Generality
Hesperidin is one of the characteristic flavonoids of citrus fruits, where it is concentrated above all in the peel and in the albedo (the whitish inner part of the peel).
Present to a lesser extent also in green leafy vegetables, hesperidin is made up of a sugar part, the disaccharide rutinose, linked to the flavone hesperitin.
Hesperidin is used as such in the pharmaceutical field; we find it for example in DAFLON ®, indicated as an adjuvant therapy in the treatment of varicose veins, phlebitic complications of hemorrhoids and those related to states of capillary fragility.
In fact, hesperidin is widely known for its capillarotropic effects: it reduces the permeability and fragility of the capillary walls, while increasing their resistance; in this sense, it shares the action of other plant substances, such as diosmin, aescin, rutin, extracts of horse chestnut, red vine, sweet clover, centella asiatica and blueberries.
At the same time, hesperidin boasts remarkable antioxidant and anti-inflammatory properties, while in preliminary studies on mouse models it has shown hypotensive, hypocholesterolemic and, in large doses, osteotrophic properties (see the "Hesperidin" article for the reference bibliography).
Indications
Why is hesperidin used? What is it used for?
All "hesperidin, as well as other flavonoids, are attributed above all antioxidant activities.
From the various evidences, in fact, expiridine would seem to exert a marked antioxidant activity, acting as a direct scavenger against oxygen and nitrogen free radicals, and inducing the synthesis of new antioxidants.
According to various authors, hesperidin could also play an important role in the management of inflammatory, allergic and dyslipidemic states.
Properties and Effectiveness
What benefit has hesperidin shown during the studies?
The number of studies related to the clinical efficacy of hesperidin has grown exponentially in recent years.
Although most of these studies are experimental in nature, the results appear quite captivating and worthy of further study.
Hesperidin and metabolisms
Beyond the classic antioxidant activity, recent studies, both of an experimental and clinical nature, have shown how the regular consumption of hesperidin is effective, in just 4 weeks, in determining a marked improvement in cholesterolemia, with an increase in HDL cholesterol concentrations at the expense of atherogenic fraction LDL.
This activity, together with the vasoprotective function, could be useful in the prevention of endothelial dysfunction and at the same time in the reduction of cardiovascular risk.
Hesperidin and vascular function
The antioxidant activity on the one hand and the anti-inflammatory action on the other would make hesperidin an excellent ally for vascular health.
To support the vasoprotective benefits of hesperidin there are also numerous evidences, both of an experimental and clinical nature, according to which the use of this antioxidant could significantly improve the symptoms of hemorrhoids or vascular dysfunction.
Hesperidin and cancer
Although still in a very embryonic stage, some evidence would undermine the antitumor activity of hesperidin.
More precisely, hesperidin seems to exert an antimutagenic and immunomodulating action, particularly valuable in the course of esophageal carcinoma, colorectal cancer and melanoma.
Further developments are awaited in this regard.
Dosage and method of use
How to use hesperidin
Hesperidin is present in several supplements, both as a single supplement and as a blend of antioxidants.
The most commonly used dosage in studies is 500 mg per day.
In the management of venous insufficiency and haemorrhoidal pathology, hesperidin is often associated with diosmin, in a product with a complete formulation and a strong antioxidant and vasoprotective activity.
Side effects
The use of hesperidin is generally well tolerated and free from clinically significant side effects.
To date, the most frequently observed adverse reactions are those of a gastrointestinal nature, with the onset of nausea and abdominal cramps.
Contraindications
When should expiridine not be used?
The use of hesperidin is contraindicated in case of hypersensitivity to the active principle.
Pharmacological interactions
What drugs or foods can modify the effect of hesperidin?
The pharmacokinetic characteristics of hesperidin and other flavonoids are not yet fully known.
In particular, according to some evidences, the use of hesperidin seems to improve the absorption and activity of vitamin C, while other authors describe a contrary action.
Precautions for use
What do you need to know before taking hesperidin?
The use of hesperidin supplements during pregnancy and in the subsequent breastfeeding period should be supervised by your physician.
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