DIFFERIN ® is a drug based on Adapalene
THERAPEUTIC GROUP: Anti-acne preparations for topical use
Indications DIFFERIN ® Adapalene
DIFFERIN® is indicated in the treatment of vulgar acne in all its manifestations.
Mechanism of action DIFFERIN ® Adapalene
DIFFERIN ® is a medicinal product based on Adapalene, a third generation retinoid widely used in the treatment of acne.
The comedolotic and keratolytic activity is due to the ability to selectively bind the nuclear retinoic acid receptor, modulating gene expression in an anti-inflammatory and antiproliferative sense.
The anti-inflammatory stimulus on the one hand and the control of the proliferation of keratinocytes on the other allow an effective control of the inflammatory evolution of the skin lesion, thus allowing a clear improvement in the quality of the skin and normalizing the production of keratin so as to limit the " hyperkeratinization typical of acne pathology.
The aforementioned mechanisms, also supported by the control of inflammatory chemotaxis, are supported by the good pharmacokinetic properties that reduce the absorption of topically applied Adapalene to a minimum, thus reducing the potential systemic side effects.
Studies carried out and clinical efficacy
TOLERABILITY AND EFFECTIVENESS OF ADAPALENE
J Cosmet Dermatol. 2013 Jun; 12: 103-7. doi: 10.1111 / jocd.12031.
Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single-center, randomized, double-blinded, placebo-controlled clinical trial on Mexican patients (skin type III-IV).
Tirado-Sánchez A, Espíndola YS, Ponce-Olivera RM, Bonifaz A.
Interesting study that demonstrates how the treatment of acne with Adapalene or Trethionine produces the same therapeutic effect, although the first active principle is better tolerated than Trethionine in Mexican patients.
"SEBOSTATIC ACTIVITY OF ADAPALENE"
J Dermatol Sci. 2013 Jun; 70: 204-10. doi: 10.1016 / j.jdermsci.2013.02.003. Epub 2013 Feb 14.
Adapalene suppresses sebum accumulation via the inhibition of triacylglycerol biosynthesis and perilipin expression in differentiated hamster sebocytes in vitro.
Sato T, Akimoto N, Kitamura K, Kurihara H, Hayashi N, Ito A.
Experimental study that demonstrates how Adapalene can contribute to the improvement of acne lesions, also ensuring better control over sebum production, probably through the control of local triglyceride synthesis
ADAPALENE vs BENZOYL PEROXIDE / CLINDAMYCIN
J Drugs Dermatol. 2012 Jun; 11: 714-22.
Effects of benzoyl peroxide 5% clindamycin combination gel versus adapalene 0.1% on quality of life in patients with mild to moderate acne vulgaris: a randomized single-blind study.
Guerra-Tapia A.
Study that demonstrates how the combination of Benzoyl peroxide and Clindamycin can guarantee a faster improvement in the quality of life of patients suffering from acne than Adapalene, despite the fact that safety and tolerability are similar.
Method of use and dosage
DIFFERIN ®
Adapalene 0.1% gel and cream for topical use
Generally it is recommended to apply the appropriate amount of cream or gel directly on the affected area, after cleansing it, once a day, taking care to gently massage the area until it is completely absorbed.
Warnings DIFFERIN ® Adapalene
In order to optimize the therapeutic efficacy, reducing the potential side effects of the therapy, it would be advisable:
- avoid direct contact with eyes and mucous membranes;
- thoroughly cleanse your hands after applying the drug;
- avoid exposure of the treated region to sunlight;
- avoid applying the medicine to damaged skin or skin affected by other pathologies.
It is recommended to store the drug in a cool, dry place out of the reach of children.
PREGNANCY AND BREASTFEEDING
Given the absence of studies able to best characterize the safety profile of Adapalene for the health of the fetus and infant, it is advisable to extend the contraindications to the use of DIFFERIN ® also to pregnancy and the subsequent lactation period. otherwise.
Interactions
The patient receiving DIFFERIN ® should avoid the topical application of other drugs.
Contraindications DIFFERIN ® Adapalene
The use of DIFFERIN ® is contraindicated in patients hypersensitive to the active substance or to one of its excipients.
Undesirable Effects - Side Effects
Adapalene therapy could lead to local and transient side effects such as burning, irritation, itching and dry skin.
Fortunately, clinically relevant side effects are rarer.
Note
DIFFERIN ® is a drug subject to mandatory medical prescription.
The information on DIFFERIN ® Adapalene published on this page may be out of date or incomplete. For a correct use of this information, see the Disclaimer and useful information page.
