PYRALVEX ® Salicylic acid + glucosidic extract of rhubarb

PYRALVEX® is a drug based on salicylic acid + glycosidic extract of rhubarb

THERAPEUTIC GROUP: Antiinfectives and antiseptics for local oral treatment

Indications PYRALVEX ® Salicylic acid + glucosidic extract of rhubarb

PYRALVEX® is a drug indicated as a local antiseptic in the course of infections of the oral cavity such as gingivitis, stomatitis, oro-pharyngitis and alveolar pyorrhea.

Mechanism of action PYRALVEX ® Salicylic acid + glucosidic extract of rhubarb

The antiseptic and anti-infective action of PYRALVEX® is due to the presence of two important active ingredients, used in this case for local use: salicylic acid and rhubarb extract.
Salicylic acid is a carboxylic acid of natural origin, with a natural exfoliating and anti-inflammatory activity, which in small doses and for topical use is important for its keratolytic and bacteriostatic effect, therefore useful in controlling the evolution of inflammatory and infectious.
The high irritating power, towards the gastric mucosa, obviously limits it, limiting it to the topical route.
The carbohydrate extract of rhubarb, on the other hand, has a high anti-inflammatory and analgesic activity, useful in soothing the mucosa subjected to the inflammatory stimulus, facilitating its recovery and at the same time also guaranteeing an improvement in the clinical picture.
Recent scientific evidence has attributed to this last active ingredient also an antiseptic and antibacterial activity, particularly effective against gram positive and gram negative bacteria of the oral cavity, and facilitated by the presence of salicylic acid, which guarantees a greater permeability of these extracts in the mucosa subjected to microbiological action.

Studies carried out and clinical efficacy

THE PYRALVEX IN CLINICAL PRACTICE
Treatment results of various oral diseases wih the preparation Pyralvex.
Maresch-Lewandowska M.
Czas Stomatol. 1981 Oct; 34: 1013-5. Polish.

Dated work that demonstrates the efficacy of the association between salicylic acid and rhubarb extract in the treatment of infectious diseases of the oral cavity, resulting generally well tolerated.

PYRALVEX AND AFTE OF THE ORAL CAVITY
Inf Dent. 1977 Nov 24; 59: 45-50.

Oral aphthae. Study of the therapeutic action of Pyralvex on these lesions.

Meillaud-Boffard ML.

Clinical work that demonstrates the effectiveness of Pyralvex in reducing the extent of lesions in the oral cavity, up to guaranteeing complete remission, in a completely easy and effective way.

PYRALVEX AND GINGIVITIS
SSO Schweiz Monatsschr Zahnheilkd. 1980 Aug; 90: 718-24.

[Gingivitis-and plaque-inhibiting action of Pyralvex Berna and its components].

Renggli H.

Interesting study that evaluated the ability of Pyralvex to inhibit plaque formation, thus reducing the subsequent risk of gingivitis.

Method of use and dosage

PYRALVEX®
Topical solution of 0.5 g of rhubarb glucosidic extract and 0.1 g of salicylic acid per 100 ml of solution.
The therapeutic protocol provides for the application of 3-4 brush strokes per day on the region of the oral mucosa affected by the inflammatory process.

Warnings PYRALVEX ® Salicylic acid + glucosidic extract of rhubarb

Prolonged use of PYRALVEX® could lead to the onset of local sensitization reactions, sometimes severe enough to require discontinuation of therapy.
If the lesions do not improve following the application of PYRALVEX®, it would be advisable to consult your doctor and arrange for an adjustment of the current therapy.
It is always important to consider that sometimes lesions of the oral mucosa can be the first signs of clinically relevant systemic pathologies.
It is recommended to avoid ingestion of the drug and contact with eyes.

PREGNANCY AND BREASTFEEDING

The topical use of the product, the absence of a noteworthy systemic absorption of its active ingredients and the lack of studies capable of characterizing the safety profile of the drug for fetal health, make the potential effects of PYRALVEX® unpredictable for fetal health.
For this reason its use during pregnancy should be limited exclusively to cases of real need, carried out under the supervision of your doctor.

Interactions

No drug interactions worthy of clinical note are currently known.

Contraindications PYRALVEX ® Salicylic acid + glucosidic extract of rhubarb

The use of PYRALVEX® is contraindicated in patients hypersensitive to the active substance or to one of its excipients.

Undesirable Effects - Side Effects

The use of PYRALVEX® could cause local adverse reactions from hypersensitization with damage to the oral mucosa.
Fortunately, systemic adverse reactions are rarer and therefore more clinically relevant.

Note

PYRALVEX® is a non-prescription drug.

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