Information on Strato GH - KEFORMA
GH - KEFORMA layer
Food supplement based on Arginine aspartate and Ornithine alpha keto-glutarate
FORMAT
Bottle of 60 capsules
COMPOSITION
Arginine aspartate
Ornithine Alpha Keto Glutarate (OKG)
Vitamin B6
Capsule: food gelatin
One serving (four capsules) contains: Arginine aspartate 2.6 gr
OKG 1.4gr
Vitamin B6 2.4 mg
It is then introduced through the diet, being abundant in peanuts, meats and legumes. After ingestion it is absorbed in the intestine and distributed in various tissues, with particular importance in the liver, where it allows the urea cycle to advance, with consequent detoxification from ammonia derived from the common process of amino acid oxidation.
Arginine is also involved in numerous other biological reactions and, through the formation of numerous metabolites, plays an important role in the regulation of the immune response, cell replication, hormonal response and protein synthesis.
For this reason, arginine has found various applications in the therapeutic field, supported by various studies, and in the sports field.
In fact, in common sports practice, arginine-based supplements are used to stimulate the synthesis of nitric oxide, thus improving muscle vascularization and the consequent supply of oxygen and nutrients, and to increase the synthesis of creatine and enhance the release of GH.
As can be seen later in the text, there is an important debate regarding the aforementioned effects of arginine.
Ornithine Alpha Keto Glutarate (OKG): synthetic product consisting of the union of two ornithine molecules through an alpha keto-glutarate bridge.
Ornithine, produced in our organism following the action of the arginase enzyme that splits arginine into urea, represents the starting stage of the urea cycle, thus returning on one hand to the detoxification of amino residues derived from oxidation amino acids, and on the other in the regeneration of arginine.
The effects related to supplementation with this molecule are not yet well documented, and mainly oriented in supporting protein synthesis in models and patients subjected to burns and trauma. Furthermore, some studies show the ability of this molecule to support the production of nitric oxide (although the mechanism is still unknown), and to increase insulin secretion in a glucose-dependent manner (probably due to the gluconeogenic role of alpha keto -glutarate). However, the role established by several studies is to increase the synthesis of arginine, proline and polyamines, facilitating muscle recovery from severe trauma such as fractures and burns. There are no studies in the literature relating to the application of OKG in sports.
Vitamin B6: introduced in the form of pyridoxine, very present in meat, wholemeal products, liver, fish, egg white, corn, milk, fruit, green vegetables, brewer's yeast and germ oil of wheat, pyridoxine is absorbed in the intestine and from there it reaches the liver where it is stored.
Its biological activity is carried out in the phosphorylated form, pyridoxal phosphate, and is part of the amino acid metabolism, lipid metabolism, the synthesis of various neutransmitters, glycogenolysis and gluconeogenesis, in the synthesis of nucleotides and in the detoxification of homocysteine.
Its supplementation has been successfully carried out proving effective in improving cognitive, metabolic and immune abilities.
Its daily requirement is around 1 / 1.5 mg, but even in this case the cases of deficiency are very rare. Massive doses of this vitamin (greater than 50 mg / day) can cause peripheral neuropathies.
Uses in sports - GH layer - KEFORMA
Like the supplements described in this section, the results sought by its use in sports are related to the "increase in lean mass, the" increase in GH secretion, the improvement of athletic performance.
Product features Strato GH - KEFORMA
The product in question associates vitamin B6 and OKG with arginine. Surely one of the objectives of this synergy is to support the correct amino acid metabolism, increasing protein synthesis and regularizing ammonia detoxification.
Definitely, as can be easily deduced from the name, this supplement also aims at increasing the secretion of growth hormone, but the data obtained from the scientific world seem somewhat contradictory.
Rationale for use - GH layer - KEFORMA
Although a recent study has shown an increase in GH in 9 athletes subjected to supplementation for three weeks of arginine and ornithine, the scientific world seems to agree on the "absence of the" stimulatory effect on GH secretion, both by "ornithine and" arginine, in healthy and exercised individuals.
Common practice, but nevertheless erroneous, is to generalize the results obtained on guinea pigs or on individuals suffering from particular pathologies or on intravenous administrations at very high concentrations, extending them to the sports world. This was done with the OKG, for which no studies on healthy individuals and / or athletes are yet documented.
Several studies, on the other hand, seem to agree on the increase of muscle energy capacity, on preserving amino acids from oxidation and on improving athletic performance, all benefits that would derive from arginine supplementation especially if associated with BCAAs and creatine.
Method of use recommended by the company
Swallow 4 capsules a day.
Method of use in sports - Layer GH - KEFORMA
Arginine: the various studies carried out on athletes use quite varied dosages, from 2 to 8 g per day (best results obtained at dosages of 3 g / day), to improve physical performance and reduce the feeling of fatigue.
The dosages used to increase GH secretion are generally higher and can even reach up to 15 grams per day, a dose at which side effects can occur.
Administration on an empty stomach is preferred, to avoid competitive phenomena in intestinal absorption.
Ornithine: studies showing positive effects in reducing lactate following physical exercise, consequently also the feeling of fatigue, have used dosages around 2 gr / day for at least 7 days.
Side effects GH - KEFORMA layer
The most common side effects, recorded at large doses, are vomiting, diarrhea and abdominal cramps at doses above 9 grams per day.
Massive doses, generally greater than 30 g, can cause nephrotoxicity, hypotension and headaches.
Ornithine: doses higher than 10/20 g can cause gastrointestinal disorders.
The data relating to the OKG are not sufficient.
Precautions for use Strato GH - KEFORMA
The product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, during pregnancy, during lactation and under the age of 12 and adolescents not yet formed.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Further information on the critical analysis of Strato GH - KEFORMA.
Crit Care Med. 2000 Jun; 28: 1772-6.
Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls.Coudray-Lucas C, Le Bever H, Cynober L, De Bandt JP, Carsin H.
Chronic arginine aspartate supplementation in runners reduces total plasma amino acid level at rest and during a marathon run.
Colombani PC, Bitzi R, Frey-Rindova P, Frey W, Arnold M, Langhans W, Wenk C.
Eur J Nutr. 1999 Dec; 38: 263-70.
L-ornithine alpha-ketoglutarate in HIV infection: effects on muscle, gastrointestinal, and immune functions.
Karsegard VL, Raguso CA, Genton L, Hirschel B, Pichard C.
Nutrition. 2004 Jun; 20: 515-20.
Nutr Res. 2008 Nov; 28: 738-43.
J Nutr Health Aging. 2009 Aug; 13: 623-30.
Meaume S, Kerihuel JC, Constans T, Teot L, Lerebours E, Kern J, Bourdel Marchasson I.
Department of Gerontology, Charles Foix Hospital, Ivry-sur-Seine, Pari
Sugino T, Shirai T, Kajimoto Y, Kajimoto O.
Int J Sports Med. 2005 Jun; 26: 344-9.
Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism - a randomized, double-blind, placebo-controlled study.Abel T, Knechtle B, Perret C, Eser P, von Arx P, Knecht H.
Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men.
Campbell B, Roberts M, Kerksick C, Wilborn C, Marcello B, Taylor L, Nassar E, Leutholtz B, Bowden R, Rasmussen C, Greenwood M, Kreider R.
Nutrition. 2006 Sep; 22: 872-81.
Chemistry and pharmacology of arginine pyroglutamate. Analysis of its effects on the CNS.
Provenzano PM, Brucato A, Gianguzza S, Coppola A, Orzalesi G, Selleri R, Innocenti F, Volpato I.
J Physiol Pharmacol. 2008 Aug; 59 Suppl 1: 91-106.
Biological effects of 2-oxoglutarate with particular emphasis on the regulation of protein, mineral and lipid absorption / metabolism, muscle performance, kidney function, bone formation and cancerogenesis, all viewed from a healthy aging perspective state of the art - review article.Harrison AP, Pierzynowski SG.
Amino Acids. 2009 May; 37: 153-68. Epub 2008 Nov 23.
Arginine metabolism and nutrition in growth, health and disease.
Wu G, Bazer FW, Davis TA, Kim SW, Li P, Marc Rhoads J, Carey Satterfield M, Smith SB, Spencer TE, Yin Y.
Curr Opin Clin Nutr Metab Care. 2008 Jan; 11: 50-4.
Growth hormone, arginine and exercise.
Kanaley JA.
Ann Pharmacother. 2001 Jun; 35: 755-64.
L-arginine in the management of cardiovascular diseases.
Cheng JW, Baldwin SN.
Risk assessment for the amino acids taurine, L-glutamine and L-arginine.
Shao A, Hathcock JN.
Regul Toxicol Pharmacol. 2008 Apr; 50: 376-99. Epub 2008 Jan 26. Review.
J Nutr. 2007 Jun; 137 (6 Suppl 2): 1681S-1686S.
Arginine and immunity.
Popovic PJ, Zeh HJ 3rd, Ochoa JB.
Chronic but not acute oral L-arginine supplementation delays the ventilatory threshold during exercise in heart failure patients.
Doutreleau S, Mettauer B, Piquard F, Schaefer A, Lonsdorfer E, Richard R, Geny B.
Can J Appl Physiol. 2005 Aug; 30: 419-32.
Use of amino acids as growth hormone-releasing agents by athletes.
Chromiak JA, Antonio J.
Nutrition. 2002 Jul-Aug; 18 (7-8): 657-61. Review.
Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes.
Zajac A, Poprzecki S, Zebrowska A, Chalimoniuk M, Langfort J.
J Strength Cond Res. 2010 Apr; 24: 1082-90.
Arginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trial.
Chen S, Kim W, Henning SM, Carpenter CL, Li Z.
J Int Soc Sports Nutr. 2010 Mar 23; 7: 13. [Epub ahead of print]
Creatine, arginine alpha-ketoglutarate, amino acids, and medium-chain triglycerides and endurance and performance.
Little JP, Forbes SC, Candow DG, Cornish SM, Chilibeck PD.
Int J Sport Nutr Exerc Metab. 2008 Oct; 18: 493-508.
No effect of short-term arginine supplementation on nitric oxide production, metabolism and performance in intermittent exercise in athletes.
Liu TH, Wu CL, Chiang CW, Lo YW, Tseng HF, Chang CK.
J Nutr Biochem. 2009 Jun; 20: 462-8. Epub 2008 Aug 15.
Int J Sport N. 1993 Sep; 3: 298-305.
Failure of commercial oral amino acid supplements to increase serum growth hormone concentrations in male body-builders.Lambert MI, Hefer JA, Millar RP, Macfarlane PW
. Effect of L-arginine supplementation on secretion of human growth hormone and insulin-like growth factor in adults]
Fayh AP, Friedman R, Sapata KB, Oliveira AR.
Arq Bras Endocrinol Metabol. 2007 Jun; 51: 587-92. Portuguese.
Oral arginine attenuates the growth hormone response to resistance exercise.
Collier SR, Collins E, Kanaley JA.
J Appl Physiol. 2006 Sep; 101: 848-52. Epub 2006 Jun 1.
Adverse gastrointestinal effects of arginine and related amino acids.
Grimble GK.
J Nutr. 2007 Jun; 137 (6 Suppl 2): 1693S-1701S. Review.
Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults.
Marcell TJ, Taaffe DR, Hawkins SA, Tarpenning KM, Pyka G, Kohlmeier L, Wiswell RA, Marcus R.
J Gerontol A Biol Sci Med Sci. 1999 Aug; 54: M395-9.
Br J Clin Pharmacol. 1999 Mar; 47: 261-6.
Tangphao O, Grossmann M, Chalon S, Hoffman BB, Blaschke TF.
Branched-chain amino acids and arginine supplementation attenuates skeletal muscle proteolysis induced by moderate exercise in young individuals.
Matsumoto K, Mizuno M, Mizuno T, Dilling-Hansen B, Lahoz A, Bertelsen V, Münster H, Jordening H, Hamada K, Doi T.
Int J Sports Med. 2007 Jun; 28: 531-8. Epub 2007 May 11. Erratum in: Int J Sports Med. 2007 Jul; 28: 63
Effects of Arginine-Based Supplements on the Physical Working Capacity at the Fatigue Threshold.
Camic CL, Housh TJ, Zuniga JM, Hendrix RC, Mielke M, Johnson GO, Schmidt RJ.
J Strength Cond Res. 2010 Apr 9.
Curr Med Res Opin. 1981; 7: 475-81.
Int J Sport Nutr. 1993 Sep; 3: 298-305.
Failure of commercial oral amino acid supplements to increase serum growth hormone concentrations in male body-builders.Lambert MI, Hefer JA, Millar RP, Macfarlane PW.
