About ALA FX - Anderson - Alpha Lipoic Acid
ALA FX - ANDERSON
Food supplement based on alpha-lipoic acid, Vitamins E and Coenzyme Q10
FORMAT
Bottle of 100 cps, 450mg each
COMPOSITION
Alpha Lipoic Acid
Vitamin E: alpha tocopherol acetate
Coenzyme Q10
Thickener: microcrystalline cellulose
Anti-caking agents: silica dioxide and Magnesium stearate
One capsule contains: Alpha Lipoic Acid 300mg; Vitamin E 12 mg; Coenzyme Q10 10mg
Product Features ALA FX - Anderson - Alpha Lipoic Acid
Alpha Lipoic Acid 300mg - also known as thioctic acid, for years it has been considered exclusively for its action as an enzymatic cofactor in the oxidative decarboxylation reaction of pyruvate, alpha ketoglutarate and branched-chain amino acids, leaving out instead what is today the reason for its main use: antioxidant power. Without prejudice to its key role as a cofactor of oxidative metabolism, thus guaranteeing the correct energy flow, alpha lipoic acid is also part of the body's antioxidant potential, so much so that it has been defined the prince of antioxidants, for its direct role in the control of ROS (reactive oxygen species), and for its regenerative capacity of other key molecules in the protection from oxidative stress, such as Vitamin E, Vitamin C and glutathione. Recently, moreover, it has been observed how lipoic acid can guarantee a better uptake of cellular glucose, assisting the insulin signal. All these characteristics have led the various researchers to clinical trials, obtaining very important results in the treatment of oxidative damage pathologies. , such as diabetic neuropathy, Alzheimer's disease, multiple sclerosis, atherosclerotic cardiovascular and hepatic diseases.
Furthermore, its good intestinal absorption, and the bioavailability attested to around 30/40%, make the oral supplement an excellent source of lipoic acid (better than food).
The benefits proposed in the sports field by the manufacturers, many of which are not supported by scientific literature, should concern the increase in lean mass, the decrease in fat mass, the protection of the muscle from oxidative damage, and the optimization of the recovery phase.
Many studies show how the integration of antioxidants, especially if taken together, can greatly improve the antioxidant capacity of the body and counteract the oxidative damage that generally occurs following intense physical activity; consequently these supplements help to reduce the feeling of fatigue and improving the recovery phase.
Vitamin E 15 mg- it is present in nature with 8 different forms, among which the most biologically active is alpha tocopherol. This fat-soluble vitamin is introduced through the diet (olive oil, oil seeds, some cereals), and absorbed in the small intestine with a passive diffusion mechanism mediated by bile salts, with an efficiency of 30/40%. First through the lymphatic system, then through the bloodstream associated with lipoproteins, vitamin E reaches the liver and other tissues, mainly adipose tissue, muscle and adrenal gland, where it can carry out its biological activity. The fundamental role of vitamin E is certainly the antioxidant, preventing from oxidation the PUFA (polyunsaturated fatty acids) present abundantly in the membranes and consequently preserving cellular functionality.In this reaction, however, the alpha tocopherol oxidizes and the alpha tocopheroxy radical loses its antioxidant capacities, which fortunately are mainly restored by vitamin C but also by coenzyme Q10 and lipoic acid. There are many applications of vitamin E in the clinical field, having proved useful in improving oxidative stress pathologies, some of which are very serious such as cancer. Furthermore, numerous studies are evaluating its potential therapeutic effect against cardiovascular and atherosclerotic diseases.
In sports, vitamin E, also associated with other antioxidants, has shown absolute success in reducing oxidative markers, reducing the sensation of fatigue and muscle damage, enhancing the antioxidant capacity of the body and, in some studies, also improving the aerobic capacity.
These studies, however, use a much higher dosage (300mg / day) than the estimated 10 - 12 mg for the daily requirement, taking into account that this may be subject to an increase related to the intake of polyunsaturated fatty acids with diet and style. of life.
Generally daily dosages up to 800 mg / I.U. they do not cause any undesirable effects.
Coenzyme Q10 10mg- belonging to the group of ubiquinones, it is synthesized by our organism, but its production decreases as we age. Furthermore, given the participation of HMG-CoA reductase in its synthesis, statins, commonly used to reduce cholesterol levels, could induce a lowering of the concentration of this molecule. In these cases, integration may become necessary. Like fat-soluble vitamins, the absorption of coenzyme Q10 in the small intestine is favored by the presence of dietary fats.
In sports, supplements ranging from 150 to 300mg per day for at least 2 weeks have been shown to be effective in reducing markers of muscle damage (creatinkinase and myoglobin), oxidative damage (malondialdehyde) and consequently the sensation of fatigue.
The daily requirement is about 5mg, but this rises to 50mg after the age of 35.
Directions for use recommended by the company - ALA FX - Anderson - Alpha lipoic acid
1 capsule a day in a little water on a full stomach.
Directions for use in sports ALA FX - Anderson - Alpha lipoic acid
The dosages recorded in the scientific literature, relating to the sports application of alpha-lipoic acid, are around 600 mg / day, with methods of intake that are not entirely clear. However, the antioxidant effect, which we reiterate is the ONLY scientifically proven in healthy subjects subjected to exercise, in conjunction with other antioxidants, was also achieved at lower dosages, around 150mg / day. As for the timing of intake, in this case also given the presence of two fat-soluble molecules, it would be optimal to take the supplement during meals.
Product Features - ALA FX - Anderson - Alpha Lipoic Acid
The product, consisting of both alpha lipoic acid and vitamin E and coenzyme Q10, certainly focuses on the antioxidant potential of these molecules, which could prevent muscle damage and facilitate the recovery phase. On the other hand, the ergogenic properties, which would derive from an improvement in metabolic performance induced by lipoic acid (cellular uptake of glucose, support of oxidative processes) and by coenzyme Q10 (enhancement of the transport of electrons on the respiratory chain), must be demonstrated.
Rationale for use - ALA FX - Anderson - Alpha lipoic acid
The therapeutic effects of alpha lipoic acid in the treatment of numerous pathologies are well demonstrated. Few studies have been carried out, however, on its application in the sports field; however, from these studies it emerges the antioxidant role, which is carried out in the reduction of damage markers. muscle oxidative, and in the increase of important antioxidants such as glutathione in its reduced form.
The association of lipoic acid, vitamin E and other antioxidants has already been documented in the literature, proving to be effective in reducing oxidative markers following physical exercise.
Side Effects ALA FX - Anderson - Alpha Lipoic Acid
At doses above 1200mg / day side effects such as itching, tingling and affections of the gastrointestinal tract (diarrhea, vomiting and abdominal cramps) have been documented.
Precautions for use ALA FX - Anderson - Alpha lipoic acid
Contraindicated in cases of renal, hepatic, diabetic, pregnancy and lactation pathology.
ALA FX - Anderson - Alpha lipoic acid interactions
Pharmacological - given the ability of lipoic acid to activate the intake of intracellular glucose, the simultaneous intake of hypoglycemic agents could have an unexpected and marked hypoglycemic effect; it is therefore necessary to consult your doctor before use.
Food - given the very similar structure to biotin, the two molecules could compete for the membrane transporter.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of ALA FX - Anderson - Alpha Lipoic Acid.
Int J Sport Nutr Exerc Metab. 2003 Sep; 13: 294-302.
Effect of alpha-lipoic acid combined with creatine monohydrate on human skeletal muscle creatine and phosphagen concentration.Burke DG, Chilibeck PD, Parise G, Tarnopolsky MA, Candow DG.
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer "s disease.
Shenk JC, Liu J, Fischbach K, Xu K, Puchowicz M, Obrenovich ME, Gasimov E, Alvarez LM, Ames BN, Lamanna JC, Aliev G.
J Neurol Sci. 2009 Aug 15; 283 (1-2): 199-206. Epub 2009 Apr 1.
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.
Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J.
Neurochem Res. 2009 Apr; 34: 755-63. Epub 2008 Oct 10.
Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.
McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF Jr, Vita JA.
J Clin Hypertens (Greenwich). 2007 Apr; 9: 249-55.
Mitochondrial membrane damage during aging process in rat heart: potential efficacy of L-carnitine and DL alpha lipoic acid.
Savitha S, Panneerselvam C.
Mech Aging Dev. 2006 Apr; 127: 349-55. Epub 2006 Jan 20.
Antioxidant therapy in human endocrine disorders.
Golbidi S, Laher I.
Med Sci Monit. 2010 Jan; 16: RA9-24. Review.PMID: 20037503 [PubMed - indexed for MEDLINE] Related citations
Antioxidant properties of an endogenous thiol: Alpha-lipoic acid, useful in the prevention of cardiovascular diseases.
Ghibu S, Richard C, Vergely C, Zeller M, Cottin Y, Rochette L.
J Cardiovasc Pharmacol. 2009 Nov; 54: 391-8. Review.
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM.
Biochim Biophys Acta. 2009 Oct; 1790: 1149-60. Epub 2009 Aug 4. Review.
Nutritional supplementation for type 2 diabetes: a systematic review.
Bartlett HE, Eperjesi F.
Ophthalmic Physiol Opt. 2008 Nov; 28: 503-23. Review.
Alpha-lipoic acid supplementation and diabetes.
Singh U, Jialal I.
Nutr Rev. 2008 Nov; 66: 646-57. Review.
Alpha-lipoic Acid Improves Endothelial Dysfunction in Patients with Subclinical Hypothyroidism.
Gd X, Jh P, Hl S, Ls Z.
Exp Clin Endocrinol Diabetes. 2010 Feb 16. [Epub ahead of print]
Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial.
Heinisch BB, Francesconi M, Mittermayer F, Schaller G, Gouya G, Wolzt M, Pleiner J.
Eur J Clin Invest. 2010 Feb; 40: 148-54. Epub 2009 Dec 27.
Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise.
Zembron-Lacny A, Slowinska-Lisowska M, Szygula Z, Witkowski K, Stefaniak T, Dziubek W.
J Physiol Pharmacol. 2009 Jun; 60: 139-43.
Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome.
Wray DW, Uberoi A, Lawrenson L, Bailey DM, Richardson RS.
Clin Sci (Lond). 2009 Mar; 116: 433-41.
Effects of antioxidant supplementation and exercise training on erythrocyte antioxidant enzymes.
Marsh SA, Laursen PB, Coombes JS.
Int J Vitam Nutr Res. 2006 Sep; 76: 324-31.
Endocr Pract. 2002 Jan-Feb; 8: 29-35.
Evans JL, Heymann CJ, Goldfine ID, Gavin LA.
Eur J Clin Pharmacol. 1996; 50: 513-4.
Gleiter CH, Schug BS, Hermann R, Elze M, Blume HH, Gundert-Remy U.
Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation.
Oksala NK, Laaksonen DE, Lappalainen J, Khanna S, Nakao C, Hänninen O, Sen CK, Atalay M.
alpha-Lipoic acid modulates thiol antioxidant defenses and attenuates exercise-induced oxidative stress in standardbred trotters.
Kinnunen S, Oksala N, Hyyppä S, Sen CK, Radak Z, Laaksonen DE, Szabó B, Jakus J, Atalay M.
Free Radic Res. 2009 Aug; 43: 697-705.
Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude.
Bailey DM, Davies B.
High Alt Med Biol. 2001 Spring; 2: 21-9.
Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.
Rosenfeldt F, Hilton D, Pepe S, Krum H. Biofactors. 2003; 18 (1-4): 91-100. Review.
The effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men.
Gökbel H, Gül I, Belviranl M, Okudan N. J Strength Cond Res. 2010 Jan; 24: 97-102.
Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals.
Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen C, Greenwood M, Leutholtz B, Willoughby D, Kreider R.J Int Soc Sports Nutr. 2008 Mar 4; 5: 8.
