Definition
With the term "endometritis" s "indicates an inflammatory pathology on an infectious basis, which affects the endometrium, ie the mucosa that lines the uterus internally.
This type of inflammation occurs mainly in the immediate post-partum period, but there is still the possibility that endometritis also occurs in women who have not yet given birth and in women in menopause. In this regard, we can distinguish two forms of endometritis: acute endometritis (typical of post-partum) and chronic endometritis (typical in women outside the gestational period).
Causes
Endometritis is caused by a bacterial infection, which can be sustained by microorganisms of different nature, such as: Gram-positive (such as streptococci and staphylococci), gram-negative (such as, for example, Escherichia coli, Klebsiella spp., etc.), anaerobic bacteria (such as, for example, Bacteroides spp.) and other pathogens such as Mycoplasma spp, Ureaplasma spp., etc.
Symptoms
The main symptoms induced by endometritis are: uterine bleeding, menorrhagia, uterine discharge, pain during sexual intercourse, abdominal swelling, headache, fever and generalized weakness.
In addition, the infection can spread and reach the myometrium, in these cases, it is also common to perceive a sensation of pain.
The information on Endometritis - Endometritis Treatment Drugs is not intended to replace the direct relationship between health professional and patient. Always consult your doctor and / or specialist before taking Endometritis - Endometritis Treatment Drugs.
Medicines
Generally, the treatment of endometritis can be effectively carried out through the administration of antibiotic drugs. In fact, in most cases, the symptoms are resolved within 48-72 hours from the start of treatment.
The antibiotics that are usually used are broad spectrum; if, on the other hand, it has been possible to identify the microorganism responsible for the inflammation, then the doctor can decide to institute a more targeted and specific therapy.
The following are the antibiotic drugs most used in the therapy against endometritis and some examples of pharmacological specialties; it is up to the doctor to choose the most suitable active ingredient and dosage for the patient, based on the severity of the disease, the state of health of the patient. patient and his response to treatment.
Doxycycline
Doxycycline is an antibiotic belonging to the tetracyclines class. It is one of the first choice drugs in the treatment of endometritis associated with chlamydia.
Doxycycline is available for oral administration in the form of tablets or capsules. The dose of drug usually used is 100-200 mg per day, to be taken with plenty of water at least one hour before going to bed (to avoid any esophageal irritation).
Clindamycin and Gentamicin
Generally, for the treatment of endometritis associated with chlamydia, clindamycin is administered parenterally in combination with gentamicin, but only when it is not possible to use the first choice antibiotics, ie tetracyclines.
Clindamycin (Dalacin ®, Cleocin ®, Clindamycin phosphate Hikma ®) is an antibiotic belonging to the class of lincosamides and available in the form of pharmaceutical formulations suitable for oral, vaginal and parenteral administration.
The usual dose of clindamycin used is 900 mg of drug per day, to be administered by intravenous infusion.
The dose of gentamicin (Gentalyn ®, Gentomil ®) usually used, on the other hand, is 3-6 mg / kg of body weight, to be administered intravenously 1-2 times a day.
In any case, the doctor will determine, for each patient, the exact quantity of drugs to be used, the frequency of administration and the duration of treatment.
Amoxicillin
Amoxicillin is an antibiotic belonging to the broad spectrum penicillin class. Generally, in the treatment of uncomplicated endometritis, amoxicillin is given in combination with gentamicin and metronidazole.
It is a drug available in pharmaceutical formulations suitable for oral and parenteral administration. When administered via the latter route, the drug dose usually used in adult patients is 500-1,000 mg, to be administered by intramuscular or intravenous injection, or by intravenous infusion, every 8-12 hours.
In any case, the doctor will determine the exact amount of amoxicillin to use for each patient.
Metronidazole
Metronidazole (Deflamon ®) is a drug belonging to the class of nitroimidazole antibiotics. It is available in pharmaceutical formulations suitable for different routes of administration: oral, vaginal and parenteral. When administered through this last route, the dose of drug usually used in adults is 500 mg, to be taken every eight hours. However, the doctor will determine the exact dosage of medicine that each patient should take, also taking account of the fact that, as mentioned, in the treatment of endometritis this active principle can be used in combination with amoxicillin and gentamicin.
