About HMB - EAS
HMB - EAS
Food supplement based on hydroxy beta methyl butyrate
FORMAT
200 cps bottle
COMPOSITION
Hydroxy beta methylbutyrate (HMB): salified with calcium
Capsule: food gelatin
Anti-caking agents: Magnesium stearate, silicon dioxide, Potassium phosphate e
Calcium phosphate
One capsule contains: 250 mg hydroxy beta methyl butyrate
Product features HMB - EAS
Hydroxy beta methyl butyrate- not very present in nature (fish is the best source), it is a derivative of the alpha keto isocaproate, a ketoacid originated following the transamination of the branched chain amino acid leucine. The supplement therefore represents the best source of intake. Preliminary studies on pharmacokinetics have shown that at the oral dose of 1g, a plasma peak occurs after 2h, with a renal elimination of approximately 14% of the original dose. At the dose of 3 g, however, the blood peak is anticipated by the hour, while the clearance reaches 29%. The concomitant administration of glucose delays the peak by about one hour, but its clearance remains unchanged. Still unclear is the subsequent distribution of this molecule among the various tissues, and the possible efficacy of mediated insulin intake, as is the case for branched-chain amino acids.
Just as the biological mechanism of functioning of HMB is still unclear, but it is certainly involved in the modulation of protein homeostasis.
It is presumed to have a direct role in improving protein synthesis, and in inhibiting protein degradation via ubiquitin proteasome. Furthermore, from studies carried out on animal models, it appears to have an antioxidant and antiapoptotic potential which, however, still needs to be characterized.
The "interest of HMB from a commercial point of view is due to the effects recorded on cachectic individuals, on elderly individuals and on animal models, in which the administration of HMB has significantly improved protein turnover, significantly increasing lean mass and exhibiting a potential beneficial effect on the lipidemic and immune profile.
Naturally, the application in the sports field makes sense, given the modulatory role in protein synthesis.
Rationale for integrating HMB - EAS into sports practice
From a recent review, which examined all the studies in the literature relating to the "use of" HMB in sports, it emerged that about 394 individuals were enrolled (still few to draw statistically significant conclusions) and that the results seem be somewhat discordant. However, it seems that the best ergogenic effects are recorded on untrained individuals, with an increase in maximum strength, and a reduction in markers of muscle damage induced by physical activity, while integration in trained individuals seems to be ineffective. The variation in body composition induced by HMB is also not very significant, identifiable only on untrained individuals, for which the individual variability of the response to physical exercise must also be taken into account.
Method of use recommended by the company - HMB - EAS
It is recommended to take 4 capsules 3 times a day.
Method of use in sports practice HMB - EAS
In the studies in which encouraging results are recorded, the established dosage is that of 3 g per day, while from pharmacokinetic tests the optimal one seems to be 38 mg / kg.
Acute administration is completely ineffective, and the various studies seem to agree on this. In order to minimize the renal elimination of the product, it would be advisable to divide the daily dosage into 3 doses of 1 g, while there is still no evidence on the absorption efficacy of HMB on an empty or full stomach.
The product in question presents capsules with 250 mg of HMB each, with inevitably pros and cons:
- PRO: possibility to significantly modulate the dosage;
- CONS: many capsules to ingest to reach the dosage of 3 gr.
The suggested timing of administration includes 1 gr at breakfast, one post workout and one before bedtime, for at least 4 weeks. However, the mechanism of action has not yet been clarified, the potential benefits that could derive from a pre-workout administration are not known, taking into account that the plasma peak is obtained after 2h, for the dose of 1 g.
How to optimize your HMB - EAS business
The synergy with creatine seems completely ineffective and documented by several studies.
More rational, and theoretically justified but experimentally not yet proven, could be the simultaneous administration of BCAA, enhancing the anti-catabolic effect of HMB.
On the contrary, the beneficial effect of preserving and increasing lean mass has been demonstrated, obtained following the administration of HMB with arginine and glutamine in cancer patients and AIDS patients, and of HMB with arginine and lysine in elderly men and women.
HMB side effects - EAS
The administration of HMB appears to be well tolerated at doses ranging from 3 to 6 grams per day, and well documented in the literature even for several weeks of administration.
Animal studies also show that very high doses are however tolerated.
A reduction in blood pressure has been recorded in some studies following the administration of HMB, but this appears to be due to the presence of calcium in the product.
Precautions for use HMB - EAS
The product is contraindicated in cases of renal or hepatic pathology, cardiovascular disease and / or hypertension, in pregnancy, during lactation, under 12 years and in adolescents not yet trained.
In case of prolonged use (over 6/8 weeks) the doctor's opinion is necessary.
This article, elaborated on the critical rereading of scientific articles, university texts and common practice, is for information purposes only and therefore has no medical prescription value. It is therefore always required to consult your doctor, nutritionist or pharmacist before undertaking the use of any supplement.. Learn more about the critical analysis of HMB - EAS.
The prevention and treatment of exercise-induced muscle damage.
Howatson G, van Someren KA.
Sports Med. 2008; 38: 483-503. Review.
Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength.
Slater GJ, Jenkins D.
Sports Med. 2000 Aug; 30: 105-16. Review.
Beta-hydroxy-beta-Methylbutyrate and its use in athletics.
Palisin T, Stacy JJ.
Curr Sports Med Rep. 2005 Aug; 4: 220-3. Review.
Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta-methylbutyrate and alpha-ketoisocaproic acid supplementation.
Nunan D, Howatson G, van Someren KA.
J Strength Cond Res. 2010 Feb; 24: 531-7.
Mechanism of attenuation by beta-hydroxy-beta-methylbutyrate of muscle protein degradation induced by lipopolysaccharide.
Russell ST, Tisdale MJ.
Mol Cell Biochem. 2009 Oct; 330 (1-2): 171-9. Epub 2009 Apr 30.
Effects of nine weeks of beta-hydroxy-beta- methylbutyrate supplementation on strength and body composition in resistance trained men.
Thomson JS, Watson PE, Rowlands DS.
J Strength Cond Res. 2009 May; 23: 827-35.
Effects of beta-hydroxy-beta-methylbutyrate supplementation during resistance training on strength, body composition, and muscle damage in trained and untrained young men: a meta-analysis.
Rowlands DS, Thomson JS.
J Strength Cond Res. 2009 May; 23: 836-46.
Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage.
Wilson JM, Kim JS, Lee SR, Rathmacher JA, Dalmau B, Kingsley JD, Koch H, Manninen AH, Saadat R, Panton LB.
Beta-hydroxy-beta-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-kappaB expression.
Nunes EA, Kuczera D, Brito GA, Bonatto SJ, Yamazaki RK, Tanhoffer RA, Mund RC, Kryczyk M, Fernandes LC.
Nutr Res. 2008 Jul; 28: 487-93.
Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues.
Holecek M, Muthny T, Kovarik M, Sispera L.
Food Chem Toxicol. 2009 Jan; 47: 255-9. Epub 2008 Nov 21.
Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review.
Wilson GJ, Wilson JM, Manninen AH.
Nutr Metab (Lond). 2008 Jan 3; 5: 1.
J Appl Physiol. 1996 Nov; 81: 2095-104.
Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training.
Int J Sport Nutr Exerc Metab. 2001 Dec; 11: 442-50.
Paddon-Jones D, Keech A, Jenkins D.
J Nutr Biochem. 2001 Nov; 12: 631-639.
Effects of amino acids supplement on physiological adaptations to resistance training.
Kraemer WJ, Hatfield DL, Volek JS, Fragala MS, Vingren JL, Anderson JM, Spiering BA, Thomas GA, Ho JY, Quann EE, Izquierdo M, Häkkinen K, Maresh CM.
Med Sci Sports Exerc. 2009 May; 41: 1111-21.
Effects of six weeks of beta-hydroxy-beta-methylbutyrate (HMB) and HMB / creatine supplementation on strength, power, and anthropometry of highly trained athletes.
O "Connor DM, Crowe MJ.
J Strength Cond Res. 2007 May; 21: 419-23.
The effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB / creatine supplementation on indices of health in highly trained athletes.
Crowe MJ, O "Connor DM, Lukins JE ..
Effects of beta-hydroxy-beta-methylbutyrate and creatine monohydrate supplementation on the aerobic and anaerobic capacity of highly trained athletes.
O "Connor DM, Crowe MJ.
A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122).
Berk L, James J, Schwartz A, Hug E, Mahadevan A, Samuels M, Kachnic L; RTOG.
Support Care Cancer. 2008 Oct; 16: 1179-88. Epub 2008 Feb 22.
Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine.
Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen S, Flakoll P.
JPEN J Parenter Enteral Nutr. 2009 Jan-Feb; 33: 71-82.
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