Medicines to Treat Proctitis

Definition

Proctitis is defined as an acute or chronic inflammatory process affecting the rectum and the moss covering it.

Causes

Multiple and numerous possible etiological factors responsible for proctitis: drug abuse (laxatives / antidiarrheals, antibiotics), ulcerative colitis, bacterial infections (salmonella, shigella), sexually transmitted diseases (eg gonorrhea, chlamydia, genital herpes), Crohn's disease , unprotected sexual intercourse, radiation therapy, food poisoning and trauma.

Symptoms

Typical symptoms associated with proctitis are: rectal pain, minor rectal bleeding, frequent need to defecate, and anal discharge of mucus or pus. In addition, the patient with proctitis often complains of diarrhea, dehydration, fever, anal itching and rectal tenesmus.

Diet and Nutrition

The information on Proctitis - Proctitis Treatment Drugs is not intended to replace the direct relationship between health professional and patient. Always consult your doctor and / or specialist before taking Proctitis - Proctitis Treatment Medications.

Medicines

Given the numerous triggering causes of proctitis, the drug must be chosen exclusively on an etiological basis; strictly speaking, it would be unintelligent to start a therapy regardless of the identification of the cause. To give a practical example, it would be useless to take antibiotics when proctitis is a consequence of genital herpes.

The following are the classes of drugs most used in therapy and some examples of pharmacological specialties: it is up to the doctor to choose the active ingredient and dosage most suitable for the patient, based on the triggering cause, the severity of the disease, and the response of the patient. sick to the cure:

Anti-inflammatory drugs (NSAIDs and corticosteroids): to be taken only in case of proctitis of an inflammatory nature. Generally, topical (rectal) therapy is recommended, but when the patient is unable to hold liquid enemas, it is preferable to opt for systemic (oral) treatment. In case of seriousness, it is possible to subject the patient to intravenous therapy.

MESALAZINE (or 5-aminosalicylic acid) (eg. ASACOL, CLAVERSAL, Asalex, Enteraproct, Mesaflor): this drug is useful for all inflammatory forms affecting the intestine, both for the remission of symptoms and for the prevention of relapses . For the treatment of proctitis, topical-rectal administration of 500 mg suppositories is recommended: 1 suppository three times a day. In the form of a rectal solution, topical application of 2 grams of drug twice a day (morning) is recommended. and evening before bedtime), or 4 grams once a day (before bedtime). The duration of treatment must be established by the attending physician. Oral administration of mesalazine in tablets is also possible: take 2-4 g of active ingredient per day, in divided doses, as prescribed by the doctor.
Balsalazide (eg Balzide): in case of ulcerative colitis proctitis, oral administration of 2.25 g of the drug three times a day for 8-12 weeks is recommended. Useful to avoid the degeneration of proctitis into ulcerative megacolon.
Olsalazine (eg Dipentum) also this drug, like the previous one, is used in therapy for the treatment of proctitis associated with ulcerative colitis. Take 500 mg to 1 gram of the drug per day, divided into two doses. Alternatively, take 4 doses of 500mg per day when dealing with a severe form. Although the duration of therapy must be established by the doctor, in most cases, it does not last beyond 7 days.
Sulfasalazine (eg Salazopyrin EN) is a drug combined with 5-aminosalicylic acid (5-ASA) and sulfapyridine, effective for the treatment of ulcerative colitis proctitis. Take rectally (suppositories) 0.5-1 g of drug in the morning and in the evening after evacuation. The active ingredient is also available in the form of enemas, to be administered 3 g in the evening before going to bed: retain the active ingredient for at least an hour. Alternatively, take 1-2 g of drug orally, repeating the operation up to 4 times a day.
Hydrocortisone (eg. Locoidon, Colifoam): the drug, belonging to the class of corticosteroids, should be taken at a dosage of 100 mg (rectal suspension) in the evening for 21 days or for a remission of symptoms to occur. In severe cases, therapy can be continued for 2 or 3 months. When the treatment does not give results within 2-3 weeks, stop taking the drug. When the therapy lasts more than 21 days, slowly decrease the dosage before stopping the treatment. Consult your doctor.
Budesonide (eg Biben, Pulmaxan): indicated in particular for the treatment of proctitis associated with Crohn's disease. Take 3 mg of active ingredient orally, 3 times a day for 8 weeks. In the last two weeks of treatment, it is recommended to gradually reduce the dose before stopping taking the drug. The active ingredient is also recommended in case of proctitis from ulcerative colitis affecting the rectum: in this case, application is recommended. rectal of an enema in the evening before bed, for a period of 4 weeks.

Antibiotics: Administration of antibiotics is not indicated for all forms of proctitis. Exclusively in case of bacterial infections associated with proctitis, it is recommended to take antibacterial-antibiotic drugs. Here are some examples:

METRONIDAZOLE (eg Flagyl, Metronidazole Same, Rozex): indicated for Crohn's disease proctitis and trichomoniasis. In the first case, oral administration of 250 mg of the drug every 6 hours is recommended; in the second, however, the recommended dose is 2 g once a day (or 500 mg twice a day, depending on the severity of the disease) for a period of 7 days; alternatively, take 375 mg of active ingredient twice a day for 7 days.
Doxycycline (eg Doxycicl, Bassado): this antibiotic, belonging to the tetracycline class, is useful in case of proctitis caused by sexually transmitted diseases. It is recommended to administer the drug at a dosage of 100 mg once a day, preferably associated with ceftriaxone (eg Ceftriaxone, Pantoxon, Ragex, Deixim), belonging to the class of quinolones.

N.B. in case of proctitis, it is advisable to follow a balanced diet, free of excesses, excluding spicy and spicy foods, responsible for a possible aggravation of the symptomatological picture.