SPASMEX ® Phloroglucine dihydrate

SPASMEX ® is a drug based on phloroglucin dihydrate

THERAPEUTIC GROUP: Spasmolytics / drugs for intestinal function disorders

Indications SPASMEX ® Phloroglucine dihydrate

SPASMEX ® is indicated in the symptomatic treatment of spastic pain in the smooth muscles of the gastrointestinal, urogenital and biliary tract.

Mechanism of action SPASMEX ® Phloroglucine dihydrate

SPASMEX ® characterized by a very short plasma half-life (15 minutes), once absorbed tends to concentrate mainly in the gastrointestinal, urogenital and biliary tracts, where it will carry out its therapeutic action.
The efficacy of SPASMEX ® in the treatment of spasm is linked to the presence of the active principle phloroglucin / phloroglucinol, characterized by a direct spasmolytic activity against the smooth muscle cells of the aforementioned anatomical areas. The biological mechanism underlying this property provides for the inhibition of the enzyme catechol-o-methyl-transferase, which is important in the normal metabolism of catecholamines, responsible for the spasm.

Studies carried out and clinical efficacy

1. SPASMEX AND CYSTITIS

Urology. 2004 Mar-Apr;: 23-5.

[The combined treatment of interstitial cystitis in women with spasmex]

Klochikhin OZ, Volkov DIu, Vostokova EI, Zhulina NI.

SPASMEX has proved particularly effective in quickly relieving painful symptoms, improving the quality of life, reducing temporary disability in women with interstitial cystitis. The anticholinergic and spasmolytic effect on the smooth muscles of the uro-genital system was the biological basis for this important success.

2. SPASMEX AND URINARY INCONTINENCE

Urology. 2003 Jul-Aug;: 46-9.

Spasmex treatment of patients with hyperactive urinary bladder]

Pushkar "DIu, Shchaveleva OB.

This study, conducted on 193 patients with urinary incontinence, demonstrated how the use of SPASMEX for 12 weeks can guarantee a reduction in the daily number of bowel movements and incontinence episodes, proving more effective than other drugs of the same pharmaceutical category but with different active principle.

3. CISAPRIDE And dyspepsia

Urology. 2007 May-Jun;: 15-9.

Spasmex in the treatment of lower urinary tract symptoms in patients with neurogenic hyperactive urinary bladder caused by vertebrogenic lesions.

Mazo EB, Babanina GA.

This Russian study conducted on 62 patients shows how SPASMEX treatment can be particularly effective in reducing the number of urinary evacuations in patients with overactive bladder and in "significantly increasing bladder volume. The" most observed side effect was l " onset of constipation.

Method of use and dosage

SPASMEX ® tablets: it is recommended to take 6 tablets per day
SPASMEX ® suppositories: it is recommended to take 3 tablets per day

Warnings SPASMEX ® Phloroglucine dihydrate

Unfortunately, or fortunately, no particular reports have yet been received regarding the use of SPASMEX ® therefore it is strongly recommended to keep the drug out of the reach of children, not to exceed the indicated doses, to consult your doctor before resorting to administration and not to associate it with other major pain relievers.
SPASMEX ® tablets have a source of lactose, so it would be important to carefully evaluate their use in patients with lactose intolerance.
As for the other anticholinergics, it would be advisable to pay particular attention in case of glaucoma, pyloric stenosis, prostatic hypertrophy, intestinal atony, of the elderly, reflux esophagitis, severe ulcerative colitis, myasthenic syndromes.

PREGNANCY AND BREASTFEEDING

The absence of side effects on the health of the child or mother does not place any restrictions on use in the event of pregnancy and breastfeeding. Despite this, it would always be advisable to use SPASMEX ® in case of real need and after consulting your doctor.
There are no studies in the literature that show the effects of SPASMEX ® during the first trimester of pregnancy, therefore it would be better to avoid its intake during this period.

Interactions

At the moment there are no studies showing significant interactions or incompatibilities between SPASMEX ® of other drugs; however, the simultaneous administration of other major pain relievers, antihistamines, tricyclic antidepressants, phenothizains, amantidine, butyrophenomas, which could enhance the therapeutic and toxic effects of the active ingredient, should be avoided.

Contraindications SPASMEX ® Phloroglucine dihydrate

It would be advisable to avoid taking SPASMEX ® in case of hypersensitivity to the drug or to one of its components.

Undesirable Effects - Side Effects

In case of hypersensitivity to one of its components, skin allergic reactions of varying degrees may occur.
The anticholinergic action could cause dry mouth, decreased sweating, mydriasis, accommodation disturbances, increased ocular tone, urinary retention, constipation and sleepiness.

Note

SPASMEX ® can only be purchased upon presentation of a medical prescription.

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