Apolipoprotein A1

Generality

Apoliprotein A-1 (Apo A-1) is the main component of high-density lipoproteins (or HDL), ie the so-called “good” cholesterol.

HDL removes excess cholesterol from cells and transports them to the liver for recycling or disposal.

Apoliprotein A-1 plays a specific role in lipid metabolism:

• Allows the transport of cholesterol and triglycerides into the bloodstream;
• It allows HDL to recognize specific receptors present on the membranes of some cells, in order to bind to them.

Apoliprotein A-1 is usually measured together with Apo B (the main protein structural component of LDL, ie low density lipoproteins), to better understand the ratio between HDL and LDL cholesterol.
Apo A-1 values ​​tend to increase and decrease along with HDL concentrations; therefore, Apo A-1 deficiency correlates with an increased risk of developing cardiovascular disease (CVD).

What's this

Apolipoprotein A-1, also known as APO1 or Apo A-1, is a human gene that codes for the homonymous protein, the main protein component of high-density lipoproteins (HDL, the so-called "good" cholesterol).