About Red Stack - Ke Forma
RED STACK- KE SHAPE
Food supplement based on natural dry extracts.
FORMAT
Jar of 90 capsules
COMPOSITION
Citrus aurantium peel dry extract (synephrine 6%); Ginger dry extract (5% gingerols); Caffeine; Chilli pepper powdered; Willow bark (salicin 15%); Theobromine; Phenylalanine; Tyrosine; Taurine; Potassium of iodide; Anti-caking agent: silicon dioxide. Wrapping: food gelatin
Product features Red Stack - Ke Forma
Thermogenesis: the maintenance of body temperature is of vital importance for the human organism, which undertakes to keep it constant both through a series of easily observable mechanisms and through the activation of deep and unconscious processes. Among the most immediate and rapid adjustment methods we mention:
thermogenesis with shiver, characterized by an asynchronous contraction of agonist and antagonist muscles, necessary to increase the production of heat up to 3 times compared to the basal condition;
peripheral vasoconstriction and central vasodilation, necessary to keep vital organs metabolically active.
Alongside the thrill, there is a series of other biochemical processes underlying the activation of the sympathetic system and belonging to the so-called thrill-free thermogenesis; these mechanisms guarantee the production of heat through the breaking of chemical bonds and through the conversion of chemical energy into energy All these biochemical events are active processes, which require a significant energy expenditure that inevitably affects the daily energy requirement. It is no coincidence that thermogenesis is also used as a method of weight control by the body, which can thus maintain its weight even when subjected to high-calorie diets (provided that these processes are particularly active).
If the various foods contribute to this energy expenditure, affecting the forced thermogenesis induced by the diet - that is, the caloric expenditure necessary to digest, absorb and metabolize a certain nutrient - the specific supplements determine the induction of an optional thermogenesis, guaranteed by the presence of specific substances capable of modulating the sympathetic nervous response and acting specifically on certain tissues.
Among the most active tissues in this sense we find the omnipresent liver (central organ in human metabolism), muscle tissue and adipose tissue. In particular, a specific variant of this tissue - known as brown adipose tissue, present in high quantities during the fetal life and concentrated only in small foci in the adult human organism - it is highly involved in the genesis of heat, thanks to the presence of uncoupling proteins that allow to dissipate the mitochondrial proton gradient in thermal energy, without the production of ATP.
Thermogenesis and weight loss
From the brief presentation carried out, it is clear how thermogenesis can be useful in controlling body weight, and how inevitably body weight can influence the thermogenic capacity of the organism. In particular, during a weight loss process supported by low-calorie diets, it is inevitably found a reduction in the body's thermogenic capacity, which affects the continuation of weight loss. And this is precisely one of the still open discussion points, on which to work in order to make weight loss gradual, not stressful and lasting.
Thermogenesis and thermogenics
Thermogenic supplements are therefore born with the aim of supporting the organism in thermogenesis, acting mainly at the level of optional thermogenesis and acting as sympathetic mimetics and receptor modulators.
Product composition in brief:
Red Stack - Ke Forma
Dry extract of bitter orange 490 mg, of which synephrine 30 mg: plant from Southeast Asia rich in flavonoic glucosides, coumarin, aldehydes and monoterpenes. Among the most biologically active principles we remember synephrine and octopamine. Their effects are realized in a:
- Sympathetic mimetic action: they are able to activate alpha 1 adrenergic receptors and induce peripheral vasoconstriction;
- Thermogenic action: first experimental evidences show the ability of these principles to act on beta 3 receptors.
Various disorders are associated with the intake of synephrine, from tremors to headaches, from tachycardia to hypertension, up to arrhythmias and cardiac arrest; however, the potentially dangerous quantities are not known.
Ginger 60 mg, of which gingerols 3 mg: the main effects of this plant are due to the presence of gingerols (contained in the dry ginger extracts). It is believed that these products can exert an antiemetic, anti-inflammatory, hepatoprotective and thermogenic action. In particular, it is believed that they can act by stimulating thermoregulatory receptors, inhibiting serotonin-induced hypothermia and stimulating the secretion of cytokines with a pyrogenic effect.
Willow 100 mg, of which salicin 15 mg: bark rich in salicylates, flavonoids and essential oil. Among the salicylates, the most abundant is salicin, known for its anti-inflammatory, antipyretic and pain-relieving properties, and for the absence of the classic side effects of acetylsalicylic acid (gastric mucosal irritation and increased blood fluidity). Particular attention should be paid to individuals allergic to salicylates.
Caffeine 200 mg: methylxanthine commonly introduced through coffee; an espresso can in fact contain up to 100mg. After taking, the caffeine is rapidly circulated and used by the various tissues. It therefore acts at different levels, on the stomach, favoring acid secretion, on the heart, increasing its frequency and contractile intensity, on the respiratory system, improving the ventilatory capacity, on muscle tissue, improving its contraction, and on the nervous system, increasing the secretion of catecholamines with consequent activation of the sympathetic system, which is important for supporting thermogenesis. The maximum safe dose used in the studies is 300 mg, beyond which they record tremors, anxiety, tachycardia, insomnia and excitement. Prolonged use, on the other hand, represents an important risk factor for pathologies of the gastrointestinal, cardiovascular and nervous tract (migraine).
Theobromine 100 mg: alkaloid extracted from the cocoa tree. It belongs to the xanthine family and as such has the same effects as caffeine, albeit more modest. The lethal doses of this alkaloid are around 330 mg per kg, but even at lower doses it can cause tremor, restlessness, nausea and anxiety.
L- Tyrosine 100 mg: polar amino acid not essential for humans. It is part of the synthesis of some hormones, such as thyroxine and catecholamines. The positive effect on the hormonal profile - which is found with an increase in the blood levels of these hormones - it seems to have a positive effect on both the psychic and physical spheres. The daily requirement is between 500 and 1500 mg, but an excessive intake could interfere with normal hormonal secretion.
Chilli fruit powder 50mcg: important for the presence of capsaicin, responsible for the immediate burning sensation and subsequent relief that follows its intake. The pain stress induced by this alkaloid causes a release of catecholamines and an enhancement of the sympathetic response. However, capsaicin is also known for its anti-inflammatory and pain-relieving properties.
L-Taurine 100 mg: conditionally essential amino acid, produced starting from sulfur amino acids such as methionine and cysteine, particularly concentrated in the skeletal and cardiac muscle, and in the brain. It is part of numerous biological functions, such as the protection of oxidative damage, and the modulation of the immune response; moreover, it seems to assist caffeine in its stimulating action.
In sports, taurine has been used successfully in the reduction of oxidative damage induced by intense physical activity, effectively protecting the muscular structures, already at doses of 1.5 g / day.
L-phenylalanine 200 mg: non-polar amino acid essential for the human body. It too, as a precursor of tyrosine, can actively participate in the synthesis of catecholamines and dopamine, improving cognitive abilities. It also appears to be involved in regulating the hunger / satiety cycle, reducing appetite.
Iodine 150 mcg: quantity necessary to meet the daily energy requirements. Iodine is part of the synthesis of thyroid hormones, involved in numerous biological reactions; Iodine deficiencies are quite frequent in some areas of the planet, and manifest themselves with mental disorders, goiter, hypothyroidism and growth retardation. Excessive doses are responsible for acute symptoms, characterized by heartburn, nausea, vomiting, diarrhea and coma, and a chronic one, characterized by hyperthyroidism and higher incidence of thyroid carcinomas. These symptoms would manifest themselves for dosages higher than 1.1 mg / day (1100 mcg).
Rationale for integrating Red Stack - Ke Forma into sports practice
Although the literature concerning the individual compounds of the Red Stack - Ke Forma product is particularly rich, it lacks an "as much scientific richness as regards thermogenics in commercial formulation.
From the few articles present, however, it appears evident a real effectiveness of these products in increasing the daily energy requirement up to 20%. This ability, in a low-calorie diet and planned physical activity, could have a positive effect on weight reduction. In fact, it is essential to clarify that the thermogenic ALONE IS NOT ABLE TO GUARANTEE A SLIMMING EFFECT, and that this can only be achieved in the context of a well-calibrated dietary plan.
Furthermore, it would be appropriate to reiterate that thermogenic IS NOT synonymous with fat burning, given the various literature that demonstrates how these products do not shift the metabolism towards the lipid one, but only create a greater calorie expenditure.
Method of use recommended by the company - Red Stack - Ke Forma
We recommend taking two capsules a day, possibly before meals
Red Stack Side Effects - Ke Forma
The presence of alkaloids and active ingredients capable of interfering with the hepatic enzyme chain, responsible for drug metabolism, could decisively alter the pharmacokinetic properties of certain active ingredients, enhancing or reducing their effects.
In the literature there is no specific indication about potential side effects associated with the administration of the product in question, therefore these should be traced back to the side effects of the individual components.
Precautions for use Red Stack - Ke Forma
The Red Stack - Ke Forma product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, pregnancy, breastfeeding and under 12 years of age, as well as in adolescents not yet trained.
The Red Stack - Ke Forma product must be used as part of an adequate low-calorie diet, following a healthy lifestyle with a good level of physical activity. If the diet is followed for prolonged periods of more than 3 weeks, it is advisable to seek medical advice.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about Red Stack's critical analysis - Ke Forma.
Brown Adipose Tissue, Whole-Body Energy Expenditure, and Thermogenesis in Healthy Adult Men.
Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, Saito M.
The role and importance of brown adipose tissue in energy homeostasis.
Cypess AM, Kahn CR.
Curr Opin Pediatr. 2010 May 17. [Epub ahead of print]
Cold thermoregulatory responses following exertional fatigue.
Castellani JW, Sawka MN, DeGroot DW, Young AJ.
Front Biosci (Schol Ed). 2010 Jun 1; 2: 854-65.
Cellular bioenergetics as a target for obesity therapy.
Tseng YH, Cypess AM, Kahn CR.
Nat Rev Drug Discov. 2010 Jun; 9: 465-82. Review.
Adaptive reduction in thermogenesis and resistance to lose fat in obese men.
Tremblay A, Chaput JP.
Br J Nutr. 2009 Aug; 102: 488-92.
Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight.
Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL.
Am J Clin Nutr. 2008 Oct; 88: 906-12.
JD, Lovallo WR. Influence of grapefruit juice on caffeine pharmacokinetics and pharmacodynamics. Pharmacotherapy
16:1046-
Effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin
Pharmacol 35: 431-6.
R. K. Bhardwaj, H. Glaeser, L. Becquemont, U. Klotz, S. K. Gupta, M. F. Fromm.Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.. J. Pharmacol. Exp. Ther. 302: 645-5
www.smartdrug.com
Phytotherapy manuals
Effects of ingesting a commercial thermogenic product on hemodynamic function and energy expenditure at rest in males and females.
Wilborn C, Taylor L, Poole C, Bushey B, Williams L, Foster C, Campbell B.
Appl Physiol Nutr Metab. 2009 Dec; 34: 1073-8.
Acute effects of a thermogenic nutritional supplement on energy expenditure and cardiovascular function at rest, during low-intensity exercise, and recovery from exercise.
Ryan ED, Beck TW, Herda TJ, Smith AE, Walter AA, Stout JR, Cramer JT.
J Strength Cond Res. 2009 May; 23: 807-17.
The acute effects of the thermogenic supplement Meltdown on energy expenditure, fat oxidation, and hemodynamic responses in young, healthy males.
Jitomir J, Nassar E, Culbertson J, Moreillon J, Buford T, Hudson G, Cooke M, Kreider R, Willoughby DS.
J Int Soc Sports Nutr. 2008 Dec 16; 5: 23.
Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects.
Belza A, Frandsen E, Kondrup J.
Int J Obes (Lond). 2007 Jan; 31: 121-30. Epub 2006 Apr 25.
Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation.
Belza A, Jessen AB.
Eur J Clin Nutr. 2005 Jun; 59: 733-41.