DECA-DURABOLIN ® is a drug based on Nandrolone decaonate
THERAPEUTIC GROUP: Androgens
Indications DECA-DURABOLIN ® - Nandrolone
DECA-DURABOLIN ® is used in the treatment of symptoms in men with androgynous deficiency, or as an adjuvant therapy in some forms of osteoporosis.
Mechanism of action DECA-DURABOLIN ® - Nandrolone
Nortestosterone, more commonly known as Nandrolone, is a derivative of testosterone, from which it differs in the presence of a methyl group in position 19, which gives it a long duration of action (estimated around 130 hours) and above all a reduced androgenizing power, responsible for numerous side effects of hormone replacement therapy based on androgens such as acne, hirsutism, alopecia and prostatic hypertrophy.
However this metabolite, normally present in the metabolic pathways of steroid hormones, maintains a modest estrogenic effect, linked to the conversion by aromatase, and a progestin-like activity, able to inhibit the hypothalamic-pituitary axis by feedback reducing the secretion of gondatropine. , therefore also the endogenous one of testosterone.
At the same time, the nandrolone contained in DECA-DURABOLIN ® maintains the same anabolic power as testosterone:
- By improving hematopoiesis and ensuring a significant increase in serum hemoglobin and the number of erythrocytes;
- By positivising the nitrogen balance, with an increase in the levels of protein synthesis, responsible for the inductive effect on the muscle mass;
- By modulating bone turnover in favor of neodeposition processes, increasing intestinal calcium absorption and increasing bioavailability, thus protecting the patient from the risk of osteoporosis;
- Improving sexual function, also significantly affecting sexual libido;
- Contributing to the development, maturation and maintenance of male secondary sexual characteristics.
Studies carried out and clinical efficacy
1. NANDROLONE IN HIV PATIENTS
AIDS. 1996 Jun; 10: 745-52.
Safety and efficacy of nandrolone decanoate for treatment of wasting in patients with HIV infection.
Gold J, High HA, Li Y, Michelmore H, Bodsworth NJ, Finlayson R, Furner VL, Allen BJ, Oliver CJ.
Clinical trial that demonstrates how the administration of nandrolone can benefit the health of the patient with HIV, counteracting cachexia and improving body weight, lean mass and quality of life of these patients.
2. NANDROLONE AND LACK OF HYPERTROPHY: Experimental study
Arq Bras Endocrinol Metabol. 2006 Jun; 50: 532-40.
[Nandrolone administration does not promote hypertrophy of soleus muscle in rats].
Cunha TS, Tanno AP, Marcondes FK, Perez SE, Selistre-Araújo HS.
Experimental study, which dispels some of the promises for which nandrolone would be used in sports. More precisely, the administration of this hormone in mice did not cause hypertrophy of the soleus muscle, even when combined with resistance exercise.
3. NANDROLONE IN EPO "REFRACTORY ANEMIA"
Compr Ther. 2009 Fall-Winter; 35 (3-4): 199-203.
Nandrolone decanoate for the treatment of erythropoietin refractory anemia: a case series.
Chawla B, Iqbal FM, Chawla MS.
Work showing a new therapeutic approach to erythropoietin-refractory anemia. In these rare cases the administration of nandrolone seems not only to improve the number of erythrocytes but also that of white blood cells and platelets.
Method of use and dosage
DECA-DURABOLIN ®
Oily solution for intramuscular injection contained in ampoules of 25 or 50 mg of nandrolone decanoate:
in light of the chemical-structural and pharmacokinetic characteristics of nandrolone, the intake of this hormone should take place on average every 3 weeks.
The dosage to use, usually between 25 - 50 mg per injection, should instead be defined by your doctor, after a "careful evaluation of the patient's clinical condition.
Warnings DECA-DURABOLIN ® - Nandrolone
The intake of DECA-DURABOLIN ® must necessarily be preceded by a careful medical examination useful to evaluate the prescribing appropriateness and the possible presence of morbid conditions, the clinical course of which could worsen following the intake of nandrolone.
In this regard, patients suffering from hypertension, heart disease, family history or history of neoplastic diseases, liver and kidney diseases and epilepsy should carefully evaluate with their doctor the cost / benefit ratio that would derive from taking nandrolone, possibly considering the need to resort periodic checks useful for monitoring the patient's psychophysical state of health.
Especially in the initial phase of administration, the intake of DECA-DURABOLIN ® should be supervised by health personnel, given the possible complications associated with poorly made intramuscular injections with oily material.
At the onset of the first clinical biological disorders or the first signs of sexual or nervous hyperstimulation, the physician should discontinue treatment.
The use in prepubertal age should instead take place with particular attention, given the possible deleterious effects on bone growth and on the too rapid development of the male genital organs.
By decree of the Ministry of Health of 11 June 2010, published in the Official Gazette n. 145 of 24 June 2010, the substance
NANDROLONE (common name)
17-HYDROXY-4-ESTREN-3-ONE (chemical name)
19-NORTESTOSTERONE (other denomination)
has been inserted, with affection since 9 July 2010, in table I and in table II, sect. To drugs and psychotropic substances. Among the reasons we read that this substance was included among drugs at the request of the "Commission for the supervision and control of doping and for the protection of health in sports activities" and on the positive opinion of the competent advisory bodies of the Ministry of Health. For this substance, in fact, concrete dangers of inducing severe psychic dependence have been ascertained.
PREGNANCY AND BREASTFEEDING
Nandrolone is able to cross the hematoplacental barrier, thus reaching the fetal circulation and thus inducing virilization of the fetus, potentially responsible for reproductive problems.
In light of these data, the use of DECA-DURABOLIN ® is contraindicated both during pregnancy and in the subsequent lactation period.
Interactions
Although at the moment there are still few studies able to characterize the possible drug interactions of nandrolone, it is useful to remember, as it is a direct derivative of testosterone, its intake if carried out in conjunction with anticoagulants, hypoglycemic agents or cortisone could increase the risk respectively. of haemorrhages, hypoglycemia and hypertension.
Contraindications DECA-DURABOLIN ® - Nandrolone
The intake of nandrolone is contraindicated in case of hypersensitivity to the active substance or to one of its excipients, breast cancer, estrogen-dependent neoplasms, prostatic cancer and hypertrophy, history of hepatocarcinoma, hypercalcemia, nephrotic syndrome, pregnancy and lactation.
Undesirable Effects - Side Effects
Although nandrolone can significantly reduce the appearance of side effects typical of androgen therapy such as acne, water retention, hypertension, myalgia, the intake of DECA-DURABOLIN ® especially when carried out outside the medical indications, could be responsible for side effects as an inhibition of spermatogenesis in man, reduced tolerance to carbohydrates and an increase in blood concentrations of triglycerides.
The use of DECA-DURABOLIN ® for anabolic purposes in women could be associated with virilization resulting in hirsutism, increased libido, acne, and hoarseness.
Note
DECA-DURABOLIN ® can only be sold under medical prescription.
DECA-DURABOLIN ® is an anabolic agent, therefore its use, outside of medical prescriptions on a pathological basis, is prohibited in and out of competition.
By decree of the Ministry of Health of 11 June 2010, published in the Official Gazette n. 145 of 24 June 2010, the substance
NANDROLONE (common name)
17-HYDROXY-4-ESTREN-3-ONE (chemical name)
19-NORTESTOSTERONE (other denomination)
has been inserted, with affection since 9 July 2010, in table I and in table II, sect. To drugs and psychotropic substances. Among the reasons we read that this substance was included among drugs at the request of the "Commission for the supervision and control of doping and for the protection of health in sports activities" and on the positive opinion of the competent advisory bodies of the Ministry of Health. For this substance, in fact, concrete dangers of inducing severe psychic dependence have been ascertained.
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