BENEXOL B12 ® is a drug based on B vitamins and more precisely thiamine (B1), pyridoxine (B6) and cyanocobalamine (B12)
THERAPEUTIC GROUP: Vitamin B1 in association with Vitamin B6 and Vitamin B12
Indications BENEXOL B12 ® - Thiamine + Pyridisoxine + Cyanocobalamine
BENEXOL B12 ® is indicated in the treatment of deficient states of B vitamins, or as adjuvant therapy in the course of non-deficient neuritis, hyperemesis gravidarum and radiotherapy.
Mechanism of action BENEXOL B12 ® - Thiamine + Pyridisoxine + Cyanocobalamine
BENEXOL B12 ® is a drug based on vitamins of group B and more precisely of vitamin B1, vitamin B6 and vitamin B12, indicated in the treatment of deficient states of these elements.
From the physiological and biochemical point of view, the aforesaid vitamins are part of the control of numerous enzymatic reactions as necessary cofactors for their advancement.
Vitamin B1, also known as thiamine, is in fact essential in assisting oxidative decarboxylation and tranketolation reactions useful for the production of energy and the synthesis of macromolecules such as nucleic acids.
Vitamin B6, also called pyridoxine, is instead useful in supporting the enzymatic activity of decarboxylases and transaminases, useful both in ergogenic reactions and in those of biosynthesis of neurotransmitters such as GABA, dopamine, serotonin and noradrenaline.
Finally, vitamin B12, in its most effectively absorbable form such as Cyanocobalamine, through the purchase and transfer of methyl groups, is able to support the synthesis of Thymine, a useful base for cell replication processes, detoxification from homocysteine and transformation of a potentially neurotoxic substance such as methylmalonic acid into succinyl CoA.
In the light of the biological functions of the single vitamins and of the predominantly neurotrophic and neuroprotective action, it is evident that the greatest use of BENEXOL B12 ® is intended for the treatment of deficient and non-deficient neuritis.
Studies carried out and clinical efficacy
1. GROUP B VITAMINS AND CHRONIC WORKING STRESS
Hum Psychopharmacol. 2011 Oct; 26: 470-6.
The effect of 90 day administration of a high dose vitamin B-complex on work stress.
Stough C, Scholey A, Lloyd J, Spong J, Myers S, Downey LA.
High-dose supplementation of B vitamins for 90 days in employees subjected to heavy workloads, resulted in an improvement in mood and a reduction in psychological tensions associated with chronic work stress.
2. CHEMICAL-PHYSICAL STABILITY OF GROUP B VITAMINS
J Pharm Biomed Anal. 2011 Jul 15, 55: 1197-200. Epub 2011 Mar 29.
Stability of the vitamin B complex in the multivitamin and multimineral supplement tablets after space flight.
Chuong MC, Prasad D, Leduc B, Du B, Putcha L.
Very interesting study that demonstrates the high chemical-physical stability of the B complex vitamins, even in extreme conditions such as space flight. These results therefore suggest the effectiveness of these supplements in aerospace dietetics.
3. THE POTENTIAL ANALGESIC EFFECTS OF BENEXOL
Acta Vitaminol Enzymol. 1985; 7 (1-2): 9-18.
Analgesic activity of Benexol-B12 in the painful vertebral syndrome.
Destito D, Canon N, Tentori-Montalto T.
Study dated 1985, which investigates the potential analgesic effects of BENEXOL B12 ® in patients with painful vertebral syndrome. The results, not clarifying, should be reassessed from a statistical point of view to obtain more precise information.
Method of use and dosage
BENEXOL B12 ®
Gastro-resistant tablets of 250 mg of thiamine hydrochloride, 250 mg of pyridoxine hydrochloride and 500 mcg of cyanocobalamine;
solvent and powder of 38 mg of cocarboxylase, 200 mg of pyridoxine hydrochloride and 1000 mcg of hydroxocobalamine acetate;
solvent and powder of 38 mg of cocarboxylase, 300 mg of pyridoxine hydrochloride and 5000 mcg of hydroxocobalamine acetate;
the treatment of deficient states of group B vitamins and their use as adjuvant therapy in the treatment of hyperemesis gravidarum, non-deficient neuritis and radiotherapy requires the assumption of one tablet a day for periods equal to or greater than one week.
In the case of particularly severe clinical conditions, the doctor may decide to increase the dosage used or to vary the pharmaceutical form, preferring BENEXOL B12 ® in powder and solvent for solutions for intramuscular injection.
Warnings BENEXOL B12 ® - Thiamine + Pyridisoxine + Cyanocobalamine
The high vitamin dosages present in BENEXOL B12 ® suggest the use of this drug for limited periods of time, necessary to restore normal equilibrium conditions, and preferably under medical supervision.
The use of BENEXOL B12 ® in solution for intramuscular injection could be more likely associated with the onset of severe allergic reactions, therefore it is advisable to resort, where possible, to taking the medicine in gastro-resistant tablets.
It is also useful to remember that pyridoxine in such high dosages could in some cases antagonize the therapeutic effects of levodopa.
PREGNANCY AND BREASTFEEDING
The high vitamin dosages, much higher than the normal daily needs, extend the aforementioned contraindications also to pregnancy and the subsequent period of breastfeeding.
Interactions
Taking BENEXOL B12 ® orally, when taken at the same time as taking other active ingredients such as metformin, oral contraceptives, antihistamines and proton pump inhibitors, could expose the vitamins it contains to significant reductions in intestinal absorption.
The simultaneous intake of anti-tuberculosis drugs such as isionazide, L-dopa or penicillamine, could facilitate the formation of molecular complexes containing vitamin B6, thus causing a functional deficit of this vitamin while drugs such as furosemide and anticonvulsants could alter the normal pharmacokinetic properties of thiamine.
The B vitamins could also determine significant changes in blood chemistry tests.
Contraindications BENEXOL B12 ® - Thiamine + Pyridisoxine + Cyanocobalamine
BENEXOL B12 ® is contraindicated in patients with hepatic and renal insufficiency, during pregnancy and lactation and in case of hypersensitivity to the active substance or to one of its excipients.
Undesirable Effects - Side Effects
The data derived from clinical experience show how the assumption of BENEXOL B12 ® can cause the onset of diarrhea, nausea and abdominal pain.
Rarely, allergic reactions characterized by dyspnoea, skin rashes, erythema, urticaria, and in the most severe cases anaphylactic shock have also been observed.
Note
BENEXOL B12 ® in gastro-resistant tablets is a SOP drug, therefore it can be sold in pharmacies without a prescription.
BENEXOL B12 ® solvent and powder for solution for injection, on the other hand, is subject to a medical prescription.
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