About Melatonin 5 mg - Natroid
Melatonin 5 mg- Natroid
Food supplement based on Melatonin and vitamin B6
FORMAT
Pack of 100 tablets
COMPOSITION
cellulose; dicalcium phosphate (E341); filming agent; hypromellose (E464); magnesium stearate (E572); stearic acid (E570); silicon dioxide (E551); methylcellulose (E461), glycerol (E422), pyridoxine hydrochloride and melatonin.
PER CAPSULE: Melatonin 5 mg; Vitamin B6 3 mg
Product features Melatonin 5 mg - Natroid
Melatonin: neurohormone produced by the pineal gland, located at the diencephalic level, which carries out its biological action by recognizing and activating MT receptors, disseminated throughout the central nervous system and particularly concentrated at the hypothalamic level. In nature, melatonin is not present exclusively in animal organisms, but is also found in various plants, such as cocoa and rice, from which it is extracted for commercial purposes. The sources of food melatonin, however, are not able to significantly increase the plasma levels of this molecule, whose concentration oscillates between 10 and 300 pg / ml; for this reason, for the purpose of a correct supplementation it is necessary to resort to supplements.
Endogenous synthesis: the synthesis of melatonin is carried out at the level of the pineal gland, starting from tryptophan through the enzyme serotonin N acetyl transferase. The maximum peak of production occurs during the night period, when the light, through molecular mechanisms not entirely clear, but which require the participation of photoceptors and AMPc, is able to inactivate the enzyme serotonin acetyl transferase. The aging of the epiphysis, characterized by diffuse calcification and nervous desensitization, leads to a gradual decrease in its biosynthetic capacity.
Kinetics: melatonin taken orally passes unaltered in the intestine, where it is almost totally absorbed (absorption levels drop by 50% in the elderly) and transported to the liver. The first pass metabolism determines the conversion of about 90% of the total amount taken into 6 sulfatoxy melatonin, the inactive metabolite eliminated in the kidney. The bioavailable quota determines a maximum plasma peak after about 3 hours, even if this is profoundly influenced by the state of gastric repletion (stomach dilation).
Functionality: Melatonin is mainly involved in the regulation of biological rhythms. In fact, its hypnotic and sedating action, which manifests itself through the activation of MT receptors, mainly concentrated at the hypothalamic level, is able to facilitate falling asleep and restorative rest. In addition to the classic role, moreover, melatonin is directly involved:
- In the protective action against reactive oxygen and nitrogen species;
- in strengthening the immune defenses;
- in glucose metabolism;
- in the protection and prevention of damage at the level of nucleic acids.
Role of the supplement: the melatonin supplement is effectively used both in all syndromes characterized by sleep disorders (work shifts, jet-lag) and in the prevention of epiphysial degeneration. Several studies have in fact shown how supplementation with melatonin can reduce the functional exhaustion of the pineal gland, and preserve its functionality for longer. Several researchers are also evaluating other applications for metabolic pathologies, endocrine disorders and neurodegenerative diseases.
In sports: although not widely used in sports, melatonin seems to be able to support the athlete's body especially during the most intense workouts:
- avoiding the drop in immune defenses that occurs following overtraining;
- directly supporting the antioxidant capacity of the organism;
- improving hormonal function: studies show a significant increase in the nocturnal secretion of growth hormone;
- reducing body temperature during intense workouts performed in hot environments.
Despite this, there is a lack of data showing a significant improvement in performance or body composition.
Vitamin B6:also known as pyridoxine, it is a pyridine derivative introduced mainly through meat, absorbed in the fasting after ATP-dependent hydrolysis and transported to the liver bound to albumin. Here it is transformed into pyridosamine and then into pyridoxal and subsequently phosphorylated, with consequent activation and storage. From the liver it will be transported to the various tissues, where it can carry out its biological role, as a cofactor:
- It increases blood glucose levels: it favors glycogenolysis and gluconegoenesis;
- Promotes the synthesis of neurotransmitters such as serotonin, dopamine, norepinephrine and GABA.
- Guides the synthesis of the heme group, necessary for hemoglobin to bind oxygen;
- It allows the synthesis of niacin, starting from tryptophan;
- Modulates the hormonal action;
Vitamin B6 is used in the treatment of numerous diseases, with particular importance for neurodegenerative, cardiovascular and immune disorders.
Its daily requirement is around 1 / 1.5 mg, but even in this case, deficiency episodes are very rare.
Vitamin B6 and melatonin: although not all studies seem to agree on this, vitamin B6 has been found to be effective in enhancing the synthesis of melatonin, so much so that pyridoxine deficiency inevitably affects the plasma levels of this hormone. In addition to the direct role towards synthesis, this synergy could also be advantageous for the control of many common metabolic and functional pathways.
Method of use recommended by the company - Melatonin 5 mg - Natroid
Take one tablet in the evening 20 minutes before bedtime.
Directions for use in sports Melatonin 5 mg - Natroid
Studies conducted on healthy individuals undergoing physical exercise generally use very different dosages. In fact, it seems that an effect, in terms of improving the hormonal balance, can be had both at low concentrations (0.3 / 0.5 mg) and at higher concentrations 3/5 mg.
In both cases, however, it is necessary to take melatonin before going to bed, in order to reproduce and improve the endogenous production of the hormone, without causing an upset of the delicate circadian and ultradian rhythms.
Synergy - Melatonin 5 mg - Natroid
Several studies seem to agree on the greater effectiveness of the synergy when taken together with zinc. A generalized improvement is in fact obtained both on the strengthening of the immune defenses and on the antioxidant effect and on the metabolic aspect, improving the sensitivity to insulin.
Side Effects Melatonin 5 mg - Natroid
Although recent studies have confirmed the high tolerability and safety of the active ingredient, there are cases in the literature in which, even at a dose of 3 mg / day, nausea, irritability, nightmares and vascular alterations have been observed.
Furthermore, by acting as a mild hypnotic and sedative, melatonin may interfere with the ability to concentrate. By enhancing the immune response, the substance could also worsen the conditions of patients with allergic or autoimmune diseases.
Precautions for use Melatonin 5 mg - Natroid
The product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, allergies and autoimmune diseases, during pregnancy, during lactation, under the age of 12 and for adolescents not yet trained.
In case of prolonged use (over 6/8 weeks) the doctor's opinion is necessary.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of Melatonin 5 mg - Natroid.
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