THE CONNECTIVE SYSTEM: CONNECTIVE NETWORK AND PSYCHONEUROENDOCRINE-CONNECTIVEIMMUNOLOGY - PHYSIOLOGY

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The connective system

Edited by Dr. Giovanni Chetta

Giovanni Chetta

Connective network

The total structure consisting of extracellular matrix, membrane receptors (integrins) and intracellular matrix constitutes our spatial body (hence the concept of "medicine and space health"). We are faced with a real continuous and dynamic supramolecular network that extends into every corner and body space composed of a nuclear matrix inside a cellular matrix immersed in an extracellular matrix. The connective network is a continuum that connects both structurally and functionally, giving shape and allowing the life of our organism.
Unlike the networks formed by the nervous, endocrine and immune systems, the connective system presents a perhaps apparently more archaic, but certainly no less important method of communication: the mechanical one. It "simply" pulls and pushes, thus communicating from fiber to fiber, from cell to cell and from internal and external environment to the cell and vice versa, through the fibrous web, the fundamental substance and sophisticated mechanical signal transduction systems. This type of communication occurs outside our state of consciousness and has so far been studied much less than nervous and circulatory communication.
It is also necessary to consider that the connective system, in addition to representing itself an indispensable network for the development and life of all the components of the organism, constitutes the integrated substrate that allows the other networks (nervous, endocrine, and immune) to exist, act and communicate with each other In other words, it is at the same time an integrated communication system with the others as well as the physically and functionally supporting structure of them, therefore of the organic global network.
At the same time, the endocrine, immune and nervous systems are able to involve profound changes in the connective system such as, for example, in the healing and inflammatory processes or, simply, considering the fascial changes caused by the muscles through the nervous system (we can consider in actually the muscles as a "single jelly, which rapidly changes its state in response to a nerve stimulus, contained within 650 connective pockets). Another factor that can have a preponderant effect on the connective system is "nutrition (scurvy, for example, is a disease characterized by" extensive degeneration of the connective tissue due to vitamin C deficiency, in the absence of which the fibroblasts cease to synthesize collagen).

Psychoneuroendocrine connectiveimmunology

The human organism therefore functions as an integrated network that unifies the various organs and systems. The codes are the same and the substrate is common to the whole network. Whether they are the brain circuits, activated by emotions, thoughts, or the nervous circuits vegetative, activated by stress or feedback from organs or systems, whether it is the endocrine or immune organs, or whether it is connective mechanical tensions, through movement and muscle activation, to emit messages, the latter, in their fundamental part, will be recognized by all the components of the network.The language is unique, the connection is integrated and two-way.
It is evident that the therapeutic approach can exploit this possibility of plurality of inputs to the "great connection". On this basis, in fact, the interventions can be multiple: nutrition education, pharmacotherapy, instrumental therapies, psychotherapy, body techniques, ergonomic techniques, etc. The task of the therapeutic intervention is to favor the restoration of the physiological balanced communication between the systems.
The importance of further research in this field appears clear. We cannot ignore the study of the connective system if we want to fully understand the global and local physiological behavior. The study of biochemistry can no longer be simplified into linear sequences of chemical reactions. physical but it is necessary to consider the "active and dynamic habitat in which the" chemistry of life "takes place, that is the material that the biochemists discard by purifying the" soluble "enzymes and through which the surgeons make their way in their interventions: the connective system.

Psychoneuroendocrinommunology should therefore be extended to

psychoneuroendocrine connectiveimmunology.

The very development of "energy" therapies cannot do without an in-depth analysis of the connective system in order to understand the physiology of the magnetic circuits produced by the flow of electrical charges in the organism.
Finally, it is necessary to underline on the basis of what has been argued so far, how modern techniques and manual therapies, movement and postural re-education, based on the concept of re-harmonization of the connective system in accordance with the other systems, can have important and immediate effects as well as long duration on the general health of the organism.

Essential bibliography:

Ader R., "Psychoneuroimmunology", Academic press

Don W. Fawcett, "Bloom & Fawcett Treatise on Histology". McGraw-Hill,

Hynes R, "Integrins: bidirectional, allosteric signaling machines". Cell 110: 673-87

Ingber D., "The architecture of life", Scientific American January 1998: 48-57

Matthew J. Paszek, et al., "Tensional homeostasis and the malignant phenotype". Cancer Cell, Vol. 8, pp. 241-254. DOI 10.1016 / j.ccr.2005.08.010 (September 2005)

Myers T, "" Anatomy Trains ", New Techniques

Oschman J.L., "Energy Medicine: the scientific basis", Churchill Livingstone

Rolf I.P., "Rolfing", Mediterranean Editions