Sublingual Melatonin 3 - Jamieson

Information on Melatonin 3 Sublingual - Jamieson

Sublingual Melatonin 3 - Jamieson

Food supplement based on Melatonin in sublingual tablets

FORMAT
Pack of 15/30 plates

COMPOSITION (for one plate): Melatonin 3 mg

Note: the plates are made of pullulan, a colorless and edible polysaccharide extracted from starch. Being soluble in an aqueous environment, it can be easily hydrolyzed and guarantee the release of the active principle directly in the sublingual area.

Product Features Melatonin 3 Sublingual - Jamieson

Sublingual absorption: the sublingual absorption is an alternative route to the classic oral administration and the relative gastric or intestinal absorption. Although the absorption surface is quite small (about 0.02 m2), the high vascularization of the sublingual region guarantees an optimization of this process. The main advantages deriving from this method of administration are expressed in a faster kinetics, and above all in a greater bioavailability.

The possibility of skipping the first pass metabolism, to which melatonin is very sensitive, means that the dose administered sublingually corresponds, in terms of bioavailability, to double the amount taken orally.

Melatonin: derived directly from serotonin and before that from tryptophan, it is synthesized in a gland located at the diencephalic level and known as epiphysis. The synthesis of this hormone is strongly regulated - as well as by the availability of the substrate - by the light / dark ratio. The light stimulus, in fact, received by cells similar to retinal photoceptors, activates a series of biological mechanisms that lead to the total inhibition of the enzyme involved in the synthesis of melatonin. It is therefore understood how the maximum production of this neurohormone is recorded at night, where the light stimulus is minimal. Light, however, is not the only stimulus capable of interfering with the endogenous synthesis of melatonin; in fact, even alcohol, smoking, tranquilizers, caffeine, vitamin B12, ibuprofen, other drugs and aging greatly affect the epiphyseal function. The integration with melatonin, in addition to the hypnotic and sedative effect, it is able to protect the pineal gland, reducing its exhaustion and protecting it from calcification and degeneration.
In addition to the regulation of the biological clock and sleep / wake rhythm, its main application, melatonin also actively participates in other important reactions, such as:

1. Redox reactions: the antioxidant function of melatonin and its metabolites is now known. The high protection it offers against reactive oxygen and nitrogen species place it among the most relevant antioxidant molecules, despite the commitment in this process involves the net loss of the involved share, given the absence of reductase able to regenerate it.
2. Immune reactions: several experimental evidences have correlated the administration of melatonin to a significant strengthening of the immune defenses. More precisely, an improvement in both the non-specific immune defenses (inflammatory reactions) and the adaptive defenses (improvement of the antibody and cytotoxic response) was observed.
3. Protective reactions: melatonin is able to protect the cell, and in particular its DNA, from the action of mutagens. Although there are no valid experiments on men, it has been used in Prof. Di Bella's cocktail for its potential. anticancer actions.
4. Metabolic reactions: although still in the characterization phase, early evidence suggests that the activation of the MT1 receptor for melatonin can improve insulin sensitivity and protect laboratory mice from the onset of type II diabetes.

Despite the multiple capabilities of this molecule, melatonin is currently used in all those disorders and conditions that involve difficulty falling asleep and alterations in the sleep / wake cycle.

Melatonin and physical activity: although there are no direct and particularly important benefits relating to the use of melatonin in sports, some studies show:

1. Improvement of hormonal secretion: in particular it seems that the administration of melatonin can optimize the secretion of GH in athletes subjected to resistance training;
2. Antioxidant effect: together with other antioxidants, melatonin can guarantee greater protection of muscle tissue, and not only, from the oxidative damage induced by "intense physical activity;
3. Strengthening of the immune defenses: melatonin could be particularly useful to avoid the drop in the immune defenses, which follows intense training and which characterizes the overtraining syndrome;

To date, there have been no particular improvements in performance or body composition following the intake of melatonin.

Method of use recommended by the company - Melatonin 3 Sublingual - Jamieson

Dissolve a small plate under the tongue before going to bed

Method of use in sports Melatonin 3 Sublingual - Jamieson

Given the pharmaceutical formulation proposed by the company, the only dosage that can be carried out in this case is that of 3 milligrams / day, despite the fact that in recent experimental evidence, effects that can be superimposed at significantly lower dosages have been recorded.
In this case, moreover, it is necessary to consider the greater bioavailability of the product (which skips the hepatic metabolism of the first pass) and the faster absorption kinetics, which causes the plasma peak to occur immediately after its administration, suggesting its use. before bedtime for a night's rest.

Synergy - Sublingual Melatonin 3 - Jamieson

Several studies seem to agree on the greater effectiveness of the synergy when taken together with zinc. A generalized improvement is in fact obtained both on the strengthening of the immune defenses and on the antioxidant effect and on the metabolic aspect, improving the sensitivity to insulin.

Some studies show that in case of prolonged intake of zinc and melatonin, supplementation with magnesiomagnesium is also necessary.
The validity of the simultaneous administration of melatonin and vitamin B6 is still under observation, even if the first works show an improvement in the endogenous synthesis of this hormone, with an enhancement of the biological effects related above all to the modulation of the immune and hormonal activity.

Side Effects Sublingual Melatonin 3 - Jamieson

Although recent studies have confirmed the high tolerability and safety of the active ingredient, there are cases in the literature in which, even at a dose of 3 mg / day, nausea, irritability, nightmares and vascular alterations have been observed.
Furthermore, by acting as a mild hypnotic and sedative, melatonin may interfere with the ability to concentrate. By enhancing the immune response, the substance could also worsen the conditions of patients with allergic or autoimmune diseases.

Precautions for use Melatonin 3 Sublingual - Jamieson

The product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, allergies and autoimmune diseases, during pregnancy, during lactation, under the age of 12 and for adolescents not yet trained.
In case of prolonged use (over 6/8 weeks) the doctor's opinion is necessary.

This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of Sublingual Melatonin 3 - Jamieson.

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