NATRILIX ® is an indapamide-based drug
THERAPEUTIC GROUP: Diuretics / Diuretics with minor diuretic action, thiazide-like.
Indications NATRILIX ® Indapamide
NATRILIX ® is indicated in the treatment of essential hypertension.
Mechanism of action NATRILIX ® Indapamide
NATRILIX ® taken orally, is effectively absorbed from the gastrointestinal tract, reaching maximum plasma concentration within the first hour after administration. The antihypertensive action of NATRILIX ® is due to the presence of the active ingredient indapamide, capable of inhibiting the reabsorption of sodium at the level of the distal tubular epithelium of the nephron, facilitating its urinary secretion and consequently also stimulating an increase in diuresis. to the diuretic action, in the control of hypertension, a second mechanism also seems involved, which allows to control peripheral vascular resistance and to reduce the contraction of the vascular muscles. This effect seems to be mediated by the "increased synthesis of prostaglandins, by the" action vasodilator and anti-aggregating agent.
After its effect, indapamide is excreted - largely intact - mainly through the urine.
Studies carried out and clinical efficacy
1. COMBINED THERAPY WITH INDAPAMIDE IN HYPERTENSION
J Hypertens Suppl. 2008 Jun; 26: S11-5.
Blood pressure lowering with fixed combination perindopril-indapamide: key findings from ADVANCE.
Chalmers J, Joshi R, Kengne AP, MacMahon S.
It is known that the main therapeutic indication of indapamide is essential hypertension. guaranteed a significant improvement in blood pressure (dropped by about 6 mmHg), with a reduction in vascular, renal and cardiac events greater than 14%. Another positive aspect of the combined therapy was the absence of clinically important side effects, despite the fact that they were patients with type II diabetes, for whom hypertensive therapies are often accompanied by an "alteration of the normal glycemic profile.
2. INDAPAMIDE AND IMPROVEMENT OF SEXUAL LIFE
Kardiology. 2009; 49: 44-50.
[Effect of arterial hypertension on sexual health of men and their quality of life. Resuts of BOLERO study]
Saĭgitov RT, Glezer MG.
About 2/3 of patients with hypertension experience a progressive worsening of their sex life. This study, known as BOLERO, showed that the administration of indapamide for 8 weeks ensured a non-worsening of sexual life in about 33% of treated patients, and in only 1% even an improvement. It is known, however, as a improving effect on sexual life, can also be obtained by restoring a correct lifestyle.
3. INDAPAMIDE IN THE CONTROL OF VASCULAR FUNCTIONALITY
Am J Hypertens. 2010 Oct; 23: 1136-43. Epub 2010 May 27.
Effects of blood pressure control with perindopril / indapamide on the microcirculation in hypertensive patients.
Debbabi H, Bonnin P, Levy BI.
The combined treatment with indapamide / perindopril has long been used in patients with hypertension, with excellent results. Hypertension, however, subjects the vascular structures to continuous damage, which can compromise the normal functionality of the microcirculation. This therapeutic combination has proved useful, not only in improving blood pressure levels, but also in improving the structural and functional situation of the " vascular endothelium of the microcirculation, exerting a unique action in this therapeutic category.
Method of use and dosage
NATRILIX ® 2.5mg tablets of indapamide: it is recommended to take one tablet orally in the morning.
NATRILIX ® 1.5 mg tablets of prolonged release indapamide: it is recommended to take one tablet every 24 hours, preferably in the morning.
The increase in the dose is not accompanied by an increase in the antihypertensive effect determined by the control of vascular resistance, while there is an increase in the diuretic effect.
The dose should necessarily be adjusted in the elderly, based on age, sex, weight and the pathological condition that presents.
IN ANY CASE, BEFORE TAKING NATRILIX ® Indapamide - YOU NEED THE PRESCRIPTION AND CONTROL OF YOUR DOCTOR.
NATRILIX ® Indapamide warnings
Before starting the intake of NATRILIX ® and during the entire therapeutic plan, it would be necessary to evaluate the haematological picture of sodium, potassium and chloremia. In patients suffering from diabetes, or undergoing hypoglycemic therapy, or with liver or kidney diseases, it would be necessary - in addition to the periodic control of the electrolytic panel - also the monitoring of blood glucose and uricemia.
Checks should be even more frequent in all those patients suffering from liver and kidney diseases, arrhythmias, cardiovascular problems and predisposed to electrolyte imbalances.
The administration of NATRILIX ® has in some cases been associated with cases of hypercalcemia, justified by the biological action of the active ingredient, which therefore suggests the interruption of the therapy before performing the parathyroid function test.
Although there is no direct evidence that the intake of indapamide is associated with reduced driving ability or with the use of machinery, it must be remembered that some of the side effects of this active ingredient and of diuretics in general, could significantly interfere with normal abilities. perceptive and reactive of the patient.
PREGNANCY AND BREASTFEEDING
Studies conducted on laboratory animals have not shown teratogenic effects on the fetus induced by the administration of the drug. Despite these evidences, the use of NATRILIX ® during pregnancy and breastfeeding is not recommended, given the possible intact secretion of the active ingredient through breast milk.
Interactions
NATRILIX ® could potentiate the toxic effects of:
- Digitalis, due to any drug-induced hypokalemia;
- Lithium salts, following a significant reduction in renal clearance.
Furthermore, the hypotensive effect could be enhanced by the concomitant administration of beta-blockers, ACE inhibitors, methyldopa and other hypotensive drugs. For many of these drugs, however, a greater hypokalaemic effect can also be observed.
Contraindications NATRILIX ® Indapamide
Intake of NATRILIX ® should be avoided in case of hypersensitivity to the drug, to the active ingredient or to one of its components, in patients with severe hepatic and renal insufficiency accompanied by anuria, with cerebro-vascular accidents, with pheochromocytoma and Conn syndrome .
Undesirable Effects - Side Effects
The administration of therapeutic doses of NATRILIX ® may be accompanied by the episodic onset of minor side effects, generally due to the "biological" effect of the drug. The most common occur as a consequence of hypokalaemia, and include dry mouth, fatigue, loss of appetite, muscle cramps, nausea and gastrointestinal problems. The hypotensive effect, on the other hand, could cause dizziness, drowsiness and difficulty in maintaining the position. orthostatic.
This symptomatology becomes decidedly more severe in case of overdose, where it could even progress to respiratory depression.
In case of hypersensitivity to one of the components of NATRILIX ® and the most frequent reactions are dermatological and include hives, eczema and skin rashes.
Note
NATRILIX ® tablets can only be sold under medical prescription.
The use of NATRILIX ® tablets should always be done after consulting your doctor.
The indiscriminate use of NATRILIX ® among athletes and non-athletes, to search for the loss of a few kilos, exposes the body to serious side effects. Furthermore, it is always advisable to reiterate that weight loss is dictated by the elimination of liquids and salts and not by a real slimming effect, intended as a loss of fat mass.
Therefore NATRILIX ® is classified among the DOPING substances.
The information on NATRILIX ® Indapamide published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.
