The distribution of a drug in the organism can be influenced by various factors related to the subject. We recall that we speak of distribution to indicate the process by which a drug passes from one part of the body to another until it reaches the site of action.
Age
Hypoalbuminemia in the elderly and in the newborn; presence of fetal albumin with reduced binding capacity in the newborn; presence of endogenous displacing metabolites in the elderly and in the newborn.
Pregnancy
Hypoalbuminemia; variations in the volumes of the body water compartments.
Stay in bed
Deterioration of circulatory function.
Liver diseases
Hypoalbuminemia; accumulation of endogenous metabolites displacing.
Nephropathies
Hypoalbuminemia; reduction of the binding capacity of albumin.
Severe burns, infectious and inflammatory diseases, trauma, surgery, neoplasms, ulcerative colitis.
Hypoalbuminemia; increase in the concentration of orosomucoid (protein of the acute phase of inflammation that binds various drugs).
Other articles on "Factors that change drug distribution"
- Binding of a drug to plasma proteins
- Distribution of a drug
