and creatinine (PCR - protein / creatinine ratio) and albumin and creatinine (ACR - albumin / creatinine ratio) is respectively used in the diagnosis of proteinuria and microalbuminuria. Males (mg / mMol) Females (mg / mMol) Normoalbuminuiria <2,5 <3,5 Microalbuminuria 2,5-25 3,5-35 Macroalbuminuria >25 >35
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This test partially replaces the traditional test based on the quantification of proteins in a urine sample collected over 24 hours, which sets the maximum normal limit at 150 mg of total protein in the urine; higher protein concentrations are considered a warning signal. proteinuria.
As anticipated, in place of this test, it is possible to use the study of the proteinuria / creatininuria or albuminuria / creatininuria ratio on a random urine sample, preferably in the morning. Based on the values of these indices, doctors speak of mciroalbuminuria and proteinuria, respectively.
(albuminuria / creatininuria) is between 3.5 mg / mmol and 35 mg / mmol in women and between 2.5 mg / mmol and 25 mg / mmol in males. The difference between male and female is linked to the fact that men - by virtue of the greater muscle mass - have higher urinary concentrations of creatinine. Other authors consider positive ratios between 30-300 μg / mg, which correspond to values of 3.5-35 mg / mmol for both sexes.
Above these values we speak of macroalbuminuria.
(proteinuria / creatininuria) is equal to or greater than 45 mg / mmol (which is equivalent to an albuminuria / creatininuria ratio greater than 30 mg / mmol). Values below 2 mg / mmol are considered normal, while values above but below 45-50 mg / mmol are worthy of diagnostic investigations and adequate therapeutic interventions, especially in people with risk factors such as diabetes or hypertension (a better glycemic and blood pressure control and - given the increased cardiovascular risk - lipidemic).
