family as cocoa. The particularly bitter taste of cola is due to the presence of methylxanthines, in particular caffeine. This, once put into circulation, is used by various tissues and acts at the level of the stomach, favoring acid secretion, of the heart, increasing its frequency and intensity, of the respiratory system, improving the ventilatory capacity, of the muscle tissue, improving blood contraction and perfusion, of the urinary system, ensuring vasodilation of the arterioles and facilitating filtration, and of the nervous system, increasing the secretion of catecholamines with consequent activation of the sympathetic (important for supporting thermogenesis). The maximum safe dose used in the studies is 300 mg, beyond which there is tremor, anxiety, tachycardia, insomnia and arousal. The prolonged use of caffeine, on the other hand, represents an important risk factor for pathologies of the gastro intestinal, cardiovascular and nervous tract (migraine).
Rationale for integrating Thermo Stack 2 - Maximize into sports practice
This type of supplement can rightfully be included in the category of thermogenics. These supplements must be distinguished from the so-called fat burners, as they do not include in their composition substances capable of altering the oxidative lipid metabolism. Their main effect, as shown by some studies, is expressed through the induction of thermogenesis, thus guaranteeing the increase in energy expenditure necessary to assist the slimming phase. Of course, in order for these products to guarantee tangible results, they must necessarily be associated with a low-calorie diet and a "programmed physical activity, also because, as can be seen from the critical rereading of various works, and as can be easily deduced from" common experience , the advantages that would derive from an increased energy expenditure would be completely in vain if associated with an "overeating.
Method of use recommended by the company - Thermo Stack 2 - Maximize
Take 1 to 2 capsules a day, preferably avoiding the evening.
Method of use in sports - Thermo Stack 2 - Maximize
Also in this case it is necessary to refer to the dosage suggested by the manufacturer; however, the energizing effects of the various products could also be exploited to improve performance. In this case it would be enough to take the daily dose a few minutes before training, given the rapid kinetics that characterize these molecules.
Thermo Stack 2 Side Effects - Maximize
The presence of alkaloids, and of active ingredients capable of interfering with the hepatic enzyme chain responsible for drug metabolism, could significantly alter the pharmacokinetic properties of certain active ingredients, enhancing or reducing their effects.
In the literature there is no specific indication about potential side effects associated with the administration of the product in question, therefore these should be traced back to the side effects of the individual components.
Precautions for use Thermo Stack 2 - Maximize
The Thermo Stack 2 - Maximize product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, pregnancy, lactation and under 12 years of age, as well as in adolescents not yet trained.
The Thermo Stack 2 - Maximize product must be used as part of an adequate low-calorie diet, following a healthy lifestyle with a good level of physical activity. If the diet is followed for prolonged periods of more than 3 weeks, it is advisable to seek medical advice.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of Thermo Stack 2 - Maximize.
Effects on the Human Body of a Dietary Supplement Containing L-Carnitine and Garcinia cambogia Extract: A Study using Double-blind Tests.
Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T.
J Clin Biochem Nutr. 2008 Mar; 42: 89-103.
Genes Nutr. 2008 Feb; 2: 353-8.
Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park T.
Rev Salud Publica (Bogota). 2008 Nov-Dec; 10: 818-30.
[Article in Spanish]
de Lira-García C, Souto-Gallardo M, Bacardí-Gascón M, Jiménez-Cruz A.
[Role of phytotherapy in the prevention and treatment of obesity]
Balázs A.
Orv Hetil. 2010 May 9; 151: 763-73. Review. Hungarian.
J Nutr Sci Vitaminol (Tokyo). 2001 Dec; 47: 378-84.
Cha YS, Choi SK, Suh H, Lee SN, Cho D, Li K.
Obesity (Silver Spring). 2010 May 6. [Epub ahead of print]
Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, Saito M.
The role and importance of brown adipose tissue in energy homeostasis.
Cypess AM, Kahn CR.
Curr Opin Pediatr. 2010 May 17. [Epub ahead of print]
Cold thermoregulatory responses following exertional fatigue.
Castellani JW, Sawka MN, DeGroot DW, Young AJ.
Front Biosci (Schol Ed). 2010 Jun 1; 2: 854-65.
Cellular bioenergetics as a target for obesity therapy.
Tseng YH, Cypess AM, Kahn CR.
Nat Rev Drug Discov. 2010 Jun; 9: 465-82. Review.
Adaptive reduction in thermogenesis and resistance to lose fat in obese men.
Tremblay A, Chaput JP.
Br J Nutr. 2009 Aug; 102: 488-92.
Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight.
Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL.
Am J Clin Nutr. 2008 Oct; 88: 906-12.
JD, Lovallo WR. Influence of grapefruit juice on caffeine pharmacokinetics and pharmacodynamics. Pharmacotherapy
16:1046-
Effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin
Pharmacol 35: 431-6.
R. K. Bhardwaj, H. Glaeser, L. Becquemont, U. Klotz, S. K. Gupta, M. F. Fromm.Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.. J. Pharmacol. Exp. Ther. 302: 645-5
www.smartdrug.com
Phytotherapy manuals
Effects of ingesting a commercial thermogenic product on hemodynamic function and energy expenditure at rest in males and females.
Wilborn C, Taylor L, Poole C, Bushey B, Williams L, Foster C, Campbell B.
Appl Physiol Nutr Metab. 2009 Dec; 34: 1073-8.
Acute effects of a thermogenic nutritional supplement on energy expenditure and cardiovascular function at rest, during low-intensity exercise, and recovery from exercise.
Ryan ED, Beck TW, Herda TJ, Smith AE, Walter AA, Stout JR, Cramer JT.
J Strength Cond Res. 2009 May; 23: 807-17.
The acute effects of the thermogenic supplement Meltdown on energy expenditure, fat oxidation, and hemodynamic responses in young, healthy males.
Jitomir J, Nassar E, Culbertson J, Moreillon J, Buford T, Hudson G, Cooke M, Kreider R, Willoughby DS.
J Int Soc Sports Nutr. 2008 Dec 16; 5: 23.
Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects.
Belza A, Frandsen E, Kondrup J.
Int J Obes (Lond). 2007 Jan; 31: 121-30. Epub 2006 Apr 25.
Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation.
Belza A, Jessen AB.
Eur J Clin Nutr. 2005 Jun; 59: 733-41.
