CITROSODINA ® Sodium bicarbonate

CITROSODINA ® is a sodium bicarbonate based drug.

THERAPEUTIC GROUP: Antacids.

Indications CITROSODINA ® Sodium bicarbonate

CITROSODINA ® is indicated in the treatment of heartburn and painful symptoms associated with the condition of gastric hyperacidity.

Mechanism of action CITROSODINA ® Sodium bicarbonate

The therapeutic action of CITROSODINA ® is due to the presence of sodium bicarbonate, a salt with basic digestion, effective in buffering gastric acidity.
Compared to other antacids, sodium bicarbonate is able to guarantee an immediate antacid effect, thanks to its ability to bind hydrogen ions in the gastric environment, releasing water, sodium and carbon dioxide, but it is not very suitable for the "chronic" and prolonged treatment of " stomach acid.
This important limitation is due to the formation of products, such as sodium chloride, which following a prolonged intake over time and its systemic absorption, can cause an increased reabsorption of water, with a consequent increase in plasma volume (among the possible risk factors for hypertension), and CO2, which by dilating the gastric wall, can contribute to the onset of a reactive acidosis, through the induction of gastric secretion.
The high buffering power, the rapidity of action and the potential associated side effects make CITROSODINA ® a useful remedy for acute and isolated episodes of stomach acid.

Studies carried out and clinical efficacy

1. SODIUM BICARBONATE AND KIDNEY PATHOLOGY

J Am Soc Nephrol. 2009 Sep; 20: 2075-84. Epub 2009 Jul 16.

Bicarbonate supplementation slows progression of CKD and improves nutritional status.

de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM.

Oral supplementation of sodium bicarbonate has been shown to be useful in reducing the progression of renal disease by preserving the nutritional status of patients, recording a maintenance of creatinine clearance, arm muscle mass, serum albumin and other important markers clinical.

2. SODIUM BICARBONATE AND DIABETES

Endocrine. 2010 Oct; 38: 221-6. Epub 2010 Jul 17.

No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults.

Harris SS, Dawson-Hughes B.

One of the most common complications affecting diabetic patients is acidosis, which among the many side effects also seems to further reduce the sensitivity of the tissues to insulin. This study tested the ability of sodium bicarbonate taken orally to improve glucose metabolism, without however recording any positive effects, monitored through HOMA TEST.

3. SODIUM BICARBONATE AND PHYSICAL ACTIVITY

Eur J Appl Physiol. 2011 Jan 1. [Epub ahead of print]

Effects of bicarbonate ingestion and high intensity exercise on lactate and H (+) - ion distribution in different blood compartments.

Zinner C, Wahl P, Achtzehn S, Sperlich B, Mester J.

Although the scientific literature is rich in studies regarding the efficacy of sodium bicarbonate in improving athletic performance, the question is still an open debate. Several studies support its efficacy, while recent evidence suggests that the buffering effect is mainly expressed in the gastric level, and how oral ingestion of this salt is unable to improve tissue acidosis.

Method of use and dosage

CITROSODINA ® effervescent granules of 16.41 gr of sodium bicarbonate and 13.95 gr of citric acid monohydrate per 100gr, sachets of 1.64 gr of sodium bicarbonate and 1,395 of citric acid monohydrate, tablets of 250 mg of sodium citrate:
for the treatment of sporadic episodes of gastric acidity it is recommended to take 2 coffee spoons of effervescent granules, 1 sachet or 4 tablets 3-4 times a day. The intake of this drug is indicated in the treatment for short periods.

Warnings CITROSODINA ® Sodium bicarbonate

Although CITROSODINA ® is devoid of particular side effects, it should be remembered that the presence of sodium salts may not be indicated in patients suffering from severe renal insufficiency, marked hypertension, or individuals on a low-sodium diet. In these cases the intake of CITROSODINA ® should be closely monitored by your doctor.
The presence of sucrose in the drug could be responsible for gastrointestinal side effects in patients with glucose / galactose intolerance, fructose or with isomaltase enzyme deficiency.
CITROSODINA ® does not alter the normal ability to drive vehicles or use machines.

PREGNANCY AND BREASTFEEDING

CITROSODINA ® has not been shown to be toxic at therapeutic doses, when taken during pregnancy, neither for the mother nor for the unborn child. Nevertheless it would be advisable to consult your doctor before taking this drug during pregnancy or while breastfeeding.

Interactions

Pharmacokinetic studies show how antacids can inhibit the absorption of many other active ingredients, significantly reducing both their bioavailability and their therapeutic efficacy.
In this regard, it is recommended not to take any type of drug within the first two hours of taking CITROSODINA ®

Contraindications CITROSODINA ® Sodium bicarbonate

CITROSODINA ® is contraindicated in case of hypersensitivity to one of its components, severe hypertension, severe heart and kidney failure.

Undesirable Effects - Side Effects

CITROSODINA ® is very well tolerated, so much so that the literature does not show any type of side effect if taken at the doses and in the manner prescribed and indicated by the doctor.
An increase in sodium absorption with a consequent increase in plasma volume, could occur in hypertensive patients, with worsening of the disease, or following prolonged intake of this medicine.

Note

CITROSODINA ® is a free sale drug.

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