FENISTIL (gel) ® Dimethindene

FENISTIL ® is a drug based on Dimethindene maleate

THERAPEUTIC GROUP: Antipruritic including antihistamines, anesthetics etc.

Indications FENISTIL (gel) ® Dimethindene

FENISTIL ® is indicated in the treatment of itchy skin forms, sunburn and insect bites.

Mechanism of action FENISTIL (gel) ® Dimethindene

Dimetindene, active principle of FENISTIL ®, is a drug belonging to the vast category of histamine antagonists of H1 receptors, therefore endowed with a conspicuous antipruritic, anti-edematous and anti-inflammatory power.
By antagonizing the effects of histamine, Dimetindene in addition to inducing the aforementioned effects is also able to exert a modest local analgesic action, important in relieving pain generally associated with irritative and itchy skin manifestations.
The aforementioned activities are supported by advantageous pharmacokinetic properties which by limiting the systemic absorption of Dimethindene, following its topical application, control the incidence of the classic side effects associated with systemic therapy with antihistamines, including mainly those affecting the central nervous system.

Studies carried out and clinical efficacy

ADVERSE REACTIONS TO DIMETINDENE
Contact Dermatitis. 2011 Mar; 64: 170-1. doi: 10.1111 / j.1600-0536.2010.01830.x.

Contact dermatitis and secondary systemic allergy to dimethindene maleate.

Leroy A, Baeck M, Tennstedt D.

Case report denouncing the appearance of clinically relevant side effects following the topical use of Dimetindene maleate such as contact dermatitis and systemic allergy, so serious as to require hospitalization.

THE EFFECTIVENESS OF DIMETINDENE IN THE TREATMENT OF RHINITIS
Rhinology. 2003 Sep; 41: 159-66.

Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis.

Kirchhoff CH, Kremer B, Haaf-von Below S, Kyrein HJ, Mösges R.

Clinical trial demonstrating the efficacy of Dimetindene applied topically through nasal spray in improving the quality of life of patients suffering from seasonal allergic rhinitis.

DIMETINDENE IN THE TREATMENT OF BURNS
Arzneimittelforschung. 1999 Apr; 49: 374-9.

Dimethindene maleate in the treatment of sunburn. A double-blind, placebo-controlled pilot study.

Schaffler K, Beckers C, Unkauf M, Kyrein HJ.

This study demonstrates the clinical efficacy of Dimetindene in the treatment of sun burns, thus ensuring an improvement in both the symptoms and the inflammatory state of the skin and injured tissues.

Method of use and dosage

FENISTIL ®
Gel for cutaneous use with 0.1% Dimethindene maleate
Depending on the intensity of the inflammatory process in progress and the symptoms complained of, it is generally recommended to apply the appropriate amount of gel 2-3 times a day on the affected region, massaging it gently in order to favor its absorption.

Warnings FENISTIL (gel) ® Dimethindene

Therapy with FENISTIL ® should be preceded by a careful medical examination aimed at clarifying the origin of the complained symptoms and the relative prescribing appropriateness.
In order to optimize the therapeutic efficacy, reducing the potential side effects, it would be advisable for the patient to comply with some sanitary standards such as:

• thoroughly cleanse your hands after applying the drug;
• avoid contact of the drug with exposed eyes and mucous membranes;
• avoid the application of the drug on extensive and secreting skin lesions;
• avoid direct exposure to solar radiation;
• comply with medical indications;
• consult your doctor if unwanted effects appear.

It is also recommended to store the drug out of the reach of children.

PREGNANCY AND BREASTFEEDING

The use of FENISTIL ® during pregnancy and in the subsequent period of breastfeeding should only be carried out in cases of real need and always under the strict supervision of your doctor.

Interactions

No clinically relevant drug interactions are currently known.

Contraindications FENISTIL (gel) ® Dimethindene

The use of FENISTIL ® is contraindicated in patients with hypersensitivity to the active principle or to one of its excipients, or with particularly conspicuous and secreting skin affections.

Undesirable Effects - Side Effects

The use of FENISTIL ®, especially when prolonged for a long time, could cause the appearance of local adverse reactions such as redness, burning, dryness and exacerbation of symptoms.

Note

FENISTIL ® is a drug not subject to mandatory medical prescription.

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