Calabar bean: Property of the Calabar bean

Scientific name

Physostigma venenosum

Family

Leguminosae

Origin

West Africa

Synonyms

Calabar bean

Parts Used

The drug consists of the black seeds

Chemical constituents

• Indole alkaloids with specific action on the nerve endings of the parasympathetic: hexerine or physostigmine, which act as antagonists of atropine.

Calabar bean: Property of the Calabar bean

In medicine, only the single active ingredients are used in medicine, essentially in ophthalmology (as a miotic in the treatment of glaucoma) and in surgery to stimulate the recovery of intestinal motility.

Contraindications

Avoid use in case of ascertained hypersensitivity to one or more components of the calabar bean.

Pharmacological interactions

• receptor interactions with anticholinergics, atropine and atropine-like, antiparkinsonian, antispasmodic, neuroleptic and phenotiacin drugs.

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