Related topics: estrogen; soy; soy isoflavones
Most phytoestrogens are taken with the diet in the form of inactive glycosidic compounds (complexed with sugar molecules), which are then hydrolyzed by the intestinal flora. By the action of these microorganisms, food phytoestrogens are converted into active substances, which are partly absorbed and partly further metabolized.
The absorption of phytoestrogens varies, therefore, from subject to subject and numerous conditions can limit, in a negative sense, their metabolism. sugars and fibers), surgical interventions and pathologies of the digestive tract (cholelithiasis, colitis, constipation, etc.).
Equol, for example, is the isoflavonic metabolite with the greatest antioxidant activity. It derives from the action of the intestinal microflora on daidzein and in the course of various studies it has been seen that this conversion occurs only in 35-70% of the population (important , therefore, the possible integration with probiotics and prebiotics). This consideration, moreover, could be the basis of the different individual responses observed during the clinical studies conducted to investigate the therapeutic efficacy of phytoestrogens.For the same reason, the evaluation of their biological and phytotherapeutic activity should take place on the basis of the blood or urinary concentration of the respective metabolites, rather than on the simple dietary intake.
How to use
in the course of the various clinical studies, dosages of phytoestrogens varying between 34 and 160 mg / day were used. The ideal daily intake has been estimated at 40-60 mg. The achievement of this threshold is ensured by the simple consumption of foods rich in phytoestrogens, such as soy, legumes in general and whole foods. The consumption of these foods, included in the context of a sober diet, which prevents insulin resistance (consumption of foods with a low glycemic load), it represents, in all probability, the best weapon to prevent estrogen-dependent tumors.
Isoflavones (tot.)
(mg / 100 g) *
mg per average serving
equivalent to (g)
(*) The content of phytoestrogens and their quality varies greatly in relation to the place of cultivation, the climate, the characteristics of the soil and the methods of harvesting, extraction and conservation.
Side effects
There are no known serious side effects of phytoestrogens in men. As a precaution it is not recommended to use them during pregnancy (they could induce alterations in the development of the male reproductive system) and in association with hormonal therapies.
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